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Effect of Prunus persica Batsch var. davidiana Max. Extract on the Free Fatty Acid, Creatine Phosphokinase and LCAT Activities in Hypercholesterolemic Rats  

Kim Han-Soo (Department of Biotechnology, Miryang National University)
Publication Information
The Korean Journal of Food And Nutrition / v.18, no.3, 2005 , pp. 265-271 More about this Journal
Abstract
This study was performed to observe the effects of the feeding Prunus persica Batsch var davidiana Max. extract on the improvement of the free fatty acid, creatine phosphokinase and lecithin cholesterol acyltransferase(LCAT) activities in the serum of dietary hypercholesterolemic rats(S. D. strain, male) fed the experimental diets for. 5 weeks. Concentration of electrolyte(Na, K, Cl) in serum were fairly reduced in the group BCP(basal diet + cholesterol + Prunus persica, $5.0\;g\%$ extract) than in the group BCW(basal diet + cholesterol + water). However, no significance was found in the effect of an electrolyte concentration among the groups. Concentrations of free fatty acid, lipid peroxide and creatine phosphokinase activity in serum were significantly higher in the cholesterol administration groups(group BCW, BCP) than those in the control group(group BW, basal diet + water). However, concentrations of free fatty acid, lipid peroxide and creatine phosphokinase activity in serum were remarkably lower in the group BCP than those in the group BCW The LCAT activity in serum was increased in the Prunus persica $5.0g\%$ extract administration group(group BCP) than in the cholesterol of diet group(group BCW). From these results, the Prunus persica Batsch var davidiana Max. extracts were found to be effective on the improvement of the lipid compositions in serum of dietary hypercholesterolemic rats.
Keywords
hypercholesterolemia; Prunus persica; free fatty acid; creatine phosphokinase; LCAT;
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1 Holman, RT and Peifer, JJ. The ratio of trienoic, tetraenoic acid in tissue lipids as a measure of EPA requirement. J. Nutr. 70:411-417. 1960
2 Mattson, FH, Erockson, BA and Kligman, AM. Effect of dietary cholesterol on serum cholesterol in man. Am. J. Clin. Nutr. 25:589-594. 1972
3 Hegsted, DM, McGandy, RB and Myers, ML. Quantitative effects of dietary fat on serum cholesterol in man. Am. J. Clin. Nutr. 27:281-295. 1965
4 Frank, GC, Berenson, GS and Webber, LS. Dietary studies and relationship of diet to cardiovascular disease risk factor variables in 10 year old children. Am. J. Clin. Nutr. 31:328-331. 1978
5 Hene, RJ. Effect of high-dose aldosterone infusion on renal electrolyte excretion in patients with renal insufficiency. Am. J. Neph. 7:33-38. 1987   DOI   ScienceOn
6 Youk, KC and Youn, SH. Effect of rapit weight reduction on physical fitness and electrolyte. Kor. J. Physi. Edu. 42(1):719-727. 2003
7 Kim, JI, Cho, SJ, Lee, YI, Bae, DS, Lee, SJ and Kim, JS. The serum NPN, BUN and creatinine values in the patient with congestive heart failure. Kor. J Inter. Med. 27(2):145-149. 1984
8 Yi, KN and Rhee, CS. Clinical pathology file, pp. 128-131. Euihak Munwhasa Co, Seoul, Korea. 1996
9 한국생약학교수협의회 편저. 본초학, pp.526-528. 대한약사회.1994
10 Kim, KH. A translation: The clinical application of the results of the test, pp.178-183. Ko-Moon Sa, Seoul, Korea. 1980
11 Herold, PM and Kinsella, JE. Fish oil consumption and decreased risk of cardiovascular disease : A comparison of findings from animal and human feeding trials. Am. J. Clin. Nutr. 43:566-598. 1985
12 Kim, HS, Kim, SH, Kim, GJ, Choi, WJ and Chung, SY. Effects of the feeding mixed oils with various level of n- 3 and n-6 polyunsaturated fatty acid on the lipid components of liver, brain, testis and kidney in dietary hyperlipidemic rats. J. Kor. Soc. Food Nutr. 22(6):685-691. 1993
13 신길구. 신씨본초학, pp.562-564. 수문사. 1973
14 Hsu, HC, Lee, YT and Chen, MF. Effect of n-3 fatty acids on the composition and binding properties of lipoproteins in hypertriglyceridemic patients. Am. J. Clin. Nutr. 71:28-35. 2000
