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http://dx.doi.org/10.9799/ksfan.2013.26.4.909

Study on the Correlation between the Nutrient Intakes and Clinical Indices of Type 2 Diabetes Patients  

Kwon, Ji-Young (Graduate School of Human Environmental Sciences, Yonsei University)
Chung, Hae-Yun (Dept. of Food and Nutrition, Soongeui Women's College)
Publication Information
The Korean Journal of Food And Nutrition / v.26, no.4, 2013 , pp. 909-918 More about this Journal
Abstract
The objective of this study is to investigate the effects of dietary nutrient intakes for markers of blood glucose and inflammation which is important to the progress of type 2 diabetes and the development of its complications. For this study, 76 adults with diabetes (42 males, 34 females) were recruited from a group of patients who had visited the department of endocrine medicine. Data on anthropometric characteristics, clinical indices such as hemoglobin A1c (HbA1c) and C-reactive protein (CRP), and dietary nutrient intakes were collected. Our results have shown that 66% of subjects were either overweight or obese. Serum analysis indicates that levels of C-peptide, glucose, HbA1c, CRP, triglyceride, LDL-cholesterol were higher than normal range. Results from the dietary nutrient intake survey displayed that intakes of cholesterol and sodium were higher than Dietary Reference Intakes for Koreans. On the contrary, folate intake was lower than the guideline. Within the females, energy contribution from carbohydrate was higher than Korean Diabetes Association guideline. Statistical analysis has revealed a negative correlation between serum HbA1c level and dietary intakes of polyunsaturated fatty acid (PUFA), n-3 PUFA, ${\beta}$-carotene and vitamin E after adjustments for age, BMI, smoking habits, alcohol consumption, exercise and ingestion of diabetes mellitus medication (p<0.05). Serum CRP level was inversely associated with dietary intakes of carbohydrate, protein, vitamin C and fiber (p<0.05). Our results suggest that dietary nutrient intakes may influence the levels of HbA1c and CRP, and subsequently, it may help in the management/treatment of type 2 diabetes.
Keywords
type 2 diabetes; hemoglobin A1c; C-reactive protein; dietary nutrient intake;
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1 Agrawal A, Cha-Molstad H, Samols D, Kushner I. 2001. Trans activation of C-reactive protein by IL-6 requires synergistic interaction of CCAAT/enhancer binding protein beta (C/EBP beta) and Rel p50. J Immunol 166:2378-2384   DOI
2 American Diabetes Association. 2003. Standards of medical care for patients with diabetes mellitus. Diabetes Care 26:33-50   DOI
3 Arnlov J, Zethelius B, Riserus U, Basu S, Berne C, Vessby B, Alfthan G, Helmersson J. 2008. Serum and dietary betacarotene and alpha-tocopherol and incidence of type 2 diabetes mellitus in a community-based study of Swedish men: report from the Uppsala Longitudinal Study of Adult Men (ULSAM) study. Diabetologia 52:97-105
4 Asegaonkar SB, Marathe A, Tekade ML, Cherekar L, Bavikar J, Bardapurkar J, Ajay R. 2011. High-sensitivity C-reactive protein: a novel cardiovascular risk predictor in type 2 diabetics with normal lipid profile. J Diabetes Complications 25:368-370   DOI   ScienceOn
5 Block G, Jensen CD, Dalvi TB, Norkus EP, Hudes M, Crawford PB, Holland N, Fung EB, Schumacher L, Harmatz P. 2009. Vitamin C treatment reduces elevated C-reactive protein. Free Radic Biol Med 46:70-77   DOI   ScienceOn
6 Ceriello A, Testa R. 2009. Antioxidant anti-inflammatory treatment in type 2 diabetes. Diabetes Care 32:S232-S236   DOI   ScienceOn
7 Cheung N, Mitchell P, Wong TY. 2010. Diabetic retinopathy. Lancet 376:124-136   DOI   ScienceOn
8 Chun OK, Chung SJ, Claycombe KJ, Song WO. 2008. Serum C-reactive protein concentrations are inversely associated with dietary flavonoid intake in U.S. adults. J Nutr 138:753-760   DOI
9 Chung JH, Kim OS. 2005. Alcohol consumption and cigarette smoking in men with diabetes mellitus. Korean J Adult Nurs 17:68-76
