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http://dx.doi.org/10.5657/KFAS.2019.0081

Effect of a Sargassum serratifolium Extract on Neuroinflammation Induced by Lipopolysaccharides in Mice  

Choi, Min-Woo (Department of Food Science and Nutrition, Pukyong National University)
Kim, Hyeung-Rak (Department of Food Science and Nutrition, Pukyong National University)
Lee, Hyoung-Gon (Department of Biology, University of Texas at San Antonio)
Kim, Jae-Il (Department of Food Science and Nutrition, Pukyong National University)
Publication Information
Korean Journal of Fisheries and Aquatic Sciences / v.52, no.1, 2019 , pp. 81-86 More about this Journal
Abstract
The common hallmark of several neurodegenerative disorders, including Alzheimer's disease (AD), is the presence of chronic neuroinflammation, which contributes to the loss of neuronal structure and function. This study investigated the effects of an ethanolic extract of Sargassum serratifolium (SSE) in a lipopolysaccharides (LPS)-induced murine neuroinflammation model. Mice were administered SSE (100 mg/kg body weight) or vehicle for 5 days by oral gavage, and then treated with LPS or saline by intraperitoneal injection. Thereafter, the brain tissues were collected, and the expression of pro-inflammatory cytokines was analyzed by quantitative real-time RT-PCR. There was a marked increase in the spleen weight index in the LPS-treated groups, which indicated the induction of acute systemic inflammation. Based on significant increases in the levels of IL-1 and IL-6 expression, the induction of neuroinflammation was also evident in the cortex and hippocampus of the LPS-treated groups. The overall expression of IL-1 and IL-6 was decreased slightly by SSE administration, compared with the LPS group, and a marked change in IL-1 was observed in the cortex of the SSE-treated (SSE/LPS) group. These results suggest that SSE has potential as an anti-neuroinflammatory nutraceutical.
Keywords
Neurodegenerative disorders; Neuroinflammation; Brown seaweeds; Sargassum serratifolium; Lipopolysaccharides;
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