Browse > Article
http://dx.doi.org/10.9799/ksfan.2011.24.1.028

Biochemical Study on the Effects of the Omija(Schizandra chinensis Baillon) Extracts in Rat Kidney Toxicity Induced by Aluminum  

Jung, Young-Hee (Dept. of Food and Nutrition, Kwangju Health Science University)
Han, Sung-Hee (Dept. of Food and Nutrition, Wonkwang Health Science University)
Publication Information
The Korean Journal of Food And Nutrition / v.24, no.1, 2011 , pp. 28-36 More about this Journal
Abstract
To investigate the protective effect of omija(Schizandra chinensis Baillon) tea extracts against the aluminum toxicity, Sprague-Dawley rats($100{\pm}10\;g$) were divided into 6 groups consisting of a control group, a 3% Schizandra chinensis Baillon tea plus extract group, a 1,000 and 2,000 ppm aluminum group, and a 1,000 and 2,000 ppm aluminum plus 3% Schizandra chinensis Baillon tea plus extract group. The rats administered aluminum were given 1,000 and 2,000 ppm of $Al_2(SO_4)_3$ dissolved in distilled water. The aluminum content in tissues from rats administered aluminum was lower than in the tissues of rats of administered aluminum plus 3% Schizandra chinensis Baillon tea in the water extract. Aspartate aminotransferase (AST) and alanine aminotransferase(ALT) levels were increased in the aluminum group and lower in the group receiving a 3% extract of Schizandra chinensis Baillon tea. Lactate dehydrogenase(LDHase) was lower in the group receiving a 3% extract of Schizandra chinensis Baillon tea plus aluminum than in the aluminum group. Cholinesterase(ChEase) was higher in the 3% Schizandra chinensis Baillon tea-aluminum group than in the aluminum group. Plasma levels of renin were increased in the aluminum group, compared to the group receiving 3% Schizandra chinensis Baillon tea plus aluminum. Plasma levels of aldosterone were increased in the aluminum group compared with the 3% Schizandra chinensis Baillon tea plus aluminum group. These results suggest that the group receiving Schizandra chinensis Baillon tea in water extract had a lowered level of aluminum accumulation, and it is believed that the Schizandra chinensis Baillon tea plus water had some protective effects against aluminum toxicity when administered in rats, but the mechanism of these effects remains obscure.
Keywords
Schizandra chinensis Baillon tea extract group; aluminum; AST; ALT; LDH; ChEase; renin; aldosterone;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Han SH, Shin MK. 2005. Effects of water in extracts of Pueraria radix on serum enzymes activities in aluminum-administerates. J Korean Soc Food Culture 20:113-122
2 Huang KC. 1993. The Pharmacomology of Chineses Herbs. pp.201-203. CRC Press. Florida
3 Ichikawa H, Wang L, Konish T. 2006. Prevention of cerebral oxidative injury by post-ischemic intravenous administration of Shengmai San. Am J Chin Med 34:591-600   DOI   ScienceOn
4 El-Maraghy SA, Gad MZ, Fahim AT, Hamdy MA. 2001. Effects of cadmium and aluminum intake in the antioxidant state and lipid peroxidation in rat tissues. J Biochem Molecular Toxicology 15:207-214   DOI   ScienceOn
5 Ganje JJ, Page AL. 1976. Rapid acid dissoulation of plant tissue for cadium determination by atomic absorption spectrophotometry. At Absorpt Newsl 131:108-110
6 Ginsberg AL. 1970. Very high levels of SGOT and LDH in patients with extrahepatic billiary tract obstruction. J Amer Dig Dis 15:803-805   DOI   ScienceOn
7 Chung KA, Roh YB. 2000. Histoligical study on the effects of the green-tea in rats kidney toxicated by lead. Korean J Electron Microscophy 30:273-283
