Browse > Article

Improvements Caused by Silk Sericin Extract Derived from Silkworm in Blood Glucose and Lipid Concentration in Diabetic Rats  

Kim, Han-Soo (Dept. of Food Science & Technology, Pusan National University)
Seong, Jong-Hwan (Dept. of Food Science & Technology, Pusan National University)
Lee, Young-Guen (Dept. of Food Science & Technology, Pusan National University)
Xie, Cheng-Liang (Dept. of Food Science & Technology, Pusan National University)
Shin, Ji-Moon (Dept. of Food Science & Technology, Pusan National University)
Yoon, Ho-Dong (Food & Safety Research Division, National Fisheries Research & Development Institute)
Publication Information
The Korean Journal of Food And Nutrition / v.23, no.3, 2010 , pp. 392-398 More about this Journal
Abstract
The objective of this study was to assess improvements caused by silk sericin extract in blood glucose and lipid concentrations in the sera of streptozotocin(STZ, 55 mg/kg B.W., I.P. injection)-induced diabetic rats fed on experimental diets for 5 weeks. Serum concentrations of blood glucose, total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, free cholesterol, cholesteryl ester ratio, triglyceride(TG) and phospholipids(PL) were remarkably higher in the diabetic group(group BSW) and STZ(I.P.)-plus-silk sericin extract group(group ESS) than in the control group(group CG, basal diet-plus-water). However, the serum concentrations of blood glucose, total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, free cholesterol, cholesteryl ester ratio, TG and PL were lower in the ESS group than in the BSW group, whereas the ratio of HDL-cholesterol concentration to total cholesterol and HDL-cholesterol concentration in the ESS group were higher than in the BSW group. The activities of alkaline phosphatase(ALP) and aminotransferase(AST, ALT) in serum were lower in the ESS group than in the diabetic BSW group. The results shown above suggested that silk sericin extract effectively improves blood glucose and lipid concentrations in the sera of STZ-induced diabetic rats.
Keywords
diabetes; silk sericin; blood glucose; lipid concentrations; ALP; aminotransferase;
Citations & Related Records
Times Cited By KSCI : 12  (Citation Analysis)
연도 인용수 순위
1 Lee SH, Cho BN, Hong IJ, Lee MS, Jew SS, Kim DM, Jin DK, Rho SN. 2003. Effects of green tea, cocoon hydrolysates and capsulated components mixture on body fat and serum lipid composition in college women in terms of supplemented periods. J Korean Soc Food Sci Nutr 32:715-722   과학기술학회마을   DOI   ScienceOn
2 Lee DM, Hoffman WH, Carl GF, Cornwell PE. 2002. Lipid peroxidation and antioxidant vitamin prior to durimg and after correction of diabetic ketoacidosis. J Diabetes Complications 16:294-300   DOI   ScienceOn
3 Kim SY, Sohn HR, Bae DG, Kim JH. 2003. Physicochemical characteristic of the silkworm sericin cocoon. Korean J Seric Sci 45:10-17   과학기술학회마을
4 Kim YH. 2008. Effect of bread with added silkworm powder and cholesterol on lipid metabolism of rat. Korean J Food & Nutr 21:306-311   과학기술학회마을
5 Kim JH, Bae DG. 2003. Hydrolysis characteristics and applications of silk sericin. 1. Control of molecular weight of sericin. Korean J Seric Sci 45:46-57   과학기술학회마을
6 Kim JH, Hahm DH, Yang DC, Kim JH, Lee HJ, Shim IS. 2005. Effect of crude saponin of Korean red ginseng on high-fat diet-induced obesity in the rat. Jpn J Pharmacol Sci 97: 124-131   DOI   ScienceOn
7 Kawahara Y, Yamamoto T, Furukawa K, Washika S, Kamei K, Minami H, Nishiuchi S. 2007. Sericin hydrolyzate obtained by hydrothermal treatment and its antioxidant activity. SEN'I GAKKAISHI 63:44-46   DOI   ScienceOn
8 Kim KH. 1980. A translation: The clinical application of the results of the test. pp.164-209, Komoonsa. Seoul. Korea
9 Kim HS, Kim SH, Cheong HS, Kang JO, Chung SY. 1993. Effects of the feeding mixed oils with various levels of n-3 and n-6 polyunsaturated fatty acid on the lipid components and fatty acid metabolism of serum lipoprotein in hyperlipidemic rat. J Kor Soc Food Nutr 22:543-551
10 Kato N, Sato S, Yamanaka A, Yamada H, Fuwa N, Nomura M. 1998. Silk protein, sericin, inhibits lipid peroxidation and tyrosinase activity. Biosci Biotechnol Biochem 62:145-147   DOI   ScienceOn
11 Hugli TE, Moore S. 1972. Determination of the tryptophan content of proteins by ion exchange chromatography of alkaline hydrolysates. J Biol Chem 247:2828-2832
12 Im JG, Kang MS, Park IK, Kim SD. 2005. Dietary effect of Liriopis tuber water extracts on the level of blood glucose and serum cholesterol in streptozotocin-induced diabetic rat. J East Asian Soc Dietary Life 15:20-28   과학기술학회마을
