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http://dx.doi.org/10.4489/KJM.2015.43.3.174

Antihyperglycemic α-Glucosidase Inhibitory Activity of Ethanol Extract from Neolentinus lepideus  

Shin, Ja-Won (Department of Biomedicinal Science and Biotechnology, Paichai University)
Bae, Sang-Min (Department of Biomedicinal Science and Biotechnology, Paichai University)
Han, Sang-Min (Department of Biomedicinal Science and Biotechnology, Paichai University)
Lee, Yun-Hae (Mushroom Research Institute, Gyeonggi-do Agricultural Research & Extension Services)
Kim, Jeong-Han (Mushroom Research Institute, Gyeonggi-do Agricultural Research & Extension Services)
Ji, Jeong-Hyun (Mushroom Research Institute, Gyeonggi-do Agricultural Research & Extension Services)
Lee, Jong-Soo (Department of Biomedicinal Science and Biotechnology, Paichai University)
Publication Information
The Korean Journal of Mycology / v.43, no.3, 2015 , pp. 174-179 More about this Journal
Abstract
For development a new anti-diabetic compound from edible mushroom, antihyperglycemic ${\alpha}$-glucosidase inhibitory activities of Pleurotus ostreatus, Pleurotus cornucopiae, Pleurotus salmoneostramineus, Pleurotus eryngii and Neolentinus lepideus were investigated on its water and ethanol extracts. ${\alpha}$-Glucosidase inhibitory activity of Neolentinus lepideus fruiting body showed the highest at 86.3% in the 95% ethanol extracts and water extract from Pleurotus cornucopiae was also higher at 48.5% among water extracts. Therefore, Neolentinus lepideus which showed very high ${\alpha}$-glucosidase inhibitory activity was selected as a new anti-diabetic agent-containing mushroom and the ${\alpha}$-glucosidase inhibitor was maximally extracted when treated with 95% ethanol at $30^{\circ}C$ for 48 hr. The ethanol extracts from Neolentinus lepideus fruiting body showed dosage-dependent hypoglycemic action after administration to 120 min in the SD-rat and streptozotocin-induced diabetic SD-rat.
Keywords
Antihyperglycemic effect; ${\alpha}$-Glucosidase inhibitor; Neolentinus lepideus;
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Times Cited By KSCI : 15  (Citation Analysis)
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