Browse > Article
http://dx.doi.org/10.9799/ksfan.2012.25.4.897

Biological Activities of Solvent Fractions from Methanolic Extract of Crataegi fructus  

Park, Sung Jin (Dept. of Tourism Food Service Cuisine, Hallym College)
Shin, Eon Hwan (Dept. of Hotel Culinary Arts & Nutrition, Ulsan College)
Lee, Jae Ha (Shinsegae SVN R&D)
Publication Information
The Korean Journal of Food And Nutrition / v.25, no.4, 2012 , pp. 897-902 More about this Journal
Abstract
The purpose of this study is to determine the possibility of using Crataegi fructus as natural health food source. The research was conducted to determine the biofunctional activities of Crataegi fructus extract. Methanolic extract from Crataegi fructus was partitioned by using organic solvents, including n-hexane, ethyl acetate, n-butanol, and water. Ethyl acetate soluble fraction was shown to have the strongest antioxidant activity ($RC_{50}=4.39{\mu}g/m{\ell}$) among the fractions. In the antimicrobial activity assays, ethyl acetate soluble fraction was effective in bacterial inhibition, against the cases of Escherichia coli and Klebsiella pneumonia, with minimum inhibitory concentrations in $125{\mu}g/m{\ell}$. In the anticomplementary activity assays, water soluble fraction was the most effective exhibiting 18.4% inhibitory activity.
Keywords
Crataegi fructus; anticomplement activity; DPPH free radical scavenging activity;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Ames BN, Saul RL. 1987. Oxidative DNA damage, cancer and aging. Oxygen and human disease. Am Inter Med 107:536- 539
2 Branen AL. 1975. Toxicology and biochemistry of butylated hydroxy anisol and butylated hydroxytoluene. J Am Oil Chem Soc 52:59-63   DOI
3 Choe SY, Yang KH. 1982. Toxicological studies of antioxidants butylated hydroxytoluene (BHT) and butylated hydroxy anisol (BHA). Korean J Food Sci Technol 14:283-288
4 Choi JS, Park JH, Kim HG, Young HS, Mun SI. 1993. Screening for antioxidant activity of plants and marine algae and its active principles from Prunus daviana. Kor J Pharmacol 24:299-303
5 Chu CY, Lee MJ, Liao CL, Lin WL, Yin TF, Tseng TH. 2003. Inhibitory effect of hot-water extract from dried fruit if Crataegus pinnatifida on low-density lipoprotein (LDL) oxidation in cell and cell-free system. J Agr Food Chem 51:7583-7588   DOI   ScienceOn
6 Fumijo N, Keiichi G, Ryota S, Masayuki S, Miwa S, Yukihiko H. 1996. Scavenging effects of tea catechins and their derivatives on 1,1-diphenyl-2-picrylhydrazyl radical. Free Rad Biol Med 21:895-902   DOI   ScienceOn
7 Han SS, Lo SC, Choi YH, Kim MJ, Kwak SS. 1999. Antioxidative compounds in extracts of Acer ginnala Max. Korean J Med Crop Sci 7:51-57   과학기술학회마을
8 Klerx JP, Benkelman CJ, Van DH, Willers JM. 1983. Microassay for colorimetric estimation of complement activity in guinea pig, human and mouse serum. J Immunol Meth 63:215-220   DOI   ScienceOn
9 Kobayashi A, Kim MJ, Kawaz K. 1996. Uptake and exudation of phenolic compounds by wheat and antimicrobial components of the root exudate. Z Naturforsch 51:527-533
10 Kwon HJ, Hyun SH, Choung SY. 2005. Traditional Cheness medicine improves dysfunction of peroxisome proliferatoractivated receptor alpha and microsomal triglyceride transfer protein on abnormalities in lipid metabolism in ethanol-fed rats. Biofactors 23:163-176   DOI
11 Shahidi F, Wanasundara PKJPD. 1992. Phenolic antioxidants. Crit Rev Food Sci Nutr 32:67-103   DOI   ScienceOn
12 Min BS, Huong HT, Kim JHm Jun HJ, Na MK, Nam NH, Lee HK, Bae K, Kanf SS. 2004. Furo-1,2-naphthoquinones from Crataegus pinnatifida with ICAM-1 expression inhibition activity. Planta Med 70:1166-1169   DOI   ScienceOn
13 Pratt DE, Huang MT, Ho ST, Lee CY. 1992. In phenolic compounds in food and their effects on health (II), Antioxidants and Cancer Prevention. Washington D.C. pp. 54-71
14 Rhaman MM, Alexander IG. 2002. Antimicrobial constituents from the stem bark of Feronia limonia. Phytochem 59:73-77   DOI   ScienceOn
15 한국약학대학협의회 약전분과회. 1981. 대한약전, 문성사, p. 790
16 Song JC, Park NK, Hur HS, Bang MH, Baek NI. 2000. Examination and isolation of natural antioxidants from Korean medicinal plants. Korean J Med Crop Sci 8:98-102   과학기술학회마을
17 Xiong Q, Kadota S, Tadata T, Namba T. 1996. Antioxidative effects of phenylethanoids from Cistanche deserticola. Biol Pharmaceuti Bull 19:1580-1585   DOI   ScienceOn
18 Yamada H, Yanahira S, Kiyhara H, Yon JC, Otsuka Y. 1989. Water-soluble glucans from the seed of Coix laorymajobi var. ma-yuen. Phytochem 25:129-132
19 Kessler M, Ubeaud G, Jung L. 2003. Anti- and pro-oxidant activity of rutin and quercetin derivatives. J Pharm Pharmacol 55: 131-142   DOI   ScienceOn
20 Inatani R, Nakatani N, Fuwa H. 1983. Antioxidative effect of the constituents of rosemary (Rosmarinus officinalis L.) and their derivatives. Agr Biol Chem 47:521-528   DOI
21 Kim JS, Lee KD, Kwon JH, Yoon HS. 1993. Antioxidative effectivencess of ether extract in Crataegus pinnatifida Bunge and Terminalia chebula rets. J Korean Agr Chem Soc 36:203-207
22 Kim MJ, Hyun JO. 1997. Genetic variation in urushiol components of Rhus verniciflua Stokes. Kor J Breed 29:115-123
23 Kim YY, Koo Sj. 1997. Anticomplementary activity and immunestimulating effect of the extracts from barley (Hordeum vulgare). Korean J Food Sci Technol 13:661-668