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A Study of Antioxidative and Hypoglycemic Activities of Omija(Schizandra chinensis Baillon) Extract under Variable Extract Conditions  

Kim, Sun-Im (Nano Bio-Resources Center, Sookmyung Women's University)
Sim, Ki-Hyeun (Dept. of Food and Nutrition, Sookmyung Women's University)
Ju, Shin-Yoon (Dept. of Food and Nutrition, Sookmyung Women's University)
Han, Young-Sil (Dept. of Food and Nutrition, Sookmyung Women's University)
Publication Information
The Korean Journal of Food And Nutrition / v.22, no.1, 2009 , pp. 41-47 More about this Journal
Abstract
This study investigated antioxidative and hypoglycemic activities of Omija for evaluation of usefulness as a functional food resource. Omija water extracts were extracted with water for 24 hr, 6 hr and 3 hr at room temperature, 60$^{\circ}C$ and 100$^{\circ}C$, respectively. Omija ethanol extracts were extracted with 60% ethanol for 24 hr and 3 hr at room temp temperature and 60$^{\circ}C$, respectively. The antioxidant properties of Omija(Schizandra chinensis Baillon) extracts prepared under different extraction conditions were evaluated by a variety of radical scavenging assays including DPPH, $ABTS^{{cdot}+}$, and nitrite and reducing power. Hypoglycemic activity was examined for $\alpha$-glucosidase inhibition using an in vitro model. The total phenolic content was also determined. Antioxidant activities of Omija were the highest in the group extracted with 60% ethanol for 3 hr. The ethanol extracts showed higher activity than water extracts. An extraction temperature was the highest in 60$^{\circ}C$. The total phenolic content extracted with 60% ethanol for 3 hr at 60$^{\circ}C$ was 530 mg GAE/100 g. The water extract extracted with water for 24 hr at room temperature showed the lowest antioxidant activity and phenolic content. $\alpha$-glucosidase inhibitory activity was the highest in the group extracted with 60% ethanol for 3 hr at 60$^{\circ}C$, followed by the group extracted with 60% ethanol for 24 hr. The results suggest that extraction of Omija by 60% ethanol for 3 hr at 60$^{\circ}C$ will be useful as a functional food resource with natural antioxidants and hypoglycemic activities.
Keywords
Omija(Schizandra chinensis Baillon); variable extract conditions; antioxdant; hypoglycemia; total phenolic content;
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1 Ohtaki, Y, Hida, T, Hiramatsu, K, Kanitani, M, Ohshima, T, Nomura, M, Wakita, H, Aburada, M and Miyamoto, KI. Deoxycholic acid as an endogenous risk factor for hepato carcinogenesis and effects of gomisin A, a lignan component of Schizandra fruits. Anticancer Res. 16:751-755. 1996   PUBMED   ScienceOn
2 Park, JH, Lee, HS, Mun, HC, Kim, DH, Seong, NS, Jung, HG, Bang, JK and Lee, HY. Effect of ultrasonification process on enhancement of immuno-stimulatory activity of Ephedra sinica Stapf and Rubus coreanus Miq. Korean J Biotechnol Bioeng. 19: 113-117. 2004   과학기술학회마을
3 Hikino, H, Takahashi, M, Oshima, Y and Konno, C. Isolation and hypoglycemic activity of oryzabrans A, B, C and D glycan of Oryza sativa bran. Planta Medica. 54:1-3. 1988   DOI   ScienceOn
4 Hermann, BL, Schats, H and Pfeiffer, A. Continuous blood glucose monitoring: the acute effect of acarbose on blood glucose variations. Med Klin. 93:651-655. 1998   DOI   ScienceOn
5 Osawa, T. Novel natural antioxidants for utilization in food and biological systems. In I. Uritani, V. V. Garcia, & E. M. Mendoza (Eds). Postharvest Biochemistry of Plant Food-Materials in the Tropics. pp.241-251. Japan Scientific Societies Press. Tokyo, Japan. 1994
6 Chance, B, Sies, H and Boveris, A : Hydroperoxide metabolism in mammalian organs. Physiol. Res. 59:527-605. 1979   PUBMED   ScienceOn
7 Holasova, M, Fiedlerova, V, Srnrcinova, H, Orsak, M, Lachman, J and Vavreinova, S. Buckwheat the source of antioxidant activity in functional foods. Food Research International. 35:207-211. 2002   DOI   ScienceOn
8 Gheldof, N and Engeseth, NJ. Antioxidant capacity of honeys from various flora sources based on the determination of oxygen radical absorbance capacity and inhibition of vitro lipoprotein oxidation in human senun samples. J. Agricultural and Food Chemistry. 50:3050-3055. 2002   DOI   ScienceOn
