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http://dx.doi.org/10.4163/kjn.2013.46.2.119

Effects of medicinal herb water extracts on expression of hepatic glucokinase, pyruvate dehydrogenase and acetyl-CoA carboxylase mRNA  

Kim, Hyun Sook (Well-being Bioproducts RIC Center, Kangwon National University)
Kim, Tae Woo (Well-being Bioproducts RIC Center, Kangwon National University)
Kim, Dae Jung (Well-being Bioproducts RIC Center, Kangwon National University)
Lee, Jae Sung (Department of Bio-Health Technology, Kangwon National University)
Choe, Myeon (Well-being Bioproducts RIC Center, Kangwon National University)
Publication Information
Journal of Nutrition and Health / v.46, no.2, 2013 , pp. 119-125 More about this Journal
Abstract
We studied the anti-diabetic effects of medicinal herb water extracts on expression of hepatic glucokinase (GCK), pyruvate dehydrogenase (PDH), and acetyl-CoA carboxylase (ACC) mRNA. The medicinal herbs used for experiments were Cornus officinalis (CO), Paeonia suffruticosa Andrews (PSA), Discorea japonica Thunb. (DJ), Rehmannia glutinosa (RG), Lycium chinense (LC), and Pyrus pyrifolia (PP). For GCK mRNA expression, CO, RG, and LC water extracts exhibited a more effective activity than other extracts. Cells treated with RG and LC water extracts showed an increase in expression of PDH mRNA to 191% and 124%, respectively, compared to control. Expression of ACC mRNA was significantly higher in LC water extract. These data indicate that CO, RG, and LC water extracts stimulates expression of hepatic GCK, PDH, and ACC mRNA.
Keywords
anti-diabetic; glucokinase; pyruvate dehydrogenase; acetyl-CoA carboxylase; medicinal herb;
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Times Cited By KSCI : 6  (Citation Analysis)
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