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http://dx.doi.org/10.9799/ksfan.2016.29.6.998

Anti-inflammatory Effect of Lactuca sativa L. Extract in Human Umbilical Vein Endothelial Cells and Improvement of Lipid Levels in Mice Fed a High-fat Diet  

Hwang-Bo, Jeon (Dept. of Genetic Engineering and Graduate School of Biotechnology, Kyung Hee University)
Jang, Kyung Ok (Dept. of Genetic Engineering and Graduate School of Biotechnology, Kyung Hee University)
Chung, Hayoung (Cosmogen Co. Ltd.)
Park, Jong-Hwa (Dept. of Genetic Engineering and Graduate School of Biotechnology, Kyung Hee University)
Lee, Tae Hoon (Graduate School of East-West Medicinal Science Kyung Hee University)
Kim, Jiyoung (Cosmogen Co. Ltd.)
Chung, In Sik (Dept. of Genetic Engineering and Graduate School of Biotechnology, Kyung Hee University)
Publication Information
The Korean Journal of Food And Nutrition / v.29, no.6, 2016 , pp. 998-1007 More about this Journal
Abstract
The objective of this study was to investigate the effects of a lettuce (Lactuca sativa L.) extract on the inflammation of human umbilical vein endothelial cell (HUVEC) and blood lipid improvement in hypercholesterolemic mice fed a high cholesterol diet. The lettuce extract (100% ethanol extract) inhibited the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in HUVEC treated with tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$). The lettuce extract suppressed the adhesion of THP-1 to TNF-${\alpha}$-treated HUVEC. The lettuce extract decreased the TNF-${\alpha}$-stimulated production of proinflammatory cytokine interleukin-6, interleukin-8 and chemokine monocyte chemotactic protein 1. In hypercholesterolemic mice, the lettuce extract reduced serum total cholesterol, triglyceride, and low-density lipoprotein-cholesterol level, while the lettuce extract elevated high-density lipoprotein-cholesterol level, resulting in the decrease of atherogenic index and cardiac risk factor level. These results suggested that lettuce extract can be an useful resource to show an anti-inflammatory effect and improve lipid metabolism.
Keywords
lettuce extract; inflammation; hypercholesterolemia; lipid metabolism;
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Times Cited By KSCI : 5  (Citation Analysis)
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