10 Cosentino F, Eto M, Paolis PD, van der Loo B, Bachschmid M, Ullrich V, Kouroedov A, Gatti CD, Joch H, Volpe M, Luscher TF. 2003. High glucose causes upregulation of cyclooxygenase-2 and alters prostanoid profile in human endothelial cells. Circulation 107:1017-1023   DOI   ScienceOn
11 Ebbeling CB, Swain JF, Feldman HA, Wong WW, Hachey DL, Garcia-Lago E, Ludwig DS. 2012. Effects of dietary composition on energy expenditure during weight-loss maintenance. JAMA 307:2627-2634
12 Erion DM, Shulman GI. 2010. Diacylglycerol-mediated insulin resistance. Nat Med 16:400-402   DOI   ScienceOn
13 Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. 2003. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 26:S5-S20   DOI
14 Fang F, Kang Z, Wong C. 2010. Vitamin E tocotrienols improve insulin sensitivity through activating peroxisome proliferatoractivated receptors. Mol Nutr Food Res 54:345-352   DOI   ScienceOn
15 Fedor D, Kelley DS. 2009. Prevention of insulin resistance by n-3 polyunsaturated fatty acids. Curr Opin Clin Nutr Metab Care 12:138-146   DOI   ScienceOn
16 Franz MJ, Bantle JP, Beebe CA, Brunzell JD, Chiasson JL, Garg A, Holzmeister LA, Hoogwerf B, Mayer-Davis E, Mooradian AD, Purnell JQ, Wheeler M. 2002. Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications. Diabetes Care 25:148-198   DOI   ScienceOn
17 Gulliford MC, Ukoumunne OC. 2001. Determinants of glycated haemoglobin in the general population: Associations with diet, alcohol and cigarette smoking. Eur J Clin Nutr 55:615-623   DOI
18 Garcia-Mediavilla V, Crespo I, Collado PS, Esteller A, Sanchez-Campos S, Tunon MJ, Gonzalez-Gallego J. 2007. The antiinflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells. Eur J Pharmacol 557:221-229   DOI   ScienceOn
19 Genest J. 2010. C-reactive protein: risk factor, biomarker and/or therapeutic target? Can J Cardiol 26:41A-44A   DOI   ScienceOn
20 Giacco F, Brownlee M. 2010. Oxidative stress and diabetic complications. Circ Res 107:1058-1070   DOI   ScienceOn
21 Haimoto H, Iwata M, Wakai K, Umegaki H. 2008. Long-term effects of a diet loosely restricting carbohydrates on HbA1c levels, BMI and tapering of sulfonylureas in type 2 diabetes: a 2-year follow-up study. Diabetes Res Clin Pract 79:350-356   DOI   ScienceOn
22 Huffman KM, Orenduff MC, Samsa GP, Houmard JA, Kraus WE, Bales CW. 2007. Dietary carbohydrate intake and highsensitivity C-reactive protein in at-risk women and men. Am Heart J 154:962-968   DOI   ScienceOn
23 Hunt JV, Smith CC, Wolff SP. 1990. Autoxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose. Diabetes 39:1420-1424   DOI
24 Julia C, Touvier M, Meunier N, Papet I, Galan P, Hercberg S, Kesse-Guyot E. 2013. Intakes of PUFAs were inversely associated with plasma C-reactive protein 12 years later in a middle-aged population with vitamin E as an effect modifier. J Nutr 143:1760-1766   DOI   ScienceOn
25 Krishnamurti U, Steffes MW. 2001. Glycohemoglobin: a primary predictor of the development or reversal of complications of diabetes mellitus. Clin Chem 47:1157-1165
26 King DE, Mainous AG 3rd, Egan BM, Woolson RF, Geesey ME. 2005. Fiber and C-reactive protein in diabetes, hypertension, and obesity. Diabetes Care 28:1487-1489   DOI   ScienceOn
27 Kodama S, Saito K, Tanaka S, Maki M, Yachi Y, Sato M, Sugawara A, Totsuka K, Shimano H, Ohashi Y, Yamada N, Sone H. 2009. Influence of fat and carbohydrate proportions on the metabolic profile in patients with type 2 diabetes: a meta-analysis. Diabetes Care 32:959-965   DOI   ScienceOn
28 Korean Diabetes Association. 2011. Treatment Guideline for Diabetes. 4th ed. pp.52-57. Korean Diabetes Association
29 Lastra G, Dhuper S, Johnson MS, Sowers JR. 2010. Salt, aldosterone, and insulin resistance: impact on the cardiovascular system. Nat Rev Cardiol 7:577-584   DOI
30 Lee JE, Park HA, Kang JH, Lee SH, Cho YG, Song HR, Kim SW, Lee JS. 2008. State of diabetes care in Korean adults -According to the American Diabetes Association Recommendations-. J Korean Acad Fam Med 29:658-667   과학기술학회마을
