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Effects of Surfactants on the Formation and Stability of Capsaicinloaded Nanoemulsions  

Choi, Ae-Jin (Department of Herbal Crop Research, National Institute of Horticulture & Herbal Science, Rural Development Administration)
Kim, Chul-Jin (Bio-Nano Research Center, Korea Food Research Institute)
Cho, Yong-Jin (Bio-Nano Research Center, Korea Food Research Institute)
Hwang, Jae-Kwan (Department of Biotechnology, Yonsei University)
Kim, Chong-Tai (Bio-Nano Research Center, Korea Food Research Institute)
Publication Information
Food Science and Biotechnology / v.18, no.5, 2009 , pp. 1161-1172 More about this Journal
Abstract
Food nanoemulsion systems consisting of water and oleoresin capsicum (OC), polyoxythylene sorbitan esters (Tween 20, 40, 60, and 80), propylene glycol (PG), sucrose monostearate (SM), and their corresponding mixtures were formulated to use as food vehicles. Tween 80 produced OC nanoemulsions with stable dispersions as one-phase systems, and the dertermined emulsification efficiencies clearly distinguished the ability of the various surfactants to emulsify OC. The nanoemulsions were prepared by both ultrasonication and self-assembly, and the nanoemulsion areas were determined using phase diagrams by measuring the sizes of the emulsions. One-phase nanoemulsions were presented, with a multiple cloudy region and phase separation that were dependent on the particle size of the emulsion. The OC nanoemulsions prepared by ultrasonication using systems of OC/Tween 80/water, OC/Tween 80/water+PG, and OC/Tween 80/water+SM, resulted in particle sizes ranging from 15 to 100 nm. Finally, the nanoemulsions maintained their initial sizes during storage, ranging from 65 to 92 nm.
Keywords
food nanoemulsion; self-assembly; surfactant; bioactive delivery system; oleoresin capsicum;
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1 Kopec SE, Debellis RJ, Irwin RS. Chemical analysis of freshly prepared and stored capsaicin solutions: Implications for tussigenic challenges. Pulm. Pharmacol. Ther. 15: 529-534 (2002)   DOI   ScienceOn
2 Yaghmur A, Aserin A, Garti N. Furfural-cysteine model reaction in food grade nonionic oil/water microemulsions for selective flavor formation. J. Agr. Food Chem. 50: 2878-2883 (2002)   DOI   ScienceOn
3 Lamaallam S, Bataller H, Dicharry C, Lachaise J. Formation and stability of miniemulsions produced by dispersion of water/oil/ surfactants concentrates in a large amount of water. Colloid Surface A 270-271: 44-51 (2005)   DOI   ScienceOn
4 Izquierdo P, Esquena J, Tadros TF, Dederen JC, Feng J, Garcia- Celma MJ, Azemar, N, Solans C. Phase behavior and nanoemulsion formation by the phase inversion temperature method. Langmuir 20: 6594-6598 (2004)   DOI   ScienceOn
5 Izquierdo P, Esquena J, Tadros TF, Dederen JC, Garcia-Celma MJ, Azemar N, Solans C. The influence of surfactant mixing ratio on nano-emulsion formation by the pit method. J. Colloid Interf. Sci. 285: 388-394 (2005)   DOI   ScienceOn
6 Garti N, Spernath A, Aserin A, Lutz R. Nano-sized self-assemblies of nonionic surfactant as solubilization reservoirs and microreactors for food system. Roy. Soc. Chem. 1: 206-218 (2005)
7 Davis B, Markey E, Busch A, Busch W. Determination of capsaicinoids in habanero peppers by chemometric analysis of UV spectral data. J. Agr. Food Chem. 55: 5925-5933 (2007)   DOI   ScienceOn
8 Yu W, Tabosa DE, Barrat ES, Fessi G, Devissaguet JP, Puisieux F. A novel approach to the preparation of injectable emulsions by spontaneous emulsification process. Int. J. Pharm. 89: 139-146 (1993)   DOI   ScienceOn
9 Patel N, Schmid U, Lawrence MJ. Phospholipid-based microemulsions suitable for use in foods. J. Agr. Food Chem. 54: 7817-7824 (2006)   DOI   ScienceOn
10 Jafari SM, Yinghe HB, Bhandari B. Nano-emulsion production by sonication and microfluidization-a comparison. Int. J. Food Prop. 9: 475-485 (2006)   DOI   ScienceOn
11 Lawrence MJ, Ress GD. Microemulsion-based media as novel drug delivery systems. Adv. Drug Deliver Rev. 45: 89-121   DOI   ScienceOn
12 Wang L, Mutch KJ, Eastoe J, Heenan RK, Dong J. Nanoemulsions prepared by a two-step low-energy process. Langmuir 24: 6092- 6099 (2008)   DOI   ScienceOn
13 Baran JR, Wade WH. Temperature insensitive microemulsion phase with nonionic surfactants. J. Disper. Sci. Technol. 16: 165-188 (1995)   DOI   ScienceOn
14 Izquierdo P, Esquena J, Tadros TF, Dederen JC, Garcia-Celma MJ, Azemar N, Solans C. Formation and stability of nano-emulsions prepared using the phase inversion temperature method. Langmuir 18: 26-30 (2002)   DOI   ScienceOn
