Effect of Lepidium spp. (Maca) Extract on the Improvement of Sexual Function in Rats Induced Erectile Dysfunction with Ethanol
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Choi, Hye Ran
(Berry & Biofood Research Institute)
Lee, Min Jung (World Institute of Kimchi) Lee, Su Jung (Berry & Biofood Research Institute) Park, Hee Jeon (Berry & Biofood Research Institute) Song, Ji-Young (Berry & Biofood Research Institute) Kim, Il Su (Gaonjig-i Farm) Shin, Daekeun (Berry & Biofood Research Institute) |
1 | AOAC. 2005. Official Methods of Analysis of the Association of Official Analytical Chemists. 18th ed. Association of Official Analytical Chemists |
2 | Baek BK, Jeong JC, Shin HC. 2008. Effects of Scolopendra on ethanol-induced erectile dysfunction in rat. Korean J Orient Physiol & Pathol 22:176-182 |
3 | Benet AE, Melman A. 1995. The epidemiology of erectile dysfunction. Urol Clin North Am 22:699-709 |
4 | Cicero AFG, Bandieri E, Arletti R. 2001. Lepidium meyenii Walp. improves sexual behaviour in male rats independently from its action on spontaneous locomotor activity. J Ethnopharm 75:225-229 DOI |
5 | Bredt DS, Ferris CD, Snyder SH. 1992a. Nitric oxide synthase egulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites. J Biol Chem 267:10976-10981 |
6 | Bredt DS, Hwang PM, Snyder SH. 1990b. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 347:768-770 DOI |
7 | Bustos-Obregon E, Yucra S, Gonzales GF. 2005. Lepidium meyenii (maca) reduces spermatogenic damage induced by a single dose of malathion in mice. Asian J Androl 7:71-76 DOI |
8 | Feelisch M, Noack E. 1987. Nitric oxide (NO) formation from nitrovasodilators occurs independently of hemoglobin or non-heme iron. Eur J Pharmacol 142:465-469 DOI |
9 | Friederich JA, Butterworth JF. 1995. Sodium nitroprusside: Twenty years and counting. Anesth Analg 81:152-162 |
10 | Furchegott RF. 1983. Role of endothelium in responses of vascular smooth muscle. Circ Res 53:557-573 DOI |
11 | Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA. 1998. Oral sildenafil in the treatment of erectile dysfunction. N Engl J Med 338:1397-1404 DOI |
12 | Gonzales GF, Cordova A, Vega K, Ghung A, Villena A, Gonez C, Castillo S. 2002. Effect of Lepidium meyenii (Maca) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. Andrologia 34:367-372 DOI |
13 | Lee HM, Park EJ, Jeon IS, Kang YS, Jin DI, Chung HJ. 2010. Effect of Maca supplementation on scopolamine-induced memory impairment of mice. Korean J Food & Nutr 23: 485-491 |
14 | Gonzales GF, Gasco M, Cordava A, Chung A, Rubio J, Villegas L. 2004. Effect of Lepidium meyenii (maca) on spermatogenesis in male rats acutely exposed to high altitude (4340 m). J Endocrinol 180:87-95 DOI |
15 | Ignarro LJ, Bush PA, Buga GM, Wood KS, Fukuto JM, Rajfer J. 1990. Nitric oxide and c-GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem Biophys Res Comm 170:843-850 DOI |
16 | Valentova K, Ulrichova J. 2003. Smallanthus sonchifolius and Lepidium meyenii - Prospective andean crops for the prevention of chronic diseases. Bimed 147:119-130 |
17 | Lincoln TM. 1989. Cyclic GMP and mechanism of vasodilation. Pharmcol Ther 41:479-502 DOI |
18 | Li J, Chen L, Li J, Duan Z, Zhu S, Fan L. 2017. The Composition analysis of Maca (Lepidium meyenii Walp.) from xinjiang and its antifatigue activity. J Food Qual 2017 |
19 | Milman N, Burton CM, Iversen M, Videbæk R, Jensen CV, Carlsen J. 2008. Pulmonary hypertension in end-stage pulmonary sarcoidosis: Therapeutic effect of sildenafil. J Heart Lung Transplant 27:329-334 DOI |
20 | Mcmahon CG, Samali R, Johnson H. 2000. Efficacy, safety and patient acceptance of sildenafil citrate as treatment for erectile dysfunction. J Urol 164:1192-1196 DOI |
21 | Rubio J, Riqueros MI, Gasco M, Yucra S, Miranda S, Gonzales GF. 2006. Lepidium meyenii (maca) reversed the lead acetate induced-damage on reproductive function in male rats. Food Chem Toxicol 44:1114-1122 DOI |
22 | Ha BJ, Nam CS, Park EK, Kang KS. 2006. The relevance of Salicornia herbacea and Epimedium koreanum to hepatotoxicity. J Nat Sci 15:50-60 |
23 | Tirapelli CR, Fukada SY, Yogi A, Chignalia AZ, Tostes RC, Bonaventura D, Lanchote VL, Cunha FQ, de Oliveira AM. 2008. Gender-specific vascular effects elicited by chronic ethanol consumption in rats: A role for inducible nitric oxide synthase. Br J Pharmacol 153:468-479 DOI |
24 | Woo YK, Kim TH, Koh JH. 2013. Variation patterns of the blood lipid levels on the Sprague-Dawley rats fed with Kochujang extracts. Korean J Food & Nutr 26:737-744 DOI |
25 | Zenico T, Cicero AFG, Valmorri L, Mercuriali M, Bercovich E. 2009. Subjective effects of Lepidium meyenii (Maca) extract on well-being and sexual performances in patients with mild erectile dysfunction: A randomised, double-blind clinical trial. Andrologia 41:95-99 DOI |
26 | Zheng BL, He K, Kim CH, Rogers L, Shao Y, Huang ZY, Lu Y, Yan SJ, Qien LC, Zheng QY. 2000. Effect of a lipidic extract from Lepidium meyenii on sexual behavior in mice and rats. Urology 55:598-602 DOI |
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