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Effects of Allicin on Cytokine Production Genes of Human Peripheral Blood Mononuclear Cells  

박란숙 (숭의여자대학 식품영양과)
Publication Information
The Korean Journal of Food And Nutrition / v.15, no.3, 2002 , pp. 191-196 More about this Journal
Abstract
The effect of allicin, the major component of garlic (Allium sativum), on the gene expression profiles of peripheral blood mononuclear cells from healthy donors was analyzed. DNA microarray which can detect expression signal of 862 genes revealed that allicin induced the expression of cytokine, chemokine, and immune-related genes in peripheral blood mononuclear cells. In contrast, allicin repressed the expression of adaptive immune-related genes, which are expressed in T helper 1 Iymphocytes. Simultaneous inhibitory and stimulatory effects of allicin were found on inflammatory cells. It is likely that allicin down-regulated the expression of specific genes that were previously up-regulated in resting cells, suggesting a new mechanism by which they exert positive and negative effect. Considering the broad and renewed interest in allicin, the profiles we describe here will be useful in designing more specific and efficient treatment strategies.
Keywords
allicin; garilic; gene expression; microarray;
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