Browse > Article

The Comparative Study of Leptin and Insulin Levels to Adiposity-Associated Indices in Elementary School Children  

황권증 (창원대학교 자연과학대학 식품영양학과)
이경혜 (창원대학교 자연과학대학 식품영양학과)
Publication Information
Journal of Nutrition and Health / v.35, no.7, 2002 , pp. 737-742 More about this Journal
Abstract
To evaluate the effect of obesity on serum leptin and insulin levels in 80 elementary school children (aged 10.8 yr, 47 boys, 33 girls), we collected the anthropometric data and measured serum leptin and insulin levels. Serum leptin level and insulin resistance are known as factors which are associated with obesity and obesity related diseases such as diabetes, cardiovascular disease, hypertension. The results were as follows. The serum levels of insulin (p<0.001), leptin (p<0.001) and HOM $A_{IR}$ (p<0.001) in obese group were significantly higher than those of other groups. The obesity indices correlated significantly to serum levels of insulin and leptin, but not to fasting glucose level. These results suggested that circulating leptin and insulin concentrations may act as a humoral signal indicator to adiposity-associated metabolic disorder in elementary school children.
Keywords
leptin; insulin; children; obesity index; anthropometric data;
Citations & Related Records
Times Cited By KSCI : 6  (Citation Analysis)
연도 인용수 순위
1 The effect of leptin to glucose metabolism /
[ Choi WH ] / J Korean Diabetes Assoc
2 Rapid westernization of children's blood cholesterol in 3 countries: evidence for nutrient-gene interactions? /
[ Couch SC;Cross AT;Kida K;Ros E;Plaza I;Shea S;Deckelbaum R ] / Am J Clin Nutr
3 Leptin: a potent inhibitor of insulin secretion /
[ Fehmann HC;Peiser C;Bode HP;Stamm M;Staats P;Hedetoft C;Lang RE;Gke B ] / Peptides   DOI   ScienceOn
4 A long term observation of total cholesterol, blood pressure, BMI and blood glucose concerned with dietary intake /
[ Kim IS;Seo EA ] / Korean J Community Nutrition   과학기술학회마을
5 Plasma IGF-1 binding proteins in lean and obese non-diabetic subjects /
[ Tappy L;Jan C;Temler E ] / Int J Obes Relat Metab Disord
6 Insulin stimulates both leptin secretion and production by rat white adipose tissue /
[ Barr VA;Malide D;Zamowski MJ;Taylor SI;Cushman SW ] / Endocrinology   DOI   ScienceOn
7 Leptin suppressed during infusion of recombinant human insulin-like growth factor Ⅰ(rhlGF Ⅰ) in normal rats /
[ Bni-Schnetzler M;Hauri C;Zapf J ] / Diabetologia   DOI   ScienceOn
8 Leptin expression and action : New experimental paradigms /
[ Flier JS ] / Proc Natl Acad Sci
9 Standard for Physical development of children and adolescents in Korea /
[] / Korean J Pediatr Soc
10 Primary prevention of coronary heart disease in women through diet and lifestyle /
[ Shapiro JS;Kessler KM;Stampfer MJ;Hu FB;Willett WC ] / N Engl J Med   DOI
11 Beta-cell function evauated by HOMA as a predictor of secondary sulphonylurea failure in Type 2 diabetes /
[ Taverna MJ;Pacher N;Bruzzo F;Slama G;Selam JL ] / Diabetic Medicine   DOI   ScienceOn
12 Is leptin an insulin counter-regulatory hormone? /
[ Remesar X;Rafecas I;Fernandez-Lopez JA;Alemany M ] / FEBS Letters   DOI   ScienceOn
13 Role of insulin resistance in human disease /
[ Reaven GM ] / Diabetes
14 Leptin concentration in diabetin and non-diabetin subjects in the community population /
[ Kim YI;Chung YE;Kim JY;Kim SW;Lee MS;Park JY;Hong SK;Lee KU ] / J Korean Diabetes Assoc
15 Obesity, leptin and blood pressure among children in Taiwna: The taipei children's heart study /
[ Chu NF;Wang D;Shieh SM ] / Am J Hypertens   DOI   ScienceOn
16 /
[ Choi, H ] / Nutrition(2th)
17 Positional cloning of the mouse obese gene and its human homologue /
[ Zhang Y;Proenca R;Maffei M;Barone M;Leopold L;Friedman J ] / Nature   DOI   ScienceOn
18 Human leptin: from an adipocyte hormone to an endocrine mediator /
[ Wauters M;Considine RV;Van Gaal LF ] / Eur J Endo   DOI   ScienceOn
19 Prevalence of insulin resistance in metabolic disorders. The Bruneck Study /
[ Bonora E;Kiechl S;Willeit J;Oberhollenzer F;Egger G;Targher G;Alberiche M;Bonadonna RC;Muggeo M ] / Diabetes   DOI   ScienceOn
20 Visceral fat, insulin sensitivity, eand lipids in prepubertal children /
[ Gower BA;Nagy TR;Goran MI ] / Diabetes   DOI   ScienceOn
21 Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men /
[ Chu NF;Spiegelman D;Hotamisligil GS;Rifai N;Stampfer M;Rimm EB ] / Atherosclerosis
22 Insulin stimulates both leptin secretion and production by rat white adipose tissue /
