Review on Anti-Cancer and Anti-Imflammatory Activity from Rubus coreanus Miquel
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Song, You-Na
(Laboratory of Food Safety and Toxicology, Department of Food Science and Nutrition, Hanyang University)
Lee, Heon-Ok (Laboratory of Food Safety and Toxicology, Department of Food Science and Nutrition, Hanyang University) Noh, Geon-Min (Functional Food and Nutrition Division, Department of Agrofood Resources, National Academy of Agricultural Science) Kim, Haeng-ran (Functional Food and Nutrition Division, Department of Agrofood Resources, National Academy of Agricultural Science) Choe, Jeong-Sook (Functional Food and Nutrition Division, Department of Agrofood Resources, National Academy of Agricultural Science) Om, Ae-Son (Laboratory of Food Safety and Toxicology, Department of Food Science and Nutrition, Hanyang University) |
1 | Yang HM, Oh SM, Lim SS, Shin HK, Oh YS, Kim JK (2008). Antiinflammatory activities of Rubus coreanus depend on the degree of fruit ripening. Phytother Res 22(1):102-107. DOI |
2 | Yoon I, Wee JH, Moon JH, Ahn TH, Park KH (2003). Isolation and identification of quercetin with antioxidative activity from the fruits of Rubus coreanum Miquel. Korean J Food Sci Technol 35(3):499-502. |
3 | Yoon TS, Cheon MS, Kim SJ, Lee AY, Moon BC, Chun JM, Choo BK, Kim HK (2010). Evaluation of solvent extraction on the anti-inflammatory efficacy of Glycyrrhiza uralensis. Korean Journal of Medicinal Crop Science 18(1):28-33. |
4 | Aggarwal BB, Shishodia S, Sandur SK, Pandey MK, Sethi G (2006). Inflammation and cancer: How hot is the link? Biochem Pharmacol 72(11):1605-1621. DOI |
5 | An YH, Kim YH (2007). Distribution and ecological characteristics of native Rubus coreanus in Korea. Kor J Env Eco 21(2):176-185. |
6 | Cha HS, Youn AR, Park PJ, Choi HR, Kim BS (2007). Physicochemical characteristics of Rubus coreanus Miquel during maturation. Korean J Food Sci Technol 39(4):476-479. |
7 | Bae GH (2000). The Medicinal Plant of Korea. Kyohasa Publishing Co., Ltd, Seoul, Korea. |
8 | Baek EY, Lee SM, Lee JE, Park EK, Kim YR, Jung IK, Kim JH (2013). Effect of Rubus coreanus Miquel on prostate tumour growth. Journal of Functional Foods 5(3):1478. DOI |
9 |
Boivin D, Blanchette M, Barrette S, Moghrabi A, Beliveau R (2007). Inhibition of cancer cell proliferation and suppression of TNF |
10 | Cho SH, Choi SW, Lee HR, Lee JY, Lee WJ, Choi YS (2004). Safety and effects on lipid parameters of Rubus coreanus and Atractylodes japonica in ovariectomized rats. J Food Sci Nutr 9(4):361-366. DOI |
11 | Choi HS, Kim MK, Park HS, Kim YS, Shin DH (2006). Alcoholic fermentation of Bokbunja(Rubus coreanus Miq.) wine. Korean J Food Sci Technol 38(4):543-547. |
12 | Choung MG, Lim JD (2012), Antioxidant, anticancer and immune activation of anthocyanin fraction from Rubus coreanus Miquel fruits (Bokbunja). Korean J Medicinal Crop Sci 20(4):259-269. DOI |
13 | Chung TH, Kim JC, Lee CY, Moon MK, Chae SC, Lee IS, Kim SH, Hahn KS, Lee IP (1997). Potential antiviral effects of Terminalia chebula, Sanguisorba officinalis, Rubus coreanus and Rheum palmatum against duck hepatitis B virus (DHBV). Phytotherapy Res 11(3):179-182. DOI |
14 | Gozzelino R, Jeney V, Soares MP (2010). Mechanisms of cell protection by heme oxygenase-1. Annu Rev Pharmacol Toxicol 50:323-354. DOI |
15 | Cipk L, Rauko P, Miadokov E, Cipkov I. Novotn L (2003). Effects of flavonoids on cisplatin-induced apoptosis of HL-60 and L1210 leukemia cells. Leuk Res 27(1):65-72. DOI |
16 | Downs-Holmes C, Silverman P (2011). Breast cancer: overview & updates. Nurse Pract 36(12):20-26. DOI |
