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Effect of Dietary Iron Levels on Lipid Metabolism, Antioxidative and Antithrombogenic Capacities in 16-month-old Rats  

김순기 (이화여자대학교 식품영양학과)
박주연 (이화여자대학교 식품영양학)
김미경 (이화여자대학교 식품영양학과)
Publication Information
Journal of Nutrition and Health / v.37, no.4, 2004 , pp. 273-280 More about this Journal
Abstract
This study was conducted to examine the effect of dietary iron levels on lipid metabolism, antioxidative and antithrombogenic capacities in 16-month-old rats. Thirty-two Sprague-Dawley male 16-month-old rats weighing 618 $\pm$ 6 g were raised for 10 days with medium-iron diet (35 ppm in diet) and blocked into 4 groups according to their body weights. One of groups was sacrificed to obtain initial data and the rest 3 groups were raised for 3 months with experimental diets containing different levels of iron (5 ppm, 35 ppm, and 350 ppm). Total lipid, triglyceride and total chole-sterol concentrations in plasma and liver, HDL-cholesterol concentration in plasma, fecal total lipid triglyceride and total cholesterol excretions, thiobarbituric acid reactive substances (TBARS) level in plasma LDL + VLDL (low density lipoprotein + very low density lipoprotein) fractions, blood-clotting time and eicosanoids levels in plasma were measured. The results are as follows: Plasma total lipid, triglyceride and total cholesterol concentrations, TBARS level in plasma LDL + VLDL fractions were increased and blood-clotting time tended to be shortened during 3 months of experimental period. Low (5 ppm) iron diet improved lipid metabolism via increasing HDL-cholesterol and fecal choles-terol excretion. High (350 ppm) iron diet decreased plasma total lipid, triglyceride and total cholesterol concentrations as compared to medium (35 ppm) iron diet and lowered body weight and epididymal fat pad weight. On the other hand, TBARS level in plasma LDL + VLDL fractions and blood-clotting time were increased with high iron diet. It is plausible that low iron diet improves lipid metabolism, antioxidative and antithrombogenic capacities in 16-month-old rats.
Keywords
iron; lipid metabolism; antioxidative capacity; antithrombogenic capacity; aged rats.;
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Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 A rapid method for total lipid extraction and purification /
[ Bigh,E.G.;Dyer,W.J. ] / Can J Biochem Physiol   DOI
2 /
[ KIm,U.K.;Lham,H.W.;Park,Y.S.;Myoung,S.O.;Lee,K.W. ] / Nutrition across the life span
3 Effect of Hepatic Iron on Hypercholesterolemia and Hypeririacylglycerolemia in Copper-Deficient Fructose-Fed Rats /
[ Bureau,I.;Lewis,C.G.;Fields,M. ] / Nutr   DOI
4 Coordinate transcriptional and translational regulation of ferritin response to oxidative stree /
[ Tsuji,Y.;Ayaki,H.;Whitman,S.P.;Morrow,C.S.;Torti,S.V.;Torti,F.M. ] / Molecular & cellular biology   DOI   ScienceOn
5 Spontaneous iron overload in Sprague Daweley rats /
[ Masson,R.;Roome,N.O ] / Toxical Patho
6 Non-anemic iron deficiency, oral iron supplementation, and oxidative damage on college-aged females /
[ Sareen S. Gropper;Sata Kerr;Jerrey M. Barksdale ] / J Nutu Biochem   DOI   ScienceOn
7 High stored iron levels are associated with excess risk of myocardial infarction in eastem Finnish men /
[ Salonen,J.T.;Nyyssonen,K;Korpela,H.;Tuomilehto,J.;Seppanen,R.;Salonen,R. ] / Circulation   DOI   ScienceOn
8 Determination of HDL₂cholesterol by precipitation with dextran sulfate and magnesium chloride establishing optimal conditions for rat plasma /
