Browse > Article

Effects of Edible and Medicinal Plants Intake on Blood Glucose, Glycogen and Protein Levels in Streptozotocin Induced Diabetic Rats  

임숙자 (덕성 여자대학교 자연과학대학 식품영양학과)
한혜경 (덕성 여자대학교 자연과학대학 식품영양학과)
고진희 (덕성 여자대학교 자연과학대학 식품영양학과)
Publication Information
Journal of Nutrition and Health / v.36, no.10, 2003 , pp. 981-989 More about this Journal
Abstract
The hypoglycemic effects of four edible plants (Angelicae tenuissimae (A. ten.), Pleurospermum kamtschaticum (P. kam.), Adenophora remotiflora (A. rem.) and Zanthoxylum schinifolium (Z. sch.)) in streptozotocin (STZ) -induced diabetic rats were investigated. Sprague-Dawley male rats weighing 190-230 g were induced diabetes mellitus by the STZ injection (45 mg/kg) into the tail vein and were divided into six groups ; normal, STZ-control and four edible plant groups (A. ten., P kam., A. rem. and Z. sch. groups). Normal and STZ-control groups were fed a AIN-93 diet and four groups of STZ-induced diabetic rats were fed one of each experimental diets containing 10％ of the edible plant powder for 4 weeks. Diabetic rats showed the lower weight gain compared to the normal rats. In experimental groups except P. kam., AST activities were close to normal. A. ten. group were lowered ALT activities slightly. The plasma glucose levels of the diabetic experimental groups were significantly decreased at 4th week. The plasma insulin levels in diabetic experimental groups were not significantly different compared to the STZ-control group. The liver glycogen levels in STZ injected rats were significantly lower in compared to the normal rats. However no significant differences were found in response experimental plants intake in diabetic rats. The muscle glycogen were not significantly different among all the groups.
Keywords
Angelicae tenuissimae; Pleurospermum kamtschaticum; Adenophora remotiflora; Zanthoxylum schinifolium; streptozotocin-induced diabetic rats; hypoglycemic effect;
Citations & Related Records
Times Cited By KSCI : 14  (Citation Analysis)
연도 인용수 순위
1 Traditional plant medicines as treatments for diabetes /
[ Bailey,C.J.;Day,C. ] / Diabetes Care   DOI   ScienceOn
2 /
[ Yoon,K.B.;Jang,J.K. ] / Wild vegetables good for health
3 Vitamin E and the susceptibility of erythrocytes and reconstituted liposomes to oxidative stress in aged diabetics /
[ Urano,S.;Midori,H.H.;Tochihi,N.;Matsuo,M.;Shraki,M. ] / Lipids   DOI   ScienceOn
4 Effects of the components and extracts of some edible and medicinal plants on the formation of lipid peroxide in rat liver homogenate /
[ Park,J.C.;Chung,S.K.;Hur,J.M.Lee,J.H.;Choi,M.R.;Song,S.H.;Choi,J.W. ] / J Korean Soc Food Sci Nutr   과학기술학회마을
5 STZ diabetes alters immunoreactive β-endorphin levels and pain perception after 8wk in female rats /
[ Forman,S.;Estilow,M.L.;Vailenko,P. ] / Diabetes   DOI   ScienceOn
6 Further screening for antioxident activity of vegetable plants and its active principles from Zanthoxylum schinifolum /
[ Mun,S.I.;Ryu,H.S.;Lee,H.U.;Choi,J.S. ] / J Korean Soc Food Nutr   과학기술학회마을
7 Development of beverages drinks using mountain edible herbs /
[ Ham,S.S.;Lee,S.Y.;Oh,D.H.;Kim,S.H.;Hong,J.K. ] / J Korean Soc Food Sci Nutr   과학기술학회마을
8 Antiproliferative effects of the traditional chinese medicine shimotsu-to. Its component cnidium rhizome and derived compounds on primary cultures of mouse aorta smooth muscle cells /
[ Shinjiro,K. ] / Japan J Pharmacol   DOI
9 Inhibitory effects of tetramethyl pyrazine and ferulic acid on spontaneous movement of rat uterus in situ /
[ Ozaki,Y.;Ma,J. ] / Chem Pharm Bull   DOI   ScienceOn
10 The trend of food and nutrition intakes of Korean (1969-1989) /
[ Park,M.A.;Kim,E.S.;Lee,K.H.;Moon,H.K.;Song,I.J.;Tchai,B.S. ] / J Korean Soc Food Nutr
11 Renal proteinases and kidney hypertrophy in experimental diabetes /
[ Schaefer,L.;Schaefer,R.M.;Ling,H.;Teschner,M.;Heidland,A. ] / Diabetologia   DOI   ScienceOn
12 Protein measurement with the foline phenol reagent /
[ Lowry,O.H.;Rosebrough,N.J.;Farr,A.J.;Randall,R.R. ] / J Bio Chem
13 /
[ Bauer,J.D. ] / In clinical laboratory methods(9th ed.)