31 Lee JG, Lee SY, Min HG, Kim YJ, Choi SH, Kim YJ. 2004. The correlation between vitamin C intake and plasma highsensitive C-reactive protein concentration. J Korean Acad Fam Med 25:314-321
32 Lee JH. 2002. An assessment on food habits and nutritional status of diabetics. MS Thesis, Yonsei Uni. Seoul. Korea
33 National Cholesterol Education Program (NCEP). 2002. Third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation 106:3143-3421
34 Mahon AK, Flynn MG, Stewart LK, McFarlin BK, Iglay HB, Mattes RD, Lyle RM, Considine RV, Campbell WW. 2007. Protein intake during energy restriction: Effects on body composition and markers of metabolic and cardiovascular health in postmenopausal women. J Am Coll Nutr 26:182-189   DOI
35 McGarry JD. 1992. What if minkowski had been ageusic? An alternative angle on diabetes. Science 258:766-770   DOI
36 Ministry of Health and Welfare. 2011. 2010 The Fifth Korea National Health and Nutrition Examination Survey (KNHANES V)
37 Pansuria M, Xi H, Li L, Yang XF, Wang H. 2012. Insulin resistance, metabolic stress, and atherosclerosis. Front Biosci (Schol Ed) 4:916-931
38 Patel N, Taveira TH, Choudhary G, Whitlatch H, Wu WC. 2012. Fasting serum C-peptide levels predict cardiovascular and overall death in nondiabetic adults. J Am Heart Assoc 1: e003152
39 Peuchant E, Brun JL, Rigalleau V, Dubourg L, Thomas MJ, Daniel JY, Leng JJ, Gin H. 2004. Oxidative and antioxidative status in pregnant women with either gestational or type 1 diabetes. Clin Biochem 37:293-298   DOI   ScienceOn
40 Rizzo MR, Abbatecola AM, Barbieri M, Vietri MT, Cioffi M, Grella R, Molinari A, Forsey R, Powell J, Paolisso G. 2008. Evidence for anti-inflammatory effects of combined administration of vitamin E and C in older persons with impaired fasting glucose: impact on insulin action. J Am Coll Nutr 27:505-511   DOI
41 Sluijs I, Beulens JW, van der A DL, Spijkerman AM, Grobbee DE, van der Schouw YT. 2010. Dietary intake of total, animal, and vegetable protein and risk of type 2 diabetes in the European prospective investigation into cancer and nutrition (EPIC)-NL study. Diabetes Care 33:43-48   DOI   ScienceOn
42 Santos S, Oliveira A, Casal S, Lopes C. 2013. Saturated fatty acids intake in relation to C-reactive protein, adiponectin, and leptin: a population-based study. Nutrition 29:892-897   DOI   ScienceOn
43 Sikaris K. 2009. The correlation of hemoglobin A1c to blood glucose. J Diabetes Sci Technol 3:429-438   DOI   ScienceOn
44 Silva JP, Coutinho OP. 2010. Free radicals in the regulation of damage and cell death - basic mechanisms and prevention. Drug Discov Ther 4:144-167
45 Stratton IM, Adler AI, Neil HAW, Matthews DR, Manley SE, Cull CA, Hadden D, Turner RC, Holman RR. 2000. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study. BMJ 321:405-412   DOI   ScienceOn
46 Summers SA. 2006. Ceramides in insulin resistance and lipotoxicity. Prog Lipid Res 45:42-72   DOI   ScienceOn
47 Task Force Team for Basic Statistical Study of Korean Diabetes Mellitus of Korean Diabetes Association. 2013. Diabetes epidemics in Korea: Reappraise nationwide survey of diabetes "Diabetes in Korea 2007". Diabetes Metab J 37:233-239   DOI   ScienceOn
48 Upritchard JE, Sutherland WH, Mann JI. 2000. Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes. Diabetes Care 23:733-738   DOI   ScienceOn
49 Williams KV, Mullen ML, Kelley DE, Wing RR. 1998. The effect of short periods of caloric restriction on weight loss and glycemic control in type 2 diabetes. Diabetes Care 21:2-8   DOI   ScienceOn
50 van Woudenbergh GJ, Kuijsten A, Tigcheler B, Sijbrands EJ, van Rooij FJ, Hofman A, Witteman JC, Feskens EJ. 2012. Meat consumption and its association with C-reactive protein and incident type 2 diabetes: the Rotterdam Study. Diabetes Care 35:1499-1505   DOI
51 Yusuf S, Dagenais G, Pogue J, Bosch J, Sleight P. 2000. Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Eng J Med 342:154-160   DOI   ScienceOn