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http://dx.doi.org/10.4163/kjn.2011.44.1.82

Iodine Intake and Tolerable Upper Intake Level of Iodine for Koreans  

Lee, Hyun-Sook (Department of Food & Nutrition, Kookmin University)
Min, Hye-Sun (Department of Food & Nutrition, Hannam University)
Publication Information
Journal of Nutrition and Health / v.44, no.1, 2011 , pp. 82-91 More about this Journal
Abstract
The present study reviewed the effects of excess iodine intake on thyroid function and the incidence of thyroid disease and discussed the scientific basis for establishing a tolerable upper intake level (UL) of iodine for Koreans. ULs are defined as "the highest level of daily nutrient intake that is likely to pose no risk of adverse effects to almost all individuals in the general population." Koreans consume excess iodine from seaweed, and iodine intake is strongly influenced by seaweed consumption. However, no dose-response data derived from subjects consuming excess iodine frequently but not continuously during a lifetime are available. Therefore, the Korean DRI committee set the iodine UL to reduce the risk of adverse health effects by excess iodine intake for Koreans with distinctive seaweed-eating habits.
Keywords
iodine excess; thyroid dysfunction; urinary iodine excretion; UL; Koreans;
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1 Franceschi S. Iodine intake and thyroid carcinoma--a potential risk factor. Exp Clin Endocrinol Diabetes 1998; 106 (Suppl3): S38-S44
2 Teng W, Shan Z, Teng X, Guan H, Li Y, Teng D, Jin Y, Yu X, Fan C, Chong W, Yang F, Dai H, Yu Y, Li J, Chen Y, Zhao D, Shi X, Hu F, Mao J, Gu X, Yang R, Tong Y, Wang W, Gao T, Le C. Effect of iodine intake on thyroid diseases in China. N Engl Med 2006; 354: 2783-2793
3 Scientific Committee on Food. Opinion of the scientific Committee on Food on the Tolerable Upper Level of Iodine. European Commission, SCF/CS/NUT/UPPLEV/21 Final Brussels; 2002
4 Ministry of Health, Labour and Welfare. Dietary Reference Intakes for Japanese. Japan; 2010
5 Wolff J. Iodide goiter and the pharmacologic effects of excess iodide. Am J Med 1969; 47: 101-124
6 Chung HR, Shin CH, Yang SW, Choi CW, Kim BI. Subclinical hypothyroidism in Korean preterm infants associated with high levels of iodine in breast milk. J Clin Endocrinol Metab 2009; 94(11): 4444-4447
7 Zimmermann MB, Aeberli I, Torresani T, Burgi H. Increasing the iodine concentration in the Swiss iodized salt program markedly improved iodine status in pregnant women and children: a 5-y prospective national study. Am J Clin Nutr 2005; 82: 388-392
8 Zimmermann MB, Ito Y, Hess SY, Fujieda K, Molinari L. High thyroid volume in children with excess dietary iodine intakes. Am J Clin Nutr 2005; 81: 840-844
9 Weaver DK, Batsakis JG, Nishiyama RH. Relationship of iodine to "lymphocytic goiters". Arch Surg 1969; 98(2): 183-186
10 Expert Group on Vitamins and Minerals. Safe upper levels for vitamins and minerals, Food Standards Agency, United Kingdom; 2003
11 Braverman LE. Effects of iodine on thyroid function in man. Trans Am Clin Climatol Assoc 1991; 102: 143-151
12 Vidor GI, Stewart JC, Wall JR, Wangel A, Hetzel BS. Pathogenesis of iodine-induced thyrotoxicosis: studies in northern Tasmania. J Clin Endocrinol Metab 1973; 37(6): 901-909
13 Parle JV, Franklyn JA, Cross KW, Jones SC, Sheppard MC. Prevalence and follow-up of abnormal thyrotrophin (TSH) concentrations in the elderly in the United Kingdom. Clin Endocrinol (Oxf) 1991; 34(1): 77-83
14 Pearce EN, Gerber AR, Gootnick DB, Khan LK, Li R, Pino S, Braverman LE. Effects of chronic iodine excess in a cohort of long-term American workers in West Africa. J Clin Endocrinol Metab 2002; 87(12): 5499-5502