14 Effects of buckwheat on organ weight, glucose and lipid metabolism in streptozotocin-induced diabetic rats /
[ Lee,J.S.;Son,H.S.;Maeng,Y.S.;Chang,Y.K.;Ju,J.S. ] / J Korean Nutr   과학기술학회마을
15 The molecular mechanism of insulin action /
[ Kahn,C.R. ] / Ann Rev Med
16 Chemical structure-activity of cnidium rhizome-derived phthalides for the competence inhibition of proliferation in primary culture of mouse aorta smooth muscle cells /
[ Shinjiro,K. ] / Japan J Pharmacol   DOI
17 Studies on the minor components of the native wild herbs growing in the mountains of Kangwon Province (Ⅰ) /
[ Lee,W.;Jeong,K.J.;Lee,H.S.;Oh,H.S.;Choi,K.Y.;Jeong,E.H. ] / Rep Inst Health Environ
18 Phenylethanolamin N-methyltransferase in the basis of STZ diabetic rats /
[ Fisher,K.J.;Stewart,J.K. ] / Endocrinology   DOI   ScienceOn
19 /
[ National Statistical Office ] / Annual report on the cause of death statistics
20 /
[ Rao.M.;Blane,K.;Zonnenberg,M. ] / PC-STAT.
21 A preliminary study on hypocholesterolemic and hypoglycemic activities of some medicinal plant /
[ Choi,J.S.;Chung,H.Y.;Young,H.S. ] / Korean J Pharmacogn
22 Dietary sorbose prevents and improves hyperglycemia in genetically diabetic mice /
[ Furuse,M.;Kimura,C.;Mabayo,R.T.;Takahashi,H.;Okumara,J. ] / J Nutr
23 Physiologic mechanism in the development of starvation ketosis in man /
[ Grey,N.J.;Karls,I.;Kipnis,D.M. ] / Diabetes   DOI   ScienceOn
24 Effects of vitamin E and selenium on the antioxidative defense system in streptozotocin-induced diabetic rats /
[ Lee,S.J.;Choe,W.K.;Cha,B.K.;Yang,J.A.;Kim,K.Y. ] / Korean J Nutr   과학기술학회마을
25 /
[ Lee,S.J. ] / Korean Folk Medicine-Monographs Series
26 Development of Food Industry and Our Food Life /
[ Guen,R.W.;Kang,S.K. ] / Korean Food Culture Academy Autumn Scholarship Conference
27 Regulation of glucose metabolism in livers and kidneys of NOD mice /
[ Sococher,M.;Kunjara,S.;Baquer,N.Z.;Mclean,P. ] / Diabetes   DOI   ScienceOn
28 Effect of streptozotocin diabetes and insulin treatment on the rate of protein synthesis in tissues of the rat in vivo /
[ Pain,V.M.;Garlick,P. ] / J Bio Chem
29 The effects of nicotinamide on the serum lipid composition in streptozotocin-induced diabetic rats /
[ Choi,J.W.;Shon,K.H.;Kim,S.H. ] / J Korean Soc Food Nutr   과학기술학회마을
30 Effect of okcheonsan on blood glucose, lipid and protein levels streptozotocin-induced diabetic female rats /
[ Koh,J.B.;Kim,J.Y. ] / J Korean Soc Food Sci Nutr   과학기술학회마을   DOI
31 /
[ The Bureau of Statistics ] / Statistical annual of mortality cause
32 Studies on the antitumor promoting activity of naturally occurring substances Ⅱ. Inhibition of tumor promoter enhanced phospholipid metabolism by umbelliferous materials /
[ Okuyama,T.;Takata,M.;Nishiro,H.;Nishiro,A.;Takayasu.J. ] / Chem Pharm Bull (Tokyo)   DOI   ScienceOn
33 /
[ Campbell,R.K.;Steil,C.F. ] / Diabetes, clinical pharmacy and therapeutics(4th ed.)
