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http://dx.doi.org/10.1007/s10068-018-0431-0

Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome  

Jo, Kyungae (Department of Public Health Science, Korea University)
Kim, Hoon (Skin Biotechnology Center, Kyung Hee University)
Choi, Hyeon-Son (Department of Food Science and Technology, Seoul Women's University)
Lee, Seung-Su (Skin Biotechnology Center, Kyung Hee University)
Bang, Myun-Ho (Skin Biotechnology Center, Kyung Hee University)
Suh, Hyung Joo (Department of Public Health Science, Korea University)
Publication Information
Food Science and Biotechnology / v.27, no.6, 2018 , pp. 1833-1842 More about this Journal
Abstract
The aim of this study was to identify sleep-promoting substance from Polygonatum sibiricum rhizome extract (PSE) with the regulation of sleep architecture. PSE showed a decrease in sleep latency time and an increase in the sleeping time. In the electroencephalography analysis of rats, PSE (150 mg/kg) showed an increase of non-rapid eye movement by 38% and a decrease of rapid eye movement by 31% compared to the control. This sleep-promoting activity was found to be involved in the $GABA_A$-BDZ receptor. The chemical structure of the pure compound was determined by the $^1H$ and $^{13}C$ nuclear magnetic resonance spectroscopy and gas chromatography mass spectrometry analysis; active compound was glyceryl-1-monolinoleate. The commercial standard glyceryl-1-monolinoleate showed a similar inhibitory concentration on [$^3H$]-flumazenil binding to $GABA_A$-BDZ receptors with final active fraction of PSE. The results indicate that glyceryl-1-monolinoleate is a major active compound responsible for the PSE-derived sleep promotion.
Keywords
Glyceryl monolinoleate; Polygonatum sibiricum; Insomnia; Sleep; GABA type A-benzodiazepine receptor;
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