Browse > Article

The Effect of Prunus persica Batch var. davidiana Max. Hot-Water Extract on the Lipid Peroxide and Creatine Phosphokinase Activity in Streptozotocin-Induced Diabetic Rats  

Kim Han-Soo (Department of Biotechnology, Miryang National University)
Publication Information
The Korean Journal of Food And Nutrition / v.18, no.3, 2005 , pp. 272-278 More about this Journal
Abstract
The purpose of this study was designed to observe the effects of the Prunus persica Batsch var. davidiana Max. hot-water extract on the improvement of the glucide and lipid metabolism in the serum of streptozotocin (STZ, 55, mg/kg B.W., I.P. injection)-induced diabetic rats(S.D. strain, male) fed the experimental diets for 5 weeks. Electrolyte(Na, K, Cl) concentration in serum were fairly reduced in the group BSP(basal diet+STZ+Prunus persica $5.0g\%$ extract) than in the STZ(I.P.)-induced diabetic rats group(group BSW, basal diet+STZ(I.P.)+water). Although there was no significant difference among the groups. Concentrations of free fatty acid and lipid peroxide in serum were significantly higher in the STZ-induced diabetic group(group BSW) and STZ+Prunus persica $5.0;g\%$ extract group(group BSP) than those in the control group(group BW, basal diet+water). However, the concentrations of free fatty acid and lipid peroxide in serum were remarkably reduced in the group BSP than those in the group BSW, The activity of creatine phophokinase In serum was significantly lower in the group BSP than in the group BSW However, the activity of LCAT in serum was increased in the group BSP(Prunus persica $5.0\;g\%$ hot-water extract administration group) than in the STZ-induced diabetic group(group BSW). The above results shows that Prunus persica Batsch var. davidiana Max. were effective on the improvement of the glucide and lipid metabolism in serum of streptozotocin-induced diabetic rats.
Keywords
diabetes; Prunus persica; lipid peroxide; creatine phosphokinase; LCAT;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Son, HS. Exercise physiology and diabetes : The riskbenefit profile. Kor. J. Med. 68:603-610. 2005
2 Harold, J and Holler, RD. Diabetes medical nutrition therapy, A professional guide to management and nutrition education resources. J Am. Diet. Assoc. 97:99113. 1997
3 American Diabetes Association. Nutrition recommendations and principles for people with diabetes mellitus (position statement). Diabetes Care 21 (suppl.1): s32- s35. 1998   DOI   ScienceOn
4 Kim, KH. A translation: The clinical application of the results of the test, pp.178-183. Ko Moon Sa, Seoul, Korea. 1980
5 Lim, SJ and Kim, YR. Effects of Benincasa hispida seeds intake on blood glucose and lipid levels in streptozotocin induced diabetic rats. Kor. J. Nutr. 37: 259-265. 2004
6 Seo, JS, Lee, KS and Jang, JH. Effect of dietary supplementation of ${\beta}$-carotene on lipid peroxide level and antioxidative vitamins of diabetic rats. J. Kor. Soc. Food Sci. Nutr. 33:72-77. 2004   DOI
7 Lee, JW, Kim, JE, Park, IW, Lim, SG, Song, KE, Cho, HK, Shin, GT, Kim, HS and Kim, KM. A study on the appropriate normal range of serum creatinine level for Koreans. Kor. J. Nephrol. 23:721-728. 2004
8 Kim, JI, Cho, SJ, Lee, YI, Bae, DS, Lee, SJ and Kim, JS. The serum NPN, BUN and creatinine values in the patient with congestive heart failure. Kor. J. Inter. Med. 27:145-149. 1984
9 Whanger, PD, Weswig, PH, Schmitz, JA and Oldfield, JE. Effects of selenium and vitamin E deficiencies on reproduction, growth, blood components and tissue lesions in sheep fed purified diets. J. Nutr. 107:12881297. 1977
10 Choi, JW, Sohn, KH and Kim, SH. Effects of nicotinamide on the serum lipid composition in streptozotocin induced diabetic rats. J. Kor. Soc. Food Nutr. 20:306-311. 1991
