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http://dx.doi.org/10.15429/jkomor.2021.21.2.49

Effects of White Pan Bread Added with Kamut (Triticum turgidum spp.) on High Fat Diet-Induced Obese C57BL/6 Mice  

Jung, Hyun Gi (Department of Food Science, Gyeongsang National University)
Baek, Ji Yun (Department of Food Science, Gyeongsang National University)
Choi, Ye Jung (College of Korean Medicine, Gachon University)
Kang, Ki Sung (College of Korean Medicine, Gachon University)
Kim, Hyun Young (Department of Food Science, Gyeongsang National University)
Kim, Ji Hyun (Department of Food Science, Gyeongsang National University)
Choi, Jine Shang (Department of Food Science, Gyeongsang National University)
Publication Information
Journal of Korean Medicine for Obesity Research / v.21, no.2, 2021 , pp. 49-58 More about this Journal
Abstract
Objectives: The purpose of this study was to investigate the effect of white pan bread added with Kamut (Triticum turgidum spp.) on high fat diet (HFD)-induced obese C57BL/6 mice. Methods: The white pan bread or white pan bread with Kamut (BK) were administered for 8 weeks in HFD-induced obese C57BL/6 mice. To evaluate the effect and its mechanisms of BK on obese mice, we measured body weight change, serum lipid profiles, histopathological analysis, and protein expression of CCAAT/enhancer binding protein-α (C/EBPα) in the liver. Results: Administration of BK significantly decreased body weight in HFD-induced obese mice. In addition, BK-administered group significantly reduced serum total cholesterol, glucose, and high-density lipoprotein cholesterol levels compared with the HFD-induced control group. The HFD-induced mice had damaged liver tissue and increased the size of adipose tissue, but BK-administered group attenuated liver damage and decreased the size of adipocyte. Furthermore, administration of BK significantly down-regulated C/EBPα in the liver compared with HFD-fed mice. In particular, BK-administered group has higher inhibited body weight, serum lipid profiles, and C/EBPα expressions than white pan bread-administered group. Conclusions: This study demonstrated that administration of BK attenuated HFD-induced obesity by regulation of C/EBPα than consumption of white pan bread. Therefore, BK could be developed as a bread for prevention of obesity.
Keywords
High-fat diet; Obesity; Triticum; Kamut; White pan bread;
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