15 Cho YW, Kim YS, Baick SH, Oh DY, Kim WJ, Chang NS, Kang MW, Kim KS. Analysis of daily intake and urinary excretion of iodine in normal control and patient with thyroid disease. J Korean Soc Endocrinol 1994; 9(4): 307-317
16 Park HY, Lee SI, Kim WB, Kim SY, Cho BY, Lee HK, Koh CS. A study on the urinary iodine excretion in normal subjects and patients with thyroid disease. J Korean Soc Endocrinol 1995; 10(4): 386-394
17 Food and Nutrition Board, Institute of Medicine. Iodine. In: Institute of Medicine, ed. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, anadium, and zinc. Washington D.C.: National Academies Press; 2001. p.58-289
18 Choue R, Yim J, Cho y, Lee W. The effects of dietary iodine intake on the postpartum thyrioditis (PPT) manifestation. Korean J Nutr 1997; 30(10): 1195-1202
19 Bagchi N, Brown TR, Parish RF. Thyroid dysfunction in adults over age 55 years. A study in an urban US community. Arch Intern Med 1990; 150(4): 785-787
20 Ozbakir O, Dogukan A, Kelestimur F. The prevalence of thyroid dysfunction among elderly subjects in an endemic goiter area of Central Anatolia. Endocr J 1995; 42(5): 713-716
21 Szabolcs I, Kovacs Z, Gonczi J, Kakosy T, Goth M, Dohan O, Kovacs L, Szilagyi G. Prevalence of thyroid dysfunction in different geriatric subpopulations from a moderately iodine-deficient Hungarian region. Comparative clinical and hormonal screening. Eur J Endocrinol 1995; 133(3): 294-299
22 Pearce EN, Gerber AR, Gootnick DB, Khan LK, Li R, Pino S, Braverman LE. Effects of chronic iodine excess in a cohort of long-term American workers in West Africa. J Clin Endocrinol Metab 2002; 87(12): 5499-5502
23 WHO/UNICEF/ICCIDD. Assessment of the iodine deficiency disorders and monitoring their elimination. Geneva: WHO; 2001
24 Fisher DA, Oddie TH. Thyroidal radioiodine clearance and thryoid iodine accumulation: contrast between random daily variation and population data. J Clin Endocrinol Metab 1969; 29: 111-115
25 The Korean Nutrition Society. Dietary Reference Intakes for Koreans, 1st revision, Seoul; 2010
26 Kim WB, Moon BS, Lim CH, Park KS, Kim SY, Cho BY, Lee HK, Lee JH, Jeon HW, Jin HJ. The incidence of postpartum thyroiditis and effect of high iodine intake on it in Korean women. J Korean Soc Endocrinol 1998; 13(3); 339-350
27 Okamura K, Ueda K, Sone H, Ikenoue H, Hasuo Y, Sato K, Yoshinari M, Fujishima M. A sensitive thyroid stimulating hormone assay for screening of thyroid functional disorder in elderly Japanese. J Am Geriatr Soc 1989; 37(4): 317-322
28 Eggertsen R, Petersen K, Lundberg PA, Nystrom E, Lindstedt G. Screening for thyroid disease in a primary care unit with a thyroid stimulating hormone assay with a low detection limit. BMJ 1988; 297(6663): 1586-1592
29 Fisher DA, Oddie TH. Thyroid iodine content and turnover in euthyroid subjects: validity of estimation of thyroid iodine accumulation from short.term clearance studies. J Clin Endocrinol Metab 1969; 29: 721-727
30 dos Remedios LV, Weber PM, Feldman R, Schurr DA, Tsoi TG. Detecting unsuspected thyroid dysfunction by the free thyroxine index. Arch Intern Med 1980; 140(8): 1045-1049
31 Utiger RD. The diverse effects of iodide on thyroid function. N Engl J Med 1972; 287(11): 562-563
32 Stanbury JB, Ermans AE, Bourdoux P, Todd C, Oken E, Tonglet R, Vidor G, Braverman LE, Medeiros-Neto G. Iodine-induced hyperthyroidism: Occurrence and epidemiology. Thyroid 1998; 8: 83-100
33 Laurberg P, Bülow Pedersen I, Knudsen N, Ovesen L, Andersen S. Environmental iodine intake affects the type of nonmalignant thyroid disease. Thyroid 2001; 11(5): 457-469
