Browse > Article
http://dx.doi.org/10.7841/ksbbj.2011.26.2.126

Effects of Schizandra Cchinensis Fruit Extract on the Hyperglycemia and Hyperlipemia in Streptozotocin-induced Diabetic Rats  

Chae, Hee-Jun (Department of Biotechnology, Daegu University)
Lee, In-Soon (Department of Biotechnology, Daegu University)
Moon, Hae-Yeon (Department of Biotechnology, Daegu University)
Publication Information
KSBB Journal / v.26, no.2, 2011 , pp. 126-130 More about this Journal
Abstract
To investigate the antihyperglycemic and antihyperlipemic effect of 80% ethanol extract of Schizandra Chinensis fruit, we induced diabetes in the rats with streptozotocin (STZ) and administered schizandra extract or Acarbose to diabetic rats for 21 days by oral administration. Consequently, the groups treated using schizandra extract decreased blood glucose levels more 39% than no treatment group and the case of Acarbose group was decreased it about 21%. The concentration of cholesterol, triglyceride and LDL-C in blood was also decreased while treating schizandra extract, on the other hand, HDL-C concentration was significantly increased it about 26%. Those results induced that anti-atherogenic index (AAI) in blood was improved more than 82% level like normal condition, especially in treatment of schizandra extract 100 mg. The lipid profiled in feces was likewise showed apparent tendency to decrease and food efficiency ratio of diabetic rats was became higher for treatment with schizandra extract, but Acarbose group had low efficiency in compared with the result of glucose level and lipid profile in blood. As a result, schizandra extract is regard a good medicine for diabetes due to improve physical constitution, blood glucose and lipid level caused hyperglycemia and suggest that schizandra extract has real effects on the diabetes complication as atherosclerosis, coronary heart disease, high blood pressure.
Keywords
Schizandra Chinensis; hyperglycemia; Diabetes; hyperlipemia; anti-atherogenic index (AAI);
Citations & Related Records
Times Cited By KSCI : 6  (Citation Analysis)
연도 인용수 순위
1 Lee, Y. A., H. J. Chae, and H. Y. Moo (2005) Effect of hovenia dulcis THUNBER var koreana nakai fruits extracts on glucose, lipid metabolism and antioxidant activities in streptozotocin induced diabetic rat. J. Exp. Biomed. Sci. 11: 533-538.
2 Ko, B.S., S. k. Park, S. B. Choi, D. W. Jun, M. K. Choi, and S. M. Park (2004) A Study on Hypoglycemic Effects of Crude Extracts of Schizandrae Fructus. J. Korean Soc. Appl. Biol. Chem. 47: 258-264.
3 Furuse, M., C. Kimura, R. T. Mabayo, H. Takahashi, and J. Okumura (1993) Dietary sorbose prevents and improves hyperglycemia in genetically diabetic. J. Nutrition 59-65.
4 Kang S. M. (2003) Effect of saengshik supplementation on health improvement in diet-induced hypercholesterolemic rats. J. Korean Soc. Food Sci. Nutr. 32: 906-912.   DOI
5 Basu, M., R. Prasad, P. Jayamurthy, K. Pal, C. Arumughan, and R. C. Sauhney (2007) Anti-atherogenic effects of seabuckthorn seed oil. Phytomedicine 14: 770-777.   DOI   ScienceOn
6 Akiyama, T., S. Takasawa, K. Nata, S. Kobayashi, M. Abe, N. J. Shervani, T. Ikeda, K. Nakagawa, M. Unno, S. Matsuno, and H. Okamoto (2001) Activation of Reg gene, a gene for insulin producing ${\beta}$-cell regeneration: Poly (ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly (ADP-ribosyl) ation. Proc. Natl. Acad. Sci. USA. 98: 48-53.
7 Cohen, M. P., J. R. Vasselli, R. G. Neuman, and J. Witt (1995) Treatment with acarbose, an ${\alpha}$-glucosidase inhibitor, reduces increased albumin excretion in streptozotocin-diabetic rats. General Pharmacolog 26: 1355-1361.   DOI
8 Guido, S. and T. Joseph (1992) Effect of chemically different calcium antagonists on lipid profile in rats fed on a high fat diet. Ind. J. Exp. Biol. 30: 292-294.
9 Like, A. A. and A. A. Rossini (1976) Streptozotocin-induced pancreatic insulities: new model of diabetes mellitus. Science 193: 415-417.   DOI
10 Friedewald, W. T., R. I. Levy, and D. S. Fredrickson (1972) Estimation of the concentration of low-densitylipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18: 499-502.
11 Chae, H. J., H. I. Hwang, I. S. Lee, and H. Y. Moon (2005) Comparison of on rat intestinal digestive enzyme inhibitory activity and antioxidant enzyme activity of korean and chinese Schizandra chinensis. J. Exp. Biomed. Sci. 11: 517-523.
12 Kwon, H. J. and C. S. Park (2008) Biological activities of extracts from omija (Schizandra chinensis Baillon). Korean J. Food Preserv. 15: 587-592.
13 Choi, E. O., B. S. Lee, Y. S. Park, E. O. Seo, and B. W. Chung (2008) Extraction condition from Schizandra chinensis baillon for beverage development of high scizandrin concentration. Korean J. Biotechnol. Bioeng. 23: 271-275.
14 Kim, K. S., S. S. Kang, and S. N. Ryu (2002) Quantitative analysis of lignans from fruits of Schizandra chinensis. Kor. J. Pharmacogn. 33: 272-276.
15 Caspary, W. F., A. M. Rhein, and W. Creutzfeldt (1972) Increase of intestinal brush borderin mucosa of streptozotocin-diabetic rats. Diabetologia 8: 412-414.   DOI   ScienceOn
16 Mahesh, T., M. S. Balasubashini, and V. P. Menon (2005) Effect of photo-irradiated curcumin treatment against oxidative stress in streptozotocin-induced diabetic rats. J. Med. Food 8: 251-255.   DOI   ScienceOn
17 Stamler, J., O. Vaccaro, J. D. Neaton, and D. Wentworth (1993) Diabtes, other risk factors, and 12-yr cardiovascular mortality for men screened in the multiple risk factor intervention trial. Diabtes Care 15: 434-444.
18 Oh, C. H., J. N. So, S. J. Lee, and J. Kwon (2001) Effects of Schizandra chinensis fructus on the immunoregulatory action and apoptosis of L1210 cells. Korean J. Food Sci. Technol. 33: 384-388.
19 Ko, S.-H., S.-W. Choi, S.-K. Ye, S. H. Yoo, H.-S. Kim, and M.-H. Chung (2008) Comparison of anti-oxidant activities of seventy herbs that have been used in Korean traditional medicine. Nutr. Res. Pract. 2: 143-151.   DOI
20 Brown, W. V. (1994) Lipoprotein disorders in diabetes mellitus. Med. Clin. N. AM. 78: 143-61.   DOI
21 Gray, A. M. and P. R. Flatt (1997) Natural's own pharmacy: the diabetes perspective. Proc. Nutr. Soc. 56: 507-517.   DOI