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Effects of Leucocyanidins on TCDD-Induced Lipid Peroxidation in Female Rat  

Jhee Ok-Hwa (Dept. of Pharmacology & Clinical Pharmacology Lab, Institute of Biomedical Sciences, College of Medicine, Hanyang University, Dept. of Pathology, College of Medicine, Hanyang University)
Lee Joo-Won (Dept. of Pharmacology & Clinical Pharmacology Lab, Institute of Biomedical Sciences, College of Medicine, Hanyang University)
Kim Shin-Hee (Dept. of Pharmacology & Clinical Pharmacology Lab, Institute of Biomedical Sciences, College of Medicine, Hanyang University)
Won Hei-Dan (Dept. of Pharmacology & Clinical Pharmacology Lab, Institute of Biomedical Sciences, College of Medicine, Hanyang University)
Kim Hyun-Jin (Dept. of Pharmacology & Clinical Pharmacology Lab, Institute of Biomedical Sciences, College of Medicine, Hanyang University)
Park Yun-Young (Dept. of Pharmacology & Clinical Pharmacology Lab, Institute of Biomedical Sciences, College of Medicine, Hanyang University)
Kang Min-Jeong (Dept. of Pharmacology & Clinical Pharmacology Lab, Institute of Biomedical Sciences, College of Medicine, Hanyang University, Dept. of Pathology, College of Medicine, Hanyang University)
Park Sung-Kug (Food Additives Team, Korea Food and Drug Administration)
Om Ae-Sun (Dept. of Pathology, College of Medicine, Hanyang University)
Back Seung-Sam (Dept. of Food & Nutrition, College of Human Ecology & Institute of Biomedical Science, Hanyang University)
Kang Ju-Seop (Dept. of Pharmacology & Clinical Pharmacology Lab, Institute of Biomedical Sciences, College of Medicine, Hanyang University)
Publication Information
The Korean Journal of Food And Nutrition / v.18, no.4, 2005 , pp. 295-301 More about this Journal
Abstract
Effects of leucocyanidins on the level of serum lipids and lipid peroxidation was investigated in 2,3,7,8-tetrachlorodibenzo-p-dioxine(TCDD)-induced rat that were pretreated with leucocyanidins for 4 weeks. The rats were divided into five experimental groups that is leucocyanidins and low TCDD treated group(LTL, 0.1 ${\mu}\;g/kg$ TCDD), leucocyanidins treated high TCDD group(LTH, 10 ${\mu}\;g/kg$ TCDD), No leucocyanidins and low TCDD treated group(NTL, 0.1 ${\mu}\;g/kg$ TCDD) and no leucocyanidins and high TCDD treated group(NTL, 10 ${\mu}\;g/kg$ TCDD). Serum total cholesterol, LDL-cholesterol and triglyceride level were significantly decreased and HDL-cholesterol level significantly increased in leucocyanidins treated group. Serum MDA level was also significantly reduced in leucocyanidins treated group. These results suggest that pre-supplement of leucocyanidins prevented the degree of lipid peroxidation on TCDD induced rat.
Keywords
leucocyanidins; TCDD; cholesterol; MDA;
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Times Cited By KSCI : 1  (Citation Analysis)
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