11 한국생양약학교수협의회 편저. 본초학, pp.526-528. 대한약사회. 1994
12 Prakash, R, Parmley, WW and Horvat, M. Serum cortisol, plasma free fatty acids and urinary catecholamines as indicators of complications in acute myocardial infarction. Circulation 45:736-746. 1972   DOI   ScienceOn
13 Yi, KN and Rhee, CS. Clinical pathology file, pp. 128-131. Euihak Munwhasa Co, Seoul, Korea. 1996
14 Zachania, M. Effect of brown rice and soybean dietary fiber on the control of glucose and lipid metabolism in diabetic rats. Am. J. Clin. Nutr. 38:388-393. 1983
15 Yi, KN and Rhee, CS. Clinical pathology file, pp. 245-250. Euihak Munwhasa Co, Seoul, Korea. 1996
16 Wolff, SP. Diabetes mellitus and free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications. Br. Med. Bull. 49:642-652. 1993   DOI
17 Cho, YJ and Bang, MA. Hypoglycemic and antioxidative effects of dietary sea-tangle extracts supplementation in streptozotocin-induced diabetic rats. Kor. J. Nutr. 37:5-14. 2004
18 The expert committee on the diagnosis and classification of diabetes mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 20(suppl. 7):1183-1197. 1997   DOI
19 안경환. 도해고금한방총람, pp.205-206. 서원당. 1980
20 Glomset, JA. Physiological role of lecithin cholesterol acyltransferase. Am. J. Clin. Nutr. 23:1129-1134. 1970
21 Kelly, FJ. Use of antioxidants in the prevention and treatment of disease. J. Int. Fed. Cin. Chem. 10:21-23. 1998
22 Kim, HS, Kim, SH, Kim, GJ, Choi, WJ and Chung, SY. Effects of the feeding mixed oils with various level of n-3 and n-6 polyunsaturated fatty acid on the lipid components of liver, brain, testis and kidney in dietary hyperlipidemic rats. J. Kor. Soc. Food Nutr. 22:685-691. 1993
23 Lee, JJ, Han, IK, Choi, YJ, Kang, JS and Chang, YS. Effects of dietary lipid sources and levels on lecithin cholesterol acyltransferase activity and cholesterol metabolism in rats. Kor. J. Nutr. 26:131-144. 1993
24 Hene, RJ. Effect of high-dose aldosterone infusion on renal electrolyte excretion in patients with renal insufficiency. Am. J. Neph. 7:33-38. 1987   DOI   ScienceOn
25 Macrae, R, Robinson, RK and Sadler, MJ. Encyclopedia of food science, food technology and nutrition, Vol. II pp.1329. Academic Press, New York. 1993
26 신길구. 신씨본초학, pp.562-564. 수문사. 1973
27 Reiter, RJ. The role of the neurohormone melatonin as a buffer against macromolecular oxidative damage. Neurochem. International. 27:453-460. 1995
28 Do, SH, Kwack, KJ, KO, H and Han, BM. A study on the peri operative changes of creatine kinase and lactic dehydrogenase. J. Kor. Soc. Anesth. 24:56-59. 1991   DOI
29 Yoon, JW, Kim, CJ, Park, CY and McArthur, RG. Effect of environmental factors on development of insulin - dependent diabetes mellitus. Clin. Invest. Med. 10:459-466. 1987
30 Kim, HS and Chung, SY. Effects of feeding mixed oils of butter, sardine and safflower on the lipid components in serum and activities of hepatic functional enzyme in rats. J. Kor. Soc. Food Nutr. 21: 608-616. 1992
31 Youk, KC and Youn, SH. Effect of rapit weight reduction on physical fitness and electrolyte. Kor. J. Physi. Edu. 42:719-727. 2003
32 Lee, TH. Diagnosis and classification of diabetes mellitus. Food Indus. and Nutr. 4:61-65. 1999
33 Kim, HS. Effects of the Prunus persica Batsch var. davidiana Max. extract on the blood glucose and serum lipid components in streptozotocin induced diabetic rats. Kor. J. Food & Nutr. 17:337-345. 2004
34 Laybutt, DR, Kaneto, H, Hasenkamp, W, Grey, S, Jonas, JC, Sgroi, DC, Groff, A, Ferran, C, Bonner, WS, Shama, A and Weir, GC. Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to ${\beta}$-cell survival during chronic hyperglycemia. Diabetes 51:413-423. 2002   DOI   ScienceOn