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http://dx.doi.org/10.9799/ksfan.2012.25.4.800

Inhibitory Effects of Panax ginseng C. A. Mayer Treated with High Temperature and High Pressure on Oxidative Stress  

Yoon, Bo-Ra (Korea Food Research Institute)
Lee, Young-Jun (Dept. of Food Science and Biotechnology, Kangwon National University)
Hong, Hee-Do (Korea Food Research Institute)
Lee, Young-Chul (Korea Food Research Institute)
Kim, Young-Chan (Korea Food Research Institute)
Rhee, Young Kyoung (Korea Food Research Institute)
Kim, Kyung-Tack (Korea Food Research Institute)
Lee, Ok-Hwan (Dept. of Food Science and Biotechnology, Kangwon National University)
Publication Information
The Korean Journal of Food And Nutrition / v.25, no.4, 2012 , pp. 800-806 More about this Journal
Abstract
Reactive oxygen species (ROS) are produced by oxidative stresses which cause various chronic diseases such as diabetes and obesity. Ginseng (Panax ginseng C.A. Mayer) has been reported to contain various biological activities such as anti-cancer, anti-diabetic, neuroprotective, radioprotective, anti-amnestic and anti-aging effects. In this study, we investigated the effects of Panax ginseng, treated with high temperatures and high pressures, on oxidative stress in C2C12 myoblasts and 3T3-L1 adipocytes. Oxidative stress was induced in the C2C12 cells through the introduction of $H_2O_2$ (1 mM), and cells were then treated with various ginseng preparations: dried white ginseng (DG), steamed ginseng (SG) and high temperature and high pressure treated ginseng (HG). In addition, 3T3-L1 preadipocytes were treated with various ginsengs for up to 8 days following standard induction of differentiation. Our results show that HG treatment significantly protected oxidative stress in both cell lines and enhanced gene expression of antioxidant enzymes. Therefore, in this study, we investigated the protective effects of ginseng on the oxidative stress of adipocytes and muscle cells.
Keywords
3T3-L1 adipocyte; C2C12 myoblast; Panax ginseng; oxidative stress; antioxidant;
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Times Cited By KSCI : 15  (Citation Analysis)
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