15 Boulatov, NA, Stenehjem, A and OS, I. Association between albumin: creatinine ratio and 24-hour ambulatory blood pressure in essential hypertension. Am. J. Hyperten. 14:338-344. 2001   DOI   ScienceOn
16 James, WA, Michael, H, Davidson, LB, Virgil, WB, James, WH, Henry, G, Lisa, DAG and Kurt, WW. Long-term cholesterol-lowering effects of psyllium as an adjunct to diet therapy in the treatment of hypercholesterolemia. Am. J. Clin. Nutr. 71:1433-1438. 2000
17 Takanami, Y, Iwane, H, Kawai, T and Shimonitsu, T. Vitamin E supplementation and endurance exercise. Sports Med. 29(2):73-83. 2000   DOI   ScienceOn
18 Yi, KN and Rhee, CS. Clinical pathology file, pp. 245-250. Euihak Munwhasa Co, Seoul, Korea. 1996
19 Reiter, RJ. The role of the neurohormone melatonin as a buffer against macromolecular oxidative damage. Neurochem. Inter. 27(6):453-460. 1995
20 Jensen, JS, Feldt, RB, Borch, JK, Clausen, P, Appleyard, M and Jensen, G. Microalburninuria and its relation to cardiovascular disease and risk factors. A population-based study of 1254 hypertensive individuals. J. Hum. Hyperten. 11:727-732. 1997   DOI   ScienceOn
21 Olofsson, SO. Degradation of high density lipoproteins in vitro. Scand J. Clin. Lab. Invest. 33:137-143. 1974
22 Pickart, L. Increased ratio of plasma free fatty acids to albumin during normal aging and in patients with coronary heart disease. Atherosclerosis 46:21-28. 1983   DOI   PUBMED   ScienceOn
23 Armstrong, ML, Megan, MB and Warnet, ED. Intimal thickening in normocholesterolemic rhesus monkeys fed low supplements of dietary cholesterol. Circu. Res. 34:447-452. 1974   DOI   ScienceOn
24 Prakash, R, Parmley, WW and Horvat, M. Serum cortisol, plasma free fatty acids and urinary catecholamines as indicators if complications in acute myocardial infarction. Circulation 45:736-746. 1972   DOI   ScienceOn
25 McGill, HC. The relationship of dietary cholesterol to serum cholesterol concentration and to atherosclerosis in man. Am. J. Clin. Nutr. 32:2664-2702. 1979
26 안경환. 도해고금한방총람, pp.205-206. 서원당. 1980
27 Kim, HS. Effects of the Prunus per sica Batsch var. davidiana Max. extract on the lipid compositions and enzyme activities in hyperlipidemic rats. Kor. J. Food & Nutr. 17(3):328-336. 2004
28 Kim, HS. Effects of the Prunus persica Batsch var. davidiana Max. extract on the blood glucose and serum lipid components in streptozotocin induced diabetic rats. Kor. J. Food & Nutr. 17(3):337-345. 2004
29 Sabine, W, Matthias, O, Andreas, A, Karen, O and Claus, L. Postprandial chylomicrons and VLDLs in severe hypertriacylglycerolemia are lowered more effectively than are chylomicron remnants after treatment with n-3 fatty acids. Am. J. Clin. Nutr. 71:914-920. 2000
30 Dietschy, JM and Wilson, JD. Regulation of cholesterol metabolism. New Engl. J. Med. 282:1128-1241. 1970   DOI   ScienceOn
31 Lee, JJ, Han, IK, Choi, YJ, Kang, JS and Chang, YS. Effects of dietary lipid sources and levels on lecithin cholesterol acyltransferase activity and cholesterol metabolism in rats. Kor. J. Nutr. 26(2): 131-144. 1993
32 Do, SH, Kwack, KJ, Ko, H and Han, BM. A study on the peri operative changes of creatine kinase and lactic dehydrogenase. J. Kor. Soc. Anesth. 24(1):56-59. 1991   DOI
33 Kim, CK, Han, YH, Cho, HI, Rhee, KJ, Lim, KB and Yoo, WS. Effect of glucose on plasma free fatty acid and triglyceride. Kor. J. Inter. Med. 21(6):512-516. 1978
34 Song, MS, Kim, HS and Yoo, YS. Increase in systolic blood pressure and creatinine among type 2 diabetic patients with microalbuminuria. J Kor. Comm. Heal. Nur. Aca. Soc. 16(2):346-353. 2002
35 Glomset, JA. Physiological role of lecithin cholesterd acyltransferase. Am. J. Clin. Nutr. 23:1129-1134.1970
36 Bang, HO, Dyerberg, J and Sinclair, HM. The composition of the Eskimo food in north western Greenland. Am. J. Clin. Nutr. 33:2657-2661. 1980
37 Choi, WJ, Kim, HS, Kim, SH, Yi, HS, Su, IS and Chung, SY. Effects of feeding the mixture linseed and sunflower seed oil on the lipid components and fatty acid compositions of liver in dietary hyperlipidemic rats. J. Kor. Soc. Food Nutr. 23(2):198-204. 1994