9 Shinde, J, Taldone, T, Barletta, M, Kunaparaju, N, Hu, B, Kumar, S, Placido, J and WIlliam, ZS. $\alpha$-Glucosidase inhibitory activity of Syaygium cumini(Linn.) Skeels seed kernel in vitro and in Goto-Kakizaki(GK) rats. Carbohydrate Research. 343:1278-1281. 2008   DOI   PUBMED   ScienceOn
10 Kim, HK, Na, GM, Ye, SH and Han HS. Extraction characteristics and antioxidative activity of Schiznadra chinensis extracts. Korean J Food Culture. 19:484-490. 2004   과학기술학회마을   ScienceOn
11 Zhu, YP, Yin, LJ, Cheng, YQ, Yamaki, K, Mori, Y, Su, YC and Li, LT. Effect of sources of carbon and nitrogen on production of $\alpha$-glucosidase inhibitory by a newly isolated strain of Bacillus subtilis B2. Food Chemistry. 109:737-742. 2008   DOI   ScienceOn
12 Carrascosa, JM, Molero, JC, Fennin, Y, Martinez, C, Andres, A and Satrustegui, J. Extrects of chronic treatment with acasbose on glucose and lipid metabolism in obese diabetic Wistar rats. Diabetes Obes Metab. 3:240-248. 2001   DOI   ScienceOn
13 Nishiyama, N, Chu, PJ and Saito, H. A herbal prescription, S113m, consisting and Schizandra, improves leaming performance in senescence accelerated mouse. BioI. Pharm. Bull. 19:388-393. 1996   DOI   PUBMED   ScienceOn
14 Oyaizu, M. Studies on products of browning reactions: antioxidant activities of products of browning reaction prepared from glucose amine. Japanese J. Nutrition. 44:307-315. 1986   DOI
15 Kim, YM, Jeong, YK, Wang, MH, Lee, WY and Rhee, HI. Inhibitory effect of pine extract on $\alpha$-glucosidase activity and postprandial hyperglycemia. Nutrition. 21:756-761. 2005   DOI   ScienceOn
16 Bae, HC, Cho, IS and Nam, MS. Effects of the biological function of yogurt added with Lycium chinence miller extract. J. Animal Science Technol. 47:1051-1058. 2005   과학기술학회마을   DOI   ScienceOn
17 Kato, H, Lee, IE, Chyen, N, Kim, SB and Hayase, F. UninhibitoIy of nitrosamine fonnation by nondialyzable rnelanoidins. Agric. Bio. Chem. 51:1333-1338. 1987   DOI
18 Lee, WY, Choi, SY, Lee, BS and Park, JS. Optimization of extraction conditions from Omija(Schizandra chinensis Baillon) by response surface methodology. Korean J Food Preserv. 13:252-258. 2006   과학기술학회마을   ScienceOn
19 Lee, JS and Lee, SW. A study on the compositions of free sugar, lipids and nonvolatile organic acids in parts of Omija (Schizandrae chinensis Baillon). Korean J Dietary Culture. 4: 177-179. 1989   과학기술학회마을
20 Baron, AD. Postprandial hyperglycemia and a-glucosidase inhibitors. Diabetes Research and Clinical Practice. 40:51-55. 1998   DOI   ScienceOn
21 Kweon, DJ, Youn, SJ, Cho, HG, Choi, UK and Kang, SC. Antioxidant activities and biological properties of Phellinus linteus extracts according to different extraction methods. J. Korean Soc. Appl. Biol. Chem. 49:91-96. 2006   과학기술학회마을   ScienceOn
22 Jayat, C and Ratinaud, MH. Cell cycle analysis by flow cytometry:principles and applications. BioI. Cell. 78:15-25. 1993   DOI   ScienceOn
23 Re, R, Pellegrini, N, Proteggente, A, Pannala, A, Yang, M and Rice-Evans, C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biology and Medicine. 26:1231-1237. 1999   DOI   ScienceOn
24 Bailey, CJ and Day, C. Traditional plant medicines as treatments for diabetes. Diabetes Care. 12:553-564. 1989   DOI   ScienceOn
25 Blois, MS. Antioxidants determination by the use a stable free radical. Nature. 4617:1199-1200. 1958   DOI   ScienceOn
26 Kim, DH, Park, JH, Kim, JH, Kim, CH, Yuo, JH, Kwon, MC and Lee, HY. Enhancement of immune activities of Ephedrae herba and Rubi fructus at low temperature extraction. Korean J. Medicinal Crop. Sci. 13:81-86. 2005   과학기술학회마을   ScienceOn
27 Choi, SB, Ko, BS, Park, SK, Jang, JS and Park, SM. Insulin sensitizing and TEX>$\alpha$-glucosidase inhibitory action of sennosides, rheins and rhaponticin in Rhei rhizoma. Life Sciences. 78:934-942. 2006   DOI   PUBMED   ScienceOn
28 Yang, HC, Lee, JM and Song, KB. Anthocyanins in cultured Omija(Schizandrae chinensis Bailon) and its stability. J Korean Agr. Chern. Soc. 25:35-43. 1982
29 Yoon, OH and Cho, JS. Optimization of extraction conditions for hot water extracts from Chrysanthemum indicum L. by response surface methodology. Korean J Food Cookery Sci. 23:1-8. 2007   과학기술학회마을   ScienceOn