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http://dx.doi.org/10.9799/ksfan.2015.28.4.551

Anti-inflammatory Activities of Methanolic Extracts from Different Rose Cultivars  

Lee, Seon-Mi (Dept. of Food Science and Biotechnology, Chungbuk National University)
Li, Lin (Dept. of Food Science and Biotechnology, Chungbuk National University)
Sung, Jeehye (Dept. of Food Science and Biotechnology, Chungbuk National University)
Yang, Jinwoo (Dept. of Food Science and Biotechnology, Chungbuk National University)
Kim, Younghwa (School of Food Biotechnology and Nutrition, Kyungsung University)
Jeong, Heon Sang (Dept. of Food Science and Biotechnology, Chungbuk National University)
Lee, Junsoo (Dept. of Food Science and Biotechnology, Chungbuk National University)
Publication Information
The Korean Journal of Food And Nutrition / v.28, no.4, 2015 , pp. 551-557 More about this Journal
Abstract
The genus Rosa (Rosaceae) is an abundant source of phenolics and is traditionally used as a food supplement and as herbal medicine. Various plant phenolics are known to have anticancer, antioxidant, and anti-inflammatory properties. In this study, we investigated the anti-inflammatory effects of rose methanolic extracts (RMEs) from four different rose cultivars (Macarena, Onnuri, Oklahoma, and Colorado) in lipopolysaccharide (LPS)-activated RAW 264.7 cells. Our results demonstrated that pretreatment of REMs ($500{\mu}g/mL$) significantly reduced NO production by suppressing iNOS protein expression in LPS-stimulated cells. Anti-inflammatory effects by RMEs were observed in the following order: Oklahoma > Colorado > Onnuri > Macarena. Consistent with this finding, RMEs inhibited the translocation of $NF-{\kappa}B$ from the cytosol to the nucleus via the suppression of $I{\kappa}B{\alpha}$ phosphorylation and also inhibited LPS-stimulated $NF-{\kappa}B$ transcriptional activity. These findings suggest that RMEs exert anti-inflammatory actions and help to elucidate the mechanisms underlying the potential therapeutic values of RMEs. Therefore, RMEs could be regarded as a potential source of natural anti-inflammatory agents.
Keywords
rose petal; anti-inflammation; nitric oxide; $NF-{\kappa}B$;
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