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http://dx.doi.org/10.9799/ksfan.2015.28.4.579

Rutin Suppresses Neoplastic Cell Transformation by Inhibiting ERK and JNK Signaling Pathways  

Kang, Nam Joo (School of Food Science and Biotechnology, Kyungpook National University)
Publication Information
The Korean Journal of Food And Nutrition / v.28, no.4, 2015 , pp. 579-585 More about this Journal
Abstract
Rutin is a well-known flavonoid found in buckwheat. Recent studies have demonstrated that the biological actions of rutin include anti-inflammatory and anti-cancer effects, but the underlying molecular mechanisms of these actions are not yet fully understood. Neoplastic cell transformation is considered a major event that contributes to carcinogenesis, and the present study aimed to determine whether rutin would exert anti-tumor effects via the results suggest that rutin exerted a potent inhibitory influence on the molecular activity of the MEK/ERK and MKK4/JNK pathways and strongly attenuated EGF-induced neoplastic cell transformation. These findings provide insight into the biological actions of rutin and the molecular basis for the development of new chemoprotective agents.
Keywords
rutin; ERK; JNK;
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