8 Goodfriend TL, Levine L, Fasma GD. 1964. Antibodies to bradykinin and angiotensin. A use of carbodiimide in immunololgy. Science 144:1344-1346   DOI   ScienceOn
9 Cho KW, Kim SH, Koh GY, Seul KH, Huh KS, Chu D, Rap NS, Moon HB, Kim KK, Kook YJ. 1989. Plasma concentration of atrial natriuretic peptide in different phase of Korean hemmorrhagic fever. Nephron 51:215-219   DOI
10 Choi BS, Park YJ, Kweon IH, Hong YP, Park JD. 2002. Reference values of mercury in liver and kidney of Korean. Korean J Environ Toxicol 17:119-115   DOI   ScienceOn
11 Deloncle R, Huguet F, Babin P, Fermandez B, Quellard N, Guillard O. 1999. Chronic administration of aluminum Lglutamate in young mature rats, effects in iron levels and lipid peroxidation in selectred brain areas. Toxicology Letters 10:65-73
12 Candy JM, Oakley AE, Klinowski J, Carpenter TA, Perry RH, Attack JR, Perry EK, Blessed G, Fairbrain A, Edwawdson JA. 1986. Aluminosilicates and sensile plague formation in Alzherimer's disease. Lancet 327(8477):354-356   DOI   ScienceOn
13 Brenner BM, Rector FC. 1981. The Kidney. pp.371-399, 650-679, 723, 741. Saunders
14 Berlyne, NC, Yagil. R, Ben Ari J, Weinberger G, Knopf E, Danovith GM. 1972. Aluminum toxicity in rats. Lancet 299:546-567
15 Bowen DM, Benren JS, Allen SJ, Good Hardt MJ. 1983. Biochemical assessment of serotonergic and cholinergic dysfunction and cerebral atrophy in Alzherimer's disease. J Neurochem 41:266-272   DOI   ScienceOn
16 Cho KW, Malvin RL. 1979. Renin inactivation during in vitro. Experimental Am J Physiol 236:501-504
17 Armstrong RA, Winsper SJ, Blair JA. 1999. Aluminum and Alzherimer's disease review of possible payhogenic mechanisms. Dementia 7:1-9
18 Cho KW, Kim SH. 1982. Factors affecting the relationship between renal renin activity and plasma renin activity. Kor J Physiol 16:63-69
19 Cho KW, Kim SH, Koch GY. 1987. Radioimmunoassay and characterization of renin-angiotensin system in the fresh water turtle. J Exp Zool 242:255-262   DOI
20 Amador E, Dorfman E, Wacker WE. 1963. Serum lactic dehydrogenase activity an analytical assessment of current assays. Clin Chem 8:391-399
21 Michael HH, Smith JL. 1981. Effects of vitamin D and low dietary calcium on lead uptake and retention in rats. J Nutr 111:694-701
22 Aksari P, Stoppe G. 1996. Risk factors in Alzheimer's dementia. Fortschritteder Neurologie-psychiartrie 64:425-432   DOI   ScienceOn
23 Bergmeyer HU. 1995. Verlag chemic academic press weinheim. Methods of Enzymatic Analysis 6:20-28
24 Sedman AB, Wikening GN, Bradely PD, Warady BA, Lum GM, Alfrey AC. 1984. Encephalopathy in childhood secondary to aluminum toxicity. Journal of Pediatrics 105:835-836
25 Sealey JE, Laragh JH. 1973. Searching out low renin patients limitation of some commonly used methods. Am J Med 55:303-314   DOI   ScienceOn
26 Tang W, Eisenbrand G. 1992. Chinese Drugs of Plant Origin. pp.903-912. Springen-Verlag, Berlin
27 Wroblewski F, LaDue JS. 1955. Lactic dehydrogenase activity in blood. Proc Soc Exper Biol Med 90:210-213   DOI
28 Zhu M, Lin KF, Yeung RY, Li RC. 1999. Evaluation of the protective effects of Scizandra chinensis on phase I drug metabolism using a $CCl_{4}$ intoxication model. J Ethnopharmacol 67:61-68   DOI   ScienceOn
29 Nomura M, Nakachiyama M, Hida T, Ohtaki Y, Sudo K, Aizawa T, Aburada M, Miyamoto KI. 1994. Gomisin A, a lignan component of Schizandra fruits, inhibits development of preneoplastic lesions in rat liver by 3'-methyl 1,4-dimethylaminoazobenzene. Cancer Lett 76:11-18   DOI   ScienceOn