[ Sjoblom,L.;Eklund,A. ] / Lipids   DOI   ScienceOn
9 Iron indexes and total antioxidant status in response to soy protein intake in perimenpopausal women /
[ Swain,J.H.;Aleker,D.L.;Dent,S.B.;Peterson,C.T.;Reddy,M.B. ] / Am J Clin Nutr
10 Effect of grape intakes on lipid metabolism of rats during aging /
[ Um,M.Y.;Kim,M.K. ] / Kor J Nutr   과학기술학회마을
11 High dietary iron concentrations enhance the formation of cholesterol oxidation products in the liver of adult rats fed salmon oil with minimal dffects on antioxidant status /
[ Brandsh,C.;Ringeseis,R.;Eeder,K. ] / J Nutr
12 Inhibition on platelet aggregation and eicosanoid production by phenolic components of olive oil /
[ Petroni,A.;Blasevich,M.;Salami,M.;Papini,N.;Montedoro,G.F.;Galli,C. ] / Thrombosis Res   DOI   ScienceOn
13 Very high aplha-tocopherol diet diminishes oxidative stress and hypercoagulation in hypertensive rats but not in normotensive rat /
[ Ferenoux,J.M.;Noirot,B.;Prost,E.D.;Modani,S.;Blond,J.P.;Prost,J.L. ] / Med Sci Monit
14 Iron overload-prevalence and impact on heat /
[ Lynch,S.R. ] / Nutr Rev   DOI   ScienceOn
15 Iron stores and cadiovascular disease risk factors in women of reproductive age in United States /
[ Ramakishnan,U.;Kuklina,E.;Stein,A.D. ] / Am J Clin Nutr
16 /
[ Lauffer,R.B. ] / Iron and human disease
17 Iron overload diminishes atherosclerosis in apoE-deficient mice /
[ Kirk,E.A.;Heinecke,J.W.;LeBoeuf,R.C. ] / J Clin Invest   DOI   ScienceOn
18 Hepatic lipid peroxidation in vivo in rats with chronic iron overload /
[ Bacon,B.R.;Tavill,A.S.;Brittenhan,G.M.;Park,C.H.;Recknagel,R.O. ] / J Clin Invest   DOI
19 Chronic iron administration increases vascular oxidative stress and accelerates arterial thrombosis /
[ Day,S.M.;Duquaine,D.;Lakshmi,V.;Menon,R.G.;Khan,B.V.;Rajagopalan,S. ] / Circulation
20 Protein measurement with folin phenol regent /
[ Lowry,O.H.;Rosebrough,N.J.;Farr,A.L.;Randle,R.J. ] / J Biol Chem
21 Both iron deficiency and daily iron supplements increase lipid peroxidation in rat /
[ Michell,D.;Knutson,P.B.;Walter,B. ] / J Nutr
22 Iron overload in hyper cholesrelemic rats affects iom homeostasis and serum lipids but not blood pressure /
[ Turbina-Riberio SML;Silva,M.E.;Chianca,D.A.;De Paula H Jr;Cardos,L.M.;Colombari,E.;Pedosa,M.L. ] / J Nutr
23 A colorimetric method for determination of total serum liqid based on the sulfuric-phospho-vanillin reaction /
[ Frings,C.S.;Dunm,R.T. ] / Am J Clin Nutr
24 /
[ Statistical Office ] / 2001 Yearbook of Death Cause Statistic
25 The antithrombotic effects of green tea, Catechin /
[ Yun,E.P.;Kang,O.S.;Lee,M.A. ] / Fd Hyg Safety   과학기술학회마을
26 Gropper. Advanced Nutrition and Human Metabolism third edition /
[ Groff,J.L.;Sareen,S. ] / Wadsworth
27 Iron and the liver subcellular distribution of iron and decreased microsomal cytochrome P490 in livers of iron-loaded rats /
[ Bonkowsky,F.L.;Carpenter,S.J.;Healey,J.F. ] / Arch Pathol Lab Med
28 /
[ Kim,S.H.;Kim,H.Y. ] / Aging
29 Effect of dietary iron and selenium levels on lipid levels of rats fed cholesterol diet /
[ Jung,Y.S.;Sung,C.J. ] / J Kor Nutr
30 Flavonoids: a review of probable mechanisms of action and potential applications /
[ Njiveldt,R.J.;Nood,E.;Hoom,D.E.C.;Boelens,P.G.;Norren,K.;Leeuwen,P.A.M. ] / Am J Clin Nurt
31 AIN-93 Purified diets for laboratory rodents: final report of the American Institute Nutrition Ad Hoc Wrighting Committee on the reformulation of AIN-76A rodent diet /
[ Reeves,P.G.;Neilsen,F.H.;Fahey,G.C. ] / J Nutr