17 | Elbirt KK, Bonkovsky HL (1999). Heme oxygenase: recent advances in understanding its regulation and role. Proc Assoc Am Physicians 111(5):438-447. DOI |
18 | Han JY, Kim YH, Sung JH, Um YR, Lee Y, Lee JS (2009). Suppressive effects of Chrysanthemum zawadskii var. latilobum flower extracts on nitric oxide production and inducible nitric oxide synthase expression. J Korean Soc Food Sci Nutr 38 (12):1685-1690. DOI |
19 | Jeon SG, Lee JW, Lee IS (2007). Effect of antioxidant activity and induction of DNA damage on human gastric cancer cell by Rubus coreanus Miquel. Journal of Life Science 17(12):1723-1728. DOI |
20 | Jeon YH, Choi SW, Kim MR (2009). Antimutagenic and cytotoxic activity of ethanol and water extracts from Rubus coreanum. Korean J Food Cookery Sci 25:379-386. |
21 | Jeong JS, Sin MK (1996). Encyclopedia of Oriental medical. Young Rim Republ., Seoul, Korea. |
22 | Jun YK, Kim MH, Seong PN, Chang MJ (2012). A comparison of anti-inflammatory activities of green tea and grapefruit seed extract with those of microencapsulated extracts. Korean J Nutr 45(5):443-451. DOI |
23 |
Kim S, Kim CK, LEe KS, Kim JH, Hwang H, Jeoung D, Choe J, Won MH, Lee H, Ha KS, Kwon YG. Kim YM (2013). Aqueous extract of unripe Rubus coreanus fruit attenuates atherosclerosis by improving blood lipid profile and inhibiting NF- |
24 | Jung JH, Kim KJ (2015). Anti-inflammatory effects of herbal medicines(Rubus coreanus, Rehmanniae Radix, Houttuynia cordata, Betulae cortex) EtOH extract on acute atopic dermatitis mice. J Korean Med Ophthalmol Otolaryngol Dermatol 28(1):68-84. DOI |
25 | Jung KW, Park S, Won YJ, Chang MO, Kong HJ, Cho HS (2015). Prediction of cancer incidence and mortality in Korea. Cancer Res Treat 44(2):25-31. |
26 | Kho MC, Lee YJ, Yon JJ, Kang DG, Lee HS (2015). Beneficial Effect of Rubus coreanus Miq in a rat model of high fructose diet-induced metabolic syndrome. J Physiol & Pathol Korean Med 29(1):11-17. DOI |
27 | Kim DH, Ahn BJ, Kim SG, Park TS, Park GH, Soh JH (2011). Anti-Inflammatory effect of Ligularia fischeri, Solidago virga-aurea and Aruncus dioicus complex extracts in Raw 264.7 cells. Journal of Life Schience 21(5):678-683. DOI |
28 | Kim EJ, Lee YJ, Shin HK, Park JH (2005). Induction of apoptosis by the aqueous extract of Rubus coreanum in HT-29 human colon cancer cells. Nutrition 21(11-12):1141-1148. DOI |
29 | Kim HJ, Kang KJ (2013). Inducing effects of rubus coreanus on cell death and apoptotic gene expressions in human breast cancer cells. J East Asian Soc Dietary Life 23(6):723-732. |
30 | Kim HS, Park SJ, Hyun SH, Yang SO, Lee J, Auh JH, Kim JH, Cho SM, Marriott PJ, Choi HK (2011). Biochemical monitoring of black raspberry (Rubus coreanus Miquel) fruits according to maturation stage by 1H-NMR using multiple solvent systems. Food Res Int 44(7):1977-1987. DOI |
31 | Kim JH, Kim CH, Kim HS, Kwon MC, Song YK, Seong NS, Lee SE, Yi JS, Kwon OW, Lee HY (2006). Effect of aqueous extracts from Rubus coreanus Miquel and Angelica gigas Nakai on anti-tumor and antistress activities in mice. Korean J Med Crop Sci 14(4):206-211. |
32 | Kim MS, Bang GC, Lee MW (1996). Tannins from the leaves of Rubus coreanum, Kor J Pharmacogn 40(6):666-669. |
33 | Kim MS, Bang GC, Lee MW (1997). Flavonoids from the leaves of Rubus coreanum. Kor J Pharmacogn 40(1):1-6. |
34 | Kim SK, Kim H, Kim SA, Park HK, Kim W (2013). Anti-inflammatory and anti-superbacterial activity of polyphenols isolated from black rasberry. Korean J Physiol Pharmacol 17(1):73-9. DOI |