34 Antioxidative activities of methanol extracts of tropical and oriental medicinal plants /
[ Choi,W.S.;Lee,S.E.;Lee,H.S.;Lee,Y.H.;Park,B.S. ] / Agricultural Chem Bio
35 On the enzymatic determination of blood glucose /
[ Raabo,E.;Terkildsen,T.C. ] / Scandinav J Lab Invest
36 Identification of glucokinase as an alloxan-sensitive glucose senssor of the pancreatic β-cells /
[ Meglasson,M.D.;Burch,P.T.;Berner,D.K.;Najafi,H.;Matschinsky,F.M. ] / Diabetes   DOI   ScienceOn
37 Studies of the diabetogenic action of streptozotocin /
[ Junod,A.;Lambert,A.E.;Orci,L.;Picet,R.;Gonet,A.E.;Renold,A.E. ] / Proc Soc Exp Biol Med   DOI
38 /
[ Choi,M.S. ] / Influence of body fat distribution on glucose tolerance and serum lipids in patient with non-insulin dependent diabetes mellitus
39 Oxidative stress in experimental diabetes induced by streptozotocin /
[ Matkovics,B.;Kotorman,M.;Varga,I.S.;Hai,D.Q.;Varga,C. ] / Acta Physiol Hung
40 Skeletal muscle vascular transport capacity in diabetic rats /
[ Sexton,W.S. ] / Diabetes   DOI   ScienceOn
41 Vasopressin in rats with genetic and streptozotocin-induced diabetes /
[ Brooks,D.P.;Nutting,D.F.;Crofton,J.L.;Share,L. ] / Diabetes   DOI   ScienceOn
42 Studies on the Cultivation of Pleuropermum kamtschaticum Hoff. as a special vegetable indigenous to high land area, 1. Ecological characteristics and environments concerning cultivation of Pleurospermum kamtschaticum Hoff /
[ Kim,J.H.;Hong,C.K.;Hong,D.G.;Bang,S.B.;Yoo,K.O. ] / RDA. J Agri Sci
43 Screening of Biologically Active Essential Oils from ligusticum tenuissimum /
[ Kim,M.H.;Kim,Y.G.;Lee,J.H.;Hong,K.P.;Hong,J.K.;Kong,Y.J.;Lee,H.Y. ] / Korean J Appl Microbiol Bio   과학기술학회마을
44 Analysis of volatile flavor components of Pleurospemum kamtschaticum /
[ Chung,M.S.;Lee,M.S. ] / Korean J Soc Food Sci   과학기술학회마을
45 /
[ Narle,A.;Krall,L.P.;Bradley,R.F.;Christlieb,A.R.;Soell,J.S.;Joslin's ] / Diabetes melitus(12th ed.)
46 Determination of serum protein by means of the biuret reaction /
[ Gornall,A.G.;Bardawill,C.S.;David,M.M. ] / J Bio Chem
47 A study on the qualitative and quantitative analysis of essential oil in Angelicae tenuissimae Radix or Ligustici rhizoma /
[ Park,H.K;Lee,S.I.;Lee,S.H.;Park.H.M.;Rhee,J.S. ] / Korean J Food Sci Technol
48 Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassays /
[ Desbuquois,B.;Aurbach,G.B. ] / J Clin Endocrinol Metab   DOI
49 Effects of raw soy flour (yellow and black) on serum glucose and lipid concentration in streptozotocin-diabetic rats /
[ Koh,J.B. ] / J Korean Soc Food Sci Nutr   과학기술학회마을
50 Chemical procedures for analysis of polysaccharides /
[ Hassid,W.Z.;Abraham,X. ] / Methods in Enzymology   DOI
51 /
[ W.B.Saunders Co. ] / Medical laboratory technology and clinical pathology(2th ed.)
52 A newly isolated antispasmodic-butylidenephthalide /
[ Ko,W. ] / Japan J Pharmacol   DOI
53 Effects of raw soy flour (yellow and black) on serum protein concentrations and enzyme activity in streptozotocin-diabetic rats /
[ Rho,M.H.;Cho,M.A.;Koh,J.B. ] / J Korean Soc Food Sci Nutr   과학기술학회마을
54 The screening of plants for hypoglycemic action in normal and alloxan-induced hyperglycemic rats /
[ Kim,O.K.;Lee,E.B. ] / Korean J Pharmacogn
55 Diabetogenic action of streptozotocin: Relationship of dose to metabolic response /
[ Junod,A.;Lambert,A.E.;Stauffacher,W.;Renod,A.E. ] / J Clin Invest   DOI
56 Components of the AIN-93 diets as improvements in the AIN-76A diet /
[ Reeves,P.G. ] / J Nutr
57 Pretreatment with nicotinamide to prevent the pancreatic enzymes changes by streptozotocin in rat /
[ Shon,K.H.;Kim,S.H.;Choi,J.W. ] / J Korean Soc Food Nutr   과학기술학회마을
58 A colorimetric method the determination of serum glutamic oxaloacetic and glutamin pyruvic transaminases /
[ Retiman,S.;Frankel,S.A. ] / Am J Clin Pathol
59 Inhibition effects of Zanthoxylum schinifolium and its active principle on lipid peroxidation and liver damage in carbon tetrachloride-treated mice /
[ Mun,S.I.;Ryu,H.S.;Choi,J.S. ] / J Korean Soc Food Sci Nutr   과학기술학회마을
60 Renal kallikrein and hemodynamic abonormalities of diabetic kidney /
[ Harvey,J.N.;Jaffa,A.A.;Margolium,H.S.;Mayfield,R.K. ] / Diabetes   DOI   ScienceOn
61 Renal hypertrophy in experimental diabetes: changes in pentose phosphate pathway activity /
[ Steer,K.A.;Sochor,M.;McLean,P. ] / Diabetes   DOI   ScienceOn