Study on the Protective Mechanism of Vitamin C in the SH-SY5Y Cell Death Induced by the Streptozotocin
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Lee, Seung-Hee
(Research Institute, Seoul Medical Center)
Han, Kyung-Hoon (Research Institute, Seoul Medical Center) Kim, Hyun-Jun (Research Institute, Seoul Medical Center) Park, Kwang-Sung (Research Institute, Seoul Medical Center) Han, Sung-Hee (Biomedical Research Center, Korea University Anam Hospital) Kim, Jung-Hee (Dept. of Neurosurgery, Seoul Medical Center) Heo, Jae-Hyeok (Dept. of Neurology Seoul Medical Center) |
1 | Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C, Shi Y, Géliinas C, Fan Y, Nelson DA, Jin S, White E. 2006. Autophagypromotes tumor cell survival and restricts necrosis, inflammation and tumorigenesis. Cancer Cell 10:51-64 DOI |
2 | Du J, Cullen JJ, Buettner GR. 2012. Ascorbic acid: Chemistry, biology and the treatment of cancer. Biochim Biophys Acta 1826:443-457 |
3 | Gross A, McDonnell JM, Korsmeyer SJ. 1999. Bcl-2 familymembers and the mitochondria in apoptosis. Genes Dev 13:1899-1911 DOI |
4 | Heo HJ, Lee CY. 2005. Strawberry and its anthocyanins reduce oxidative stress-induced apoptosis in PC12 cells. J Agric Food Chem 53:1984-1989 DOI |
5 | Hoyer S. 1993. Abnormalities in brain glucose utilization and its impact on cellular and molecular mechanisms in sporadic dementia of Alzheimer type. Ann N Y Acad Sci 695:77-80 DOI |
6 | Hutton M, Perez-Tur J, Hardy J. 1998. Genetics of Alzheimer's disease. Essays Biochem 33:117-131 DOI |
7 | Jeong YS, Hwang BS, Cho SM, Hwang KA, Hwang IG. 2017. Antioxidant and anti-diabetic, anti-Alzheimer activities of stem from Opuntia ficus-indica var. saboten cultivated in Jeju at harvest time. Korean J Food Nutr 30:1332-1340 |
8 | Junod A, Lambert AE, Orci L, Pictet R, Gonet AE, Renold AE. 1967. Studies of the diabetogenic action of streptozotocin. Proc Soc Exp Biol Med 126:201-205 DOI |
9 | Kim MO, Jang SM. 2004. Effects of various proteins on the autoxidation of L-ascorbic acid. Korean J Food Nutr 17:294-301 |
10 | Knott AB, Perkins G, Schwarzendacher R, Bossy-Wetzell E. 2008. Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci 9:505-518 DOI |
11 | Sayers TJ. 2011. Targeting the extrinsic apoptosis signaling pathway for cancer therapy. Cancer Immunol Immunother 60:1173-1180 DOI |
12 | Cunnane S, Nugent S, Roy M, Courchesne-Loyer A, Croteau E, Tremblay S, Castellano A, Pifferi F, Bocti C, Paquet N, Begdouri H, Bentourkia M, Turcotte E, Allard M, Barberger-Gateau P, Fulop T, Rapoport SI. 2011. Brain fuel metabolism, aging, and Alzheimer's disease. Nutrition 27:3-20 DOI |
13 |
Masters CL, Beyreuther K. 2006. Alzheimer's centennial legacy: Prospects for rational therapeutic intervention targeting the |
14 |
Mattson MP, Partin J, Begley JG. 1998. Amyloid |
15 |
Park KJ, Gaynor RB, Kwak YT. 2003. Heat shock protein 27 association with the |
16 | Reynolds A, Lauriea C, Mosleya RL, Gendelmana HE. 2007. Oxidative stress and the pathogenesis of neurodegenerative disorders. Int Rev Neurobiol 82:297-325 |
17 | Wang C, Youle RJ. 2009. The role of mitochondria in apoptosis. Annu Rev Genet 43:95-118 DOI |
18 | Sisodia SS. 1999. Alzheimer's disease: Perspectives for the new millennium. J Clin Invest 104:1169-1170 DOI |
19 | Sotiriou S, Gispert S, Cheng J, Wang Y, Chen A, Hoogstraten-Miller S, Miller GF, Kwon O, Levine M, Guttentag SH, Nussbaum RL. 2002. Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. Nat Med 8:514-517 DOI |
20 | Stanciu M, Wang Y, Kentor R, Burke N, Watkins S, Kress G, Reynolds I, Klann E, Angiolieri MR, Johnson JW, DeFranco DB. 2000. Persistent activationof ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures. J Biol Chem 275:12200-12206 DOI |
21 | Kwon KH, Lim HY, Chung MJ. 2014. Neuroprotective effects of bread containing Cirsium setidens or Aster scaber. J Korean Soc Food Sci Nutr 43:829-835 DOI |
22 | Wohaieb SA, Godin DV. 1987. Starvation-related alterations in free radical tissue defense mechanisms in rats. Diabetes 36:169-173 DOI |
23 |
Younkin SG. 1998. The role of |
24 |
Zheng S, Zhao M, Ren Y, Wu Y, Yang J. 2015. Sesamin suppresses STZ induced INS-1 cell apoptosis through inhibition of NF- |
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