34 Zimmermann MB, Hess SY, Molinari L, De Benoist B, Delange F, Braverman LE, Fujieda K, Ito Y, Jooste PL, Moosa K, Pearce EN, Pretell EA, Shishiba Y. New reference values for thyroid volume by ultrasound in iodine sufficient schoolchildren: a World Health Organization/Nutrition for Health and Development Iodine Deficiency Study Group Report. Am J Clin Nutr 2004; 79(2): 231-237
35 Nishiyama S, Mikeda T, Okada T, Nakamura K, Kotani T, Hishinuma A. Transient hypothyroidism or persistenthyperthyrotropinemia in neonates born to mothers with excessive iodine intake. Thyroid 2004; 14: 1077-1083
36 Chung JH, Kim BJ, choi YH, Shin MH, Kim SH, Min YK, Lee MS, Lee MK, Kim KW. Prevalence of thyrotoxicosis and hypothyroidism in the subjects for health check-up. J Korean Soc Endocrinol 1999; 14: 301-313
37 Okamura K, Nakashima T, Ueda K, Inoue K, Omae T, Fujishima M. Thyroid disorders in the general population of Hisayama Japan, with special reference to prevalence and sex differences. Int J Epidemiol 1987; 16(4): 545-549
38 Pretell EA, Delange F, Hostalek U, Corigliano S, Barreda L, Higa AM, Altschuler N, Barragán D, Cevallos JL, Gonzales O, Jara JA, Medeiros-Neto G, Montes JA, Muzzo S, Pacheco VM, Cordero L. Iodine nutrition improves in Latin America. Thyroid 2004; 14(8): 590-599
39 Katamine S, Mamiya Y, Sekimoto K, Hoshino N, Totsuka K, Naruse U, Watabe A, Sugiyama R, Suzuki M. Iodine content of various meals currentlyconsumed by urban Japanese. J Nutr Sci Vitaminol (Tokyo) 1986; 32: 487-495
40 Korean Food & Drug Administration. Report on the intake of sugar, sodium, and the rest of Korean; 2007. 11. 22
41 Laurberg P, Cerqueira C, Ovesen L, Rasmussen LB, Perrild H, Andersen S, Pedersen IB, CarleA. Iodine intake as a determinant of thyroid disorders in populations. Best Pract Res Clin Endocrinol Metab 2010; 24(1): 13-27
42 Pennington JA. A review of iodine toxicity reports. J Am Diet Assoc 1990; 90: 1571-1581
43 Dai G, Levy O, Carraco N. Cloning and characterization of thyroid iodide transporter. Nature 1996; 379: 458-460
44 Wolff J, Chaikoff IL, Goldberg RC, Meier JR. The temporary nature of the inhibitory action of excess iodine on organic iodine synthesis in the normal thyroid. Endocrinology 1949; 45 (5): 504-513
45 Vanderveen JE. Gap analysis guidelines for assessing acute, chronic, and lifetime exposures to high levels of various nutrients. J Nutr 2006; 136(2): 514S-519S
46 Kim KR. The iodine and thyroid disease. J Korean Soc Endocrinol 1994; 9(4): 284-289
47 Kim HM, Lee HC, Park KS, Joo HY, Kim KR, Hong CS, Huh KB, Lee SY, Ryu KJ. A study on the urinary iodide excretion in normal subjects and patients with thyroid disease. Korean J Intern Med 1985; 29(5): 625-631
48 Markou K, Georgopoulos N, Kyriazopoulou V, Vagenakis AG. Iodine-Induced hypothyroidism. Thyroid 2001; 11(5): 501-510
49 STANLEY MM. The direct estimation of the rate of thyroid hormone formation in man; the effect of the iodide ion on thyroid iodine utilization. J Clin Endocrinol Metab 1949; 9(10):941-954
50 Kim JY, Kim KR. Dietary iodine intake and urinary iodine excretion in patients with thyroid disease. Yonsei Med J 2000; 41: 22-28
51 Cook JD. Adaptation in iron metabolism. Am J Clin Nutr 1990; 51(2): 301-308
52 Suzuki H, Higuchi T, Sawa K, Ohtaki S, Horiuchi Y. "Endemic coast goiter" in Hokkaido, Japan. Acta Endocrinol 1965; 50: 161-176
53 Braverman LE, Ingbar SH. Changes in thyroidal function during adaptation to large doses of iodide. J Clin Invest 1963; 42: 1216-1231
54 Eng PH, Cardona GR, Fang SL, Previti M, Alex S, Carrasco N, Chin WW, Braverman LE. Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein. Endocrinology 1999; 140(8): 3404-3410
55 Burgi H. Iodine excess. Best Pract Res Clin Endocrinol Metab 2010; 24(1): 107-115
56 Bothwell TH, MacPhail AP. Hereditary hemochromatosis: etiologic, pathologic, and clinical aspects. Semin Hematol 1998; 35(1): 55-71