35 | Kim SS (1998). A study on the related factors of Korean cancer - Outbreaks. J Korean Soc Health Inform Stat 23:1-16. |
36 | Kim Y, Kim J, Lee SM, Lee HA, Park S, Kim Y, Kim JH (2012). Chemopreventive effects of Rubus coreanus Miquel on prostate cancer. Biosci Biotechnol Biochem 76(4):737-44. DOI |
37 | Kleinsmith LJ (2008). Principles of Cancer Biology 1st ed. Life Science Publishing Co.,16-63, Seoul, Korea. |
38 | Kwon KH, Cha WS, Kim DC, Shin HJ (2006). A reserch and application of active ingredients in Bokbunja( Rubus coreanus Miquel). Korean J Biotechnol Bioeng 21(6):405-409. |
39 | Lee JE, Cho SM, Kim J, Kim JH (2013). Effects unripe and ripe Rubus coreanus Miquel on peritoneal macrophage gene expression using cDNA microarray analysis. Korean Soc Food Sci Nutr 42(10): 1552-1559. DOI |
40 | Lee HN, Lim DY, Lim SS, Kim JD, Yoon JH (2011). Antiinflammatory effect of ethanol extract from Eupatorium japonicum. Korean J Food Sci Technol 43(1):65-71. DOI |
41 | Lee KK, Han JH, Oh CH (2009). Effects of Rubus coreanus Miquel on the apoptosis of U937 cells. Korean J Oriental Physiology & Pathology 23(6): 1404-1408. |
42 | Lee MW(1995). Phenolic compounds from the Leaves of Rubus coreanum. Kor J Pharmacogn 39 (2):200-204. |
43 | Lee YA, Lee MW (1995). Tannis from Rubus coreanum. Kor J Pharmacogn 26(1):27-30. |
44 | Lewis C (1994). A review of the use of chemoprotectants in cancer chemotherapy. Drug Saf 11 (3):153-162. DOI |
45 | Links M, Lewis C (1999). Chemoprotectants: a review of their clinical pharmacology and therapeutic efficacy. Drugs 57(3):293-308. DOI |
46 | Mullen W, Mcginn J, Lean MEJ, Maclean MR, Gardner P, Duthie GG, Yokota T, Crozier A (2002). Ellagitannins, flavonoids, and other phenolics in red raspberries and their contribution to antioxidant capacity and vasorelaxation properties. J Agric Food Chem 50(18):5191-5196. DOI |
47 | Pang KC, Kim MS, Lee MW (1996). Hydrolyzable tannins from the fruits of Rubus coreanum. Kor J Pharmacogn 27(4):366-370. |
48 | Park EJ, Pezzuto JM (2002). Botanicals in cancer prevention. Cancer Metast Rev 21(3-4):231-255. DOI |
49 | Park MC, Kim KJ, Lee HS, Jo EH (2007). Attenuation of airway hyperreactivity(AHR) and inflammation by water extract of Rubus coreanus Miq.(WRCM). J Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology 20(1):177-194. |
50 | Park JH, Oh SM, Lim SS, Lee YS, Shin HK, Oh YS, Choe NH, Park JH, Kim JK (2006). Induction of heme oxygenase-1 mediates the anti-inflammatory effects of the ethanol extract of Rubus coreanus in murine macrophages. Biochem Biophys Res Commun 351(1):146-152. DOI |
51 | Park Y, Kim SH, Choi SH, Han J, Chung HG (2008). Changes of antioxidant capacity, total henolics, and vitamin C contents during Rubus coreanus fruit ripening. Food Sci Biotechnol 17(2):251-256. |
52 | Peter B, Bernard L (2008). World Cancer Report 2008. International Agency for Research on Cancer. 42-43. |
53 | Seeram NP, Herber D (2007). Impact of berry phytochemicals on human health: Effects beyond antioxidation. ACS Symposium Series 956(21):326-336. DOI |
54 |
Surh YJ, Na HK (2008). NF- |
55 | Tenhunen R, Marver HS, Schmidt R (1968). The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci USA 61(2):748-755. DOI |
56 | Tokalov SV, Abramyuk AM, Abolmaali ND (2010). Protection of p53 wild type cells from taxol by genistein in the combined treatment of lung cancer. Nutr Cancer 62(2):795-801. DOI |
57 | Xu Y, Xin Y, Diao Y, Lu C, Fu J, Luo L (2012). Synergistic effects of apigenin and paclitaxel on apoptosis of cancer cells. PLoS One 6(12):e29169. DOI |
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