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http://dx.doi.org/10.4163/jnh.2015.48.4.299

Effects of the C3G/D3G anthocyanins-rich black soybean testa extracts on improvement of lipid profiles in STZ-induced diabetic rats  

Park, So Young (Research Institute of Obesity Science, Sungshin Women's University)
Pak, Sujeong (Research Institute of Obesity Science, Sungshin Women's University)
Kang, Song Joo (Department of Food and Nutrition, Sungshin Women's University)
Kim, Na Young (Department of Food and Nutrition, Sungshin Women's University)
Kim, Da Saem (Department of Food and Nutrition, Sungshin Women's University)
Kim, Min Jin (Department of Food and Nutrition, Sungshin Women's University)
Kim, Seon Ah (Department of Food and Nutrition, Sungshin Women's University)
Kim, Ji Young (Department of Food and Nutrition, Sungshin Women's University)
Park, So Yeon (Department of Food and Nutrition, Sungshin Women's University)
Park, So Hyun (Department of Food and Nutrition, Sungshin Women's University)
Youn, Cho Rong (Department of Food and Nutrition, Sungshin Women's University)
Lee, Bo Ram (Department of Food and Nutrition, Sungshin Women's University)
Lee, Hyo Eun (Department of Food and Nutrition, Sungshin Women's University)
Choi, So Young (Department of Food and Nutrition, Sungshin Women's University)
Choi, Hee Won (Department of Food and Nutrition, Sungshin Women's University)
Heo, Jin Yeo (Department of Food and Nutrition, Sungshin Women's University)
Hwang, A Yeong (Department of Food and Nutrition, Sungshin Women's University)
Lee, Myoung Sook (Research Institute of Obesity Science, Sungshin Women's University)
Publication Information
Journal of Nutrition and Health / v.48, no.4, 2015 , pp. 299-309 More about this Journal
Abstract
Purpose: The purpose of this study was to examine the effect of black soybean (CJ-3) testa extracts on lipid profiles in streptozotocin (STZ)-induced diabetic rats. Methods: One control group and four STZ-induced diabetic groups with different doses of black soybean (CJ-3) testa extracts treatment [0 mg/kg (diabetic control, EX), 250 mg/kg (EX-250), 500 mg/kg (EX-500), 1,000 mg/kg (EX-1000)] were orally administered for 4 weeks. Results: All CJ-3 treatment groups had remarkably lower serum triglyceride (TG) levels than that of EX group (p < 0.05) whereas hepatic TG contents did not show any differences. Results from serum total cholesterol (TC) concentrations of EX-250 and EX-1000 groups were decreased compared to EX group (p < 0.05). Furthermore, protein levels of 3-hydroxy-3-methyl-glutaryl-Coenzyme A (HMG-CoA) reductase from the liver decreased in all treatment groups (p < 0.05). However, significant differences were not observed in serum glucose and insulin, and glucose transporter 4 (GLUT-4) protein expression in skeletal muscle tissue. Conclusion: These results suggest that black soybean testa extracts could be useful for improvement of hyperlipidemia and hypercholesteremia in diabetes.
Keywords
anthocyanin; black soybean testa; lipid profiles; streptozotocin; diabetes;
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Times Cited By KSCI : 11  (Citation Analysis)
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