57 Vought RL, London WT, Lutwak L, Dublin TD. Reliability of estimates of serum inorganic iodine and daily fecal and urinary iodine excretion from single casual specimens. J Clin Endocrinol Metab 1963; 23: 1218-1228
58 Wolff J, Chaikoff IL. Plasma inorganic iodide as a homeostatic regulator of thyroid function. J Biol Chem 1948; 174(2): 555-564
59 Konno N, Yuri K, Taguchi H, Miura K, Taguchi S, Hagiwara K, Murakami S. Screening for thyroid diseases in an iodine sufficient area with sensitive thyrotrophin assays, and serum thyroid autoantibody and urinary iodide determinations. Clin Endocrinol (Oxf) 1993; 38(3): 273-281
60 Jolin T, Escobardelrey F. Evaluation of iodine/creatinine ratios of casual samples as indices of daily urinary iodine output during field studies. J Clin Endocrinol Metab 1965; 25: 540-542
61 Ministry of Health and Welfare, Centers for Disease Control. Progress report II of KHANES 2007; 2009
62 Braverman LE, Woeber KA, Ingbar SH. Induction of myxedema by iodide in patients euthyroid after radioiodin or surgical treatment of diffuse toxic goiter. N Engl J Med 1969; 281(15): 816-821
63 Roti E, Minelli R, Gardini E, Braverman LE. The use and misuse of thyroid hormone. Endocr Rev 1993; 14(4): 401-423
64 Paul T, Meyers B, Witorsch RJ, Pino S, Chipkin S, Ingbar SH, Braverman LE. The effect of small increases in dietary iodine on thyroid function in euthyroid subjects. Metabolism 1988; 37(2): 121-124
65 Nath SK, Moinier B, Thuillier F, Rongier M, Desjeux JF. Urinary excretion of iodide and fluoride from supplemented food grade salt. Int J Vitam Nutr Res 1992; 62: 66-72
66 Martino E, Safran M, Aghini-Lombardi F, Rajatanavin R, Lenziardi M, Fay M, Pacchiarotti A, Aronin N, Macchia E, Haffajee C, Odoguardi L, Love J, Bigalli A, Baschieri L, Pinchera A, Braveraman L. Environmental iodine intake and thyroid dysfunction during chronic amiodarone therapy. Ann Intern Med 1984; 101(1): 28-34
67 Suzuki M, Tamura T. Iodine intake of Japanese male university students: Urinary iodine excretion of sedentary and physically active students and sweat iodine excretion during exercise. J Nutr Sci Vitaminol (Tokyo) 1985; 31: 409-415
68 Knobel M, Medeiros-Neto G. Relevance of iodine intake as a reputed predisposing factor for thyroid cancer. Arq Bras Endocrinol Metabol 2007; 51(5): 701-712
69 Vagenakis AG, Downs P, Braverman LE, Burger A, Ingbar SH. Control of thyroid hormone secretion in normal subjects receiving iodides. Clin Invest 1973; 52(2): 528-532
70 Braverman LE, Ingbar SH, Vagenakis AG, Adams L, Maloof F. Enhanced susceptibility to iodide myxedema in patients with Hashimoto's disease. J Clin Endocrinol Metab 1971; 32(4): 515-521
71 Braverman LE, Ingbar SH, Vagenakis AG, Adams L, Maloof F. Enhanced susceptibility to iodide myxedema in patients with Hashimoto's disease. J Clin Endocrinol Metab 1971; 32(4): 515-521
72 Kim JY, Moon SJ, Kim KR, Sohn CY, Oh JJ. Dietary iodine intake and urinary iodine excretion in normal Korean adults. Yonsei Med J 1998; 39(4): 355-362
73 Safran M, Paul TL, Roti E, Braverman LE. Environmental factors affecting autoimmune thyroid disease. Endocrinol Metab Clin North Am 1987; 16(2): 327-342
74 Namba H, Yamashita S, Kimura H, Yokoyama N, Usa T, Otsuru A, Izumi M, Nagataki S. Evidence of thyroid volume increase in normal subjects receiving excess iodide. J Clin Endocrinol Metab 1993; 76(3): 605-608
75 Konno N, Makita H, Yuri K, Iizuka N, Kawasaki K. Association between dietary iodine intake and prevalence of subclinical hypothyroidism in the coastal regions of Japan. J Clin Endocrinol Metab 1994; 78: 393-397
76 Jubiz W, Carlile S, Lagerquist LD. Serum thyrotropin and thyroid hormone levels in humans receiving chronic potassium iodide. J Clin Endocrinol Metab 1977; 44(2): 379-382