30 Nishiyama N, Chu PJ, Saito H. 1996. A herbal prescription, S113, consiting and schizandra, improves learnung performance in senescence accelerated mouse. Biol Pharm Bull 19:388-393   DOI   ScienceOn
31 Neill D, Leake A, Hunghes D, Keith AB, Taylor GA, Allsop D, Rima BK, Morris C, Candy JM, Edwardson JA. 1996. Effect of aluminum on expression and processing of amyloid precursor protein. J of Neuroscience Reserach 46:395-403   DOI   ScienceOn
32 Rhee SJ, Kim SO, Choe WK, Cho SH. 1992. Effect of cadium dose injection on peroxidative damage in rat river. J Korean Soc Food Nutr 21:601-607
33 Ock ES. 1995. Effect of Schizandra chinensis extract in hyperlipidemic rats. J Korean Soc Food Nutr 24:658-662
34 Reitman S, Frankel S. 1957. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Amer J Clin Pathol 28:56-60   DOI
35 Rhee SJ, Hung PC. 1989. Metallothionein accumulation in CHO of cells in response to lead treatment. Chem Biol Interations 72:347-361   DOI   ScienceOn
36 Salib E Hillier V. 1996. A case-control study of Alzherimer's disease and aluminum occupation. Brith J Psychiatry 168:244-249   DOI   ScienceOn
37 Shoe HJ, Lee MY, Hwang GS. 1987. The effect of Schizandra fructus extract on blood constituents of alloxan-induced-diabetic rabbits. J Korean Soc Food Nutr 16:262-267
38 Kim OC, Jang HJ, 1994. Volatile components of Schizandra chinensis Bullion. Agric Chem Biotechnol 37:30-36
39 Ko KM, Lam BY. 2002. Schisandrin B protects against tertbutylhydroperoxide induced cerebral toxicity by enhancing glutathione antioxidant status in mouse brain. Mol Cell Biochem 238:181-186   DOI   ScienceOn
40 Kim SR, Lee MK, Koo KA, Kim SH, Sung SH, Lee NG, Markelonis GJ, Oh TH, Yang JH, Kim YC. 2004. Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity. J Neurosci Res 76:397-405   DOI   ScienceOn
41 Lansberg JP, McDonald B, Watt F. 1992. Absence of aluminum in neurotoc plague cores in Alzherimer's disease. Nature 360:65-68   DOI   ScienceOn
42 Lee HS. 1992. Analysis of aluminum concentration in serum and phospholipid composition and catecholamin concentration in the brain of rats feed aluminum in drinking water. Dept of Food, Sookmyung Uni. Korea
43 Lee JS, Lee SW. 1990. Effect of water extract in fruit of Omija (Schizandra chinensis Baillon) on alcohol metabolism. Korean J Dietary Culture 5:259-262
44 Long ZZ, Xie SS. 1979. Experimenal study on the enhancement of the immunosuppresive effect of cortisone by wurenchun, an extract of Schizandra chinensis Baillon isolation and structure determination of five new lignans A, B C, F and G and the absolute structure of schzandrin. Chem Pharmacol Bull 27:1383-1394   DOI   ScienceOn
45 Marquis, Black. 1984. Aluminum activation and inactivation of bovine caudate acetylcholinerserase. Bull Environ Contam Toxicol. 32:704-710   DOI   ScienceOn
46 Jeffery EH, Abreo K, Burgess E, Cannata J, Greger LJ. 1996. Systemic aluminum toxicity; effects on bone, hematopoietic tissue, and kidney. J Toxicology Environmental Health 48:649-665   DOI   ScienceOn
47 Kirschbaum BB, Werth AC. 1989. Acute aluminum toxocity associated with oral citrate and aluminum-containg antacids. American Journal of Medical Sciences 297:9-11   DOI   ScienceOn
48 Karmen A. 1955. A note on the spectrophotometer assay of glutamic oxaloacetic transaminase in human blood serum. J Clinic Invest 95:131-139
49 Kim JH, Park SD, Choi SY, Seong JH, Hoon KD. 2002. Preparation and antioxidant activity of health drink with extract powder from Carthamus tinctiorius L. seed. Korean J Food Sci Technol 5:108-182