[ Barr VA;Malide D;Zamowski MJ;Taylor SJ;Cushman SW ] / Endocrinology   DOI   ScienceOn
23 Prevalence of impaired glucose tolerance amone children and adolescents with marked obesity /
[ Sinha R;Fisch G;Teague B;Tamborlane WV;Banyas B;Allen K;Savoye M;Rieger V;Taksali S;Barbetta jG;Sherwin RS;Caprio S ] / N Engl J Med   DOI   ScienceOn
24 Neuroendocrine regulation and action of leptin /
[ Casanueva FF;Dieguez C ] / Frontiers in Neuroendocrinology   DOI   ScienceOn
25 Mechanisms of insulin resistance in noninsulin-dependent diabetes mellitus (NIDDM) /
[ Kim JW ] / J Korean Diabetes Assoc
26 A study on serom leptin concentration by obesity index in male college students in Korea /
[ Kim YS;Kim SK;Kim HJ ] / Korean J Nutr   과학기술학회마을
27 Plasma leptin concentrations: gender differences and associations with metabolic risk factors for cardiovascular disease /
[ Couillard C;Mauriege P;Prud'homme D;Nadeau A;Tremblay A;Bouchard C(et al.) ] / Diabetologia   DOI   ScienceOn
28 Comparisons of BMI, blood lipid profile, blood pressure and nutrient intakes by serum insulin concentrations /
[ Kim WK;Lee KA ] / Korean J Nutr   과학기술학회마을
29 Treatment approaches: Food first for weight management and health /
[ Blackburn GL ] / Obes Res   DOI
30 Leptin /
[ Auwerx J;Staels B ] / Lancet   DOI   ScienceOn
31 Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man /
[ Matthews Dr;Hosker JP;Rudenski AS;Naylor BA;Treacher DF;Turner RC ] / Diabetologia   DOI   ScienceOn
32 Letin and the regulation of body weight in mammals /
[ Friedman JM;Halaas JL ] / Nature   DOI   ScienceOn
33 Determinants of haemostatic risk factors for coronary heart disease in obese children and adolescents /
[ Gallistl S;Sudi KM;Borkenstein M;Troebinger M;Weinhandl G;Muntean W ] / Int J Obes   DOI
34 The adipose obese gene product, leptin: Evidence of a direct inhibitory role in ovarian function /
[ Spicer LJ;Francisco CC ] / Endocrinology   DOI   ScienceOn
35 Abdominal fat dopots measured by computed tomography:effects of degree of obesity, sex and age /
[ Seidell JC;Oosterlee A;Deurenberg P;Hautvast JG;Ruijs JH ] / Eur J Clin Nutr
36 The future of leptin and leptin analogues in the treatment of obesity /
[ Bryson JM ] / Diabetes, Obesity and Metabolism   DOI   ScienceOn
37 Mean fasting blood glucose level ansanans an estimated prevalence of diabetes mellitus among a representative adult Korean population /
[ Kim JS;Kim YJ;Park SI ] / Korean J of Preventive Medicine   과학기술학회마을
38 Evidence that plasma leptin and insulin levels are associated with body adiposity via different mechanism /
[ Schwartz MW;Prigeon RL;Kahn SE;Nicholson M;Moore J;Morawiecki A(et al.) ] / Diabetes Care   DOI   ScienceOn
39 The study of relationship among serum leptin, nutritional status, serum glucose lipids of middle school girls /
[ Kim MH;Sung CJ ] / Korean J Nutr   과학기술학회마을
40 UKPDS 20: Plasma leptin, obesity, and plasma insulin in type 2 diabetic subjects /
[ Widjaja A;Stratton IM;Horn R;Holman RR;Turner R;Brabant G ] / J Clin Endocrinol Metab   DOI   ScienceOn
41 A polymorphic marker in the leptin gene associated with Japanese morbid obesity /
[ Ohshiro Y;Ueda K;Nishi M;Ishigame M;Wakasaki H;Kawashima H;Furuta H;Sasaki H;Sanke T;Tokio N;Nanjo K ] / J Mol Med   DOI   ScienceOn
42 Weight-deducing effects of the plasma protein encoded the obese gene /
[ Halaas JL;Gajiwala K;Maffe M;Cohen SL;Chait BT;Rabinowitz D;Lallone RL;Burley SK;Friedman JM ] / Science   DOI
43 The influences of height and age on waist circumferences as an index of adiposity in adults /
[ Han TS;Seidell JC;Currall JE;Morrison CE;Deurenberg P;Lean ME ] / Int J Obes Relat Metab Disord
44 A study on relation of obesity to the serum lipid and insulin concentration in the elementary school children /
[ Kim SH;Kim GE;Kim SY ] / Korean J Nutr   과학기술학회마을
45 UKPDS 20: Plasma leptin, obesity, and plasma insulin in type 2 diabetic subjects /
[ Widjaja A;Stratton IM;Horn R;Holman RR;Tumer R;Brabant G ] / J Clin Endocrinol Metab   DOI   ScienceOn
46 Nutrient induced insulin resistance /
[ Proietto J;Filippis A;Nakhla C;Clark S ] / Molecular and Cellular Endocrinology   DOI
47 Estimation of deep abdominal adipose tissue accumulation from simple anthrophmetric measurments in men /
[ Despres J-P.;Prud'homme D;Pouliot MC;Tremblay A;Bouchard C ] / Am J Clin Nutr
48 Cultural considerations for treatment of childhood obesity /
[ Davis SP;Northington L;Kolar K ] / J Cult Divers