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Hypoglycemic Effect of Angelica gigas Naki Extract in Streptozotocin-induced Diabetic Rats  

Park, Man-Jong (Food Safely Management Division, Daejeon Regional Food & Drug Administration)
Kang, Shin-Jyung (Dept. of Medicines Resources, Graduate School of Joongbu University)
Kim, Ae-Jung (Dept. of Food & Nutrition, Hyejeon College)
Publication Information
The Korean Journal of Food And Nutrition / v.22, no.2, 2009 , pp. 246-251 More about this Journal
Abstract
This study examined the possible hypoglycemic effects Angelica gigas Naki extracts in streptozotocin-induced diabetic rats(STZ+50%, STZ+100% EtOH and STZ+water). The studies showed that administration of the Angelica gigas Naki extract decreased high blood glucose levels(more than 300 mg/$d{\ell}$) to a normal level(104 mg/$d{\ell}$) in the STZ+50% EtOH group. Liver glucokinase levels were significantly increased in STZ+50% EtOH and STZ+100% EtOH groups compared to the STZ group. Moreover, the liver acetyl CoA carboxylase level was significantly increased in STZ+50% EtOH, STZ+100% EtOH and STZ+water groups compared to the STZ group. These results suggest that the Angelica gigas Naki extract in the STZ+50% EtOH group exerted an ameliorable effect and can be used as an anti-diabetic substance, either as a dietary supplements or as a new drug.
Keywords
Angelica gigas Naki extract; ameliorable effect; streptozotocin-induced diabetes;
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Times Cited By KSCI : 6  (Citation Analysis)
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