13 Harold J, Holler RD. 1997. Diabetes medical nutrition therapy, A professional guide to management and nutrition education resources. J Am Diet Assoc 97:99-113
14 Jang MJ, Rhee SJ. 2004. Hypoglycemic effects of pills made of mulberry leaves and silkworm powder in streptozotocininduced diabetic rats. J Korean Soc Food Sci Nutr 33:1611-1617   과학기술학회마을   DOI   ScienceOn
15 Kang YK, Choo SK, Nam SH. 2001. The effect of silkwormextract on blood components levels in mice. Korean J Entomology 31:243-247
16 Daniel DG, Saari C, Don WS, Judith MO. 1993. Diabetes increase excretion of urinary malonaldehyde conjugates in rats. Lipids 28:663-666   DOI   ScienceOn
17 Goldberg RR. 1981. Lipid disorders in diabetes. Diabetes Care 4:561-572   DOI   ScienceOn
18 Ha AW, Kim HM. 1999. The study of lipid-peroxidation, antioxidant enzymes and the antioxidant vitamin in NIDDM patients with microvascular-diabetic complications. Korean J Nutr 31:1139-1150
19 Cho HK. 2006. Diabetes mellitus and disorder of lipid metabolism. J Korean Soc Endocrin 21:101-105   DOI   ScienceOn
20 Choi JH, Kim DI, Park SH, Kim JM, Lee JS. Lee KG, Yeo JH, Lee YW. 2000. Effects of silk fibroin on oxidative stress and membrane fluidity in brain of SD rats. Korean J Life Science 10:511-518
21 Chung SH, Yu JH, Kim EJ, Ryu KS. 1996. Blood glucose lowering effect of silkworm. Bull K H Pharma Sci 24: 95-100
22 Yoon JW, Rhee SK, Lee KB. 2005. Effects of silkworm extract powder on plasma lipids and glucose in rats. Korean J Food & Nutr 18:140-145   과학기술학회마을
23 Baron HE, Levy Y, Oschry ZE, Scafrir E. 1984. Removal effect of very low density lipoproteins from diabetic rats. Biochem Biophy Acta 793:115-118   DOI   ScienceOn
24 Wolff SP. 1993. Diabetes mellitus and free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications. Br Med Bull 49:642-652
25 Yeo JH, Lee KG, Woo SO, Kweon HY, Han SM, Park KH, Kim SS. 2007. Dietary effect of silk protein on colon cancer of animal. Korean J Seric Sci 49:67-70   과학기술학회마을
26 Yi KN, Rhee CS. 1996. Clinical Pathology File. pp.101-283. Euihakmunwhasa. Seoul. Korea
27 Yoon JW, Kim CJ, Park CY, McArthur RG. 1987. Effect of environmental factors on development of insulin-dependent diabetes mellitus. Clin Invest Med 10:459-464
28 Son HY, Hotta N, Sukamoto N, Natenoka S, Ohishi N, Yagi N. 1992. Lipoprotein(a) and diabetes mellitus. J Korean Diabetes Assoc 16:275-280
29 Park IK, Lee HS, Lee KY, Ahn YJ, 1988. Cytotoxic activity of Bombyx mori and Morus alba derived materials against human tumor cell lines. Agric Chem Biotech 41:187-190
30 Reitman S, Frankel S. 1957. A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase. Am J Clin Pathol 28:56
31 Lee YK, Lee MY, Kim SD. 2004. Quality characteristics and dietary effect of baguette bread added with water extracts of Liriopis tuber on the blood glucose and serum cholesterol in diabetes induced rats. J East Asian Soc Dietary Life 14: 275-282   과학기술학회마을
32 Tol AV. 1977. Hypertriglyceride in the diabetic rat effective removal of serum very low density lipoproteins. Atherosclerosis 26:117-128   DOI   ScienceOn
33 Mochizuki H, Takido J, Oda H, Yokogoshi H. 1999. Improving effect of dietary taurine on marked hypercholesterolemia induced by a high-cholesterol diet in streptozotocin-induced diabetic rats. Biosci Biotechnol Biochem 63:1984-1987   DOI   ScienceOn
34 Nam JK, Oh YS. 1995. A study of pharmachological effect of silk fibroin RDA. Kor J Agric Sci 37:145-157
35 Nepom GT. 1990. A unified hypothesis for the complex genetics of HLA association. Diabetes 39:1153-1157   DOI   ScienceOn
36 Lee SH, Cho BN, Hyun CK, Jew SS. 2002. Physiological, functional characteristics of silk peptide: Antioxidant effect and immune function. Food Science & Industry 35:57-62
37 Lim SJ, Kim YR. 2004. Effects of Benincasa hispida seeds intake on blood glucose and lipid levels in streptozotocin induced diabetic rats. Kor J Nutr 37:259-265   과학기술학회마을
38 Lee KG, Yeo JH, Lee YM, Kweon HY, Kim JH. 2001. Bioactive and skin-commpatible properties of silk sericin. Korean J Seric Sci 43:109-115
39 Lee JS, Lee MH, Son HS, Maeng YS. 1996. Effects of buckwheat on the activities of pancreatic digestive enzymes in streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr 25:831-838
40 Lee JS, Son HS, Maeng YS, Chang YK, Ju JS. 1994. Effects of buckwheat on organ weight, glucose and lipid metabolism in streptozotocin-induced diabetic rats. Korean J Nutrition 28:819-827
41 Lee MS, Kim DM, Cho BN. Koo SJ, Jew SS, Jin DK, Lee SH. 2003. Study on consequent body fat and serum lipid metabolism after cocoon hydrolysate, green tea leaves and dietary fiber supplementation. J Korean Soc Agric Chem Biotechnol 46:123-129   과학기술학회마을