15 Tan CP, Nakajima M. $\beta$-Carotene nanodispersions: Preparation, characterization, and stability evaluation. Food Chem. 92: 661-671 (2005)   DOI   ScienceOn
16 Tardors T, Izquierdo P, Esquena J, Solans C. Formation and stability of nano-emulsions. Adv. Colloid Interfac. 108-109: 303-318 (2004)   DOI   ScienceOn
17 Yuan Y, Gao Y, Zhao J, Mao L. Characterization and stability evaluation of β-carotene nanoemulsions prepared by high pressure homogenization under various emulsifying conditions. Food Res. Int. 41: 61-68 (2008)   DOI   ScienceOn
18 Garti N, Yaghmur A, Leser ME, Clement V, Watzke HJ. Improved oil solubilization in oil/water food grade microemulsions in the presence of polyols and ethanol. J. Agr. Food Chem. 49: 2552-2562 (2001)   DOI   ScienceOn
19 Choi AJ, Kim CJ, Cho YJ, Hwang JK, Kim CT. Solubilization of capsaicin and its nanoemulsion formation in the sonication and selfassembly methods. p. 61. In: NSTI Nanotech Conference. June 4, The Hynes Convention Center, Boston, MA, USA. Nano Science & Technology Institute, Huston, TA, USA (2008)
20 Lee KW, Lee HJ, Surh YJ, Lee CY. Vitamin C and cancer chemoprevention: Reappraisal. Am. J. Clin. Nutr. 78: 1074-1078 (2003)
21 Israelchvili JN, Mitchell DJ, Ninhan BW. Theory of self assembly of hydrocarbon amphiphiles into micelles and bilayers. J. Chem. Soc. Faraday T2. 72: 1525-1568 (1976)   DOI   ScienceOn
22 Govindarajan VS, Sathyanarayana MN. Capsicum. Production, technology, chemistry, and quality. Part V. Impact on physiology, pharmacology, nutrition, and metabolism; structure, pungency, pain, and desensitization sequences. Crit. Rev. Food Sci. 29: 435-475 (1991)   DOI   ScienceOn
23 Garti N, Clement V, Fanun M, Leser ME. Some characteristics of sugar ester nonionic microemulsions in view of possible food applications. J. Agr. Food Chem. 48: 3945-3956 (2000)   DOI   ScienceOn
24 Spernath A, Yaghmur A, Aserin A, Hoffman RE, Garti N. Foodgrade microemulsions based on nonionic emulsifiers: Media to enhance lycopene solubilization. J. Agr. Food Chem. 50: 6917-6922 (2002)   DOI   ScienceOn
25 Reilly CA, Ehlhardt WJ, Jackson DA, Kulanthaivel P, Mutlib AE, Espina RJ, Moody DE, Crouch DJ, Yost, GS. Metabolism of capsaicin by cytochrom P450 produces novel dehydrogenated metabolites and decrease cytotoxicity to lung and liver cells. Chem. Res. Toxicol. 16: 336-339 (2003)   DOI   ScienceOn
26 Rang MJ, Miller CA. Spontaneous emulsification of oils containing hydrocarbon, nonionic surfactant, and oleyl alcohol. J. Colloid Interfac. 209: 179-192 (1999)   DOI   ScienceOn
27 Morales D, Gutie'rrez JM, Garcia-Celma JM, Solans C. A study of the relation between bicontinuous microemulsions and oil/water nano-emulsion formation. Langmuir 19: 7196-7200 (2003)   DOI   ScienceOn
28 Bataller H, Lamaallam S, Lachaise J, Graciaa A, Dicharry C, Mater J. Cutting fluid emulsions produced by dilution of a cutting fluid concentrate containing a cationic/nonionic surfactant mixture. J. Mater. Process. Tech. 152: 215-220 (2004)   DOI   ScienceOn
29 Forgiarini A, Esquena J, Gonza'lez C, Solans C. Formation of nanoemulsions by low-energy emulsification methods at constant temperature. Langmuir 17: 2076-2083 (2001)   DOI   ScienceOn
30 Kawakami K, Yoshikawa T, Moroto Y, Kanaoka E, Takahashi K, Nishihara Y, Masuda K. Microemulsion formulation for enhanced absorption of poorly soluble drugs I. Prescription design. J. Control. Release 81: 65-74 (2002)   DOI   ScienceOn
31 Forgiarini A, Esquena J, Gona'lez C, Solans C. Studies of the relation between phase behavior and emulsification methods with nanoemulsion formation. Progr. Coll. Pol. Sci. S 115: 36-39 (2000)   DOI
32 Surh J, McClements DJ. Influence of salt concentrations on the stabilities and properties of sodium casemate stabilized oil-in-water emulsions. Food Sci. Biotechnol. 17: 8-14 (2008)
33 Cho YJ, Kim CJ, Kim NS, Kim CT, Park B. Some cases in applications of nanotechnology to food and agricultural systems. Biochip J. 2: 183-185 (2008)
34 Pons R, Carrera I, Caelles J, Rouch J, Panizza P. Formation and properties of miniemulsions formed by microemulsions dilution. Adv. Colloid Interfac. 106: 129-146 (2003)   DOI   ScienceOn
35 Molina-Torres J, Garc$\acute{i}$a-Ch$\acute{a}$vez A, Ram$\acute{i}$rez-Ch$\acute{a}$vez E. Antimicrobial properties of alkamides present in flavoring plants traditionally used in Mesoamerica: Affinin and capsaicin. J. Ethnopharmacol. 64: 241-248 (1999)   DOI   ScienceOn
36 Kim CT, Choi AJ, Kim CJ, Cho YJ. Preparation of food nanoemulsions containing bioactive ingredients and its application for use as nutraceutical delivery system. p. 454. In: The 6th International Nanotech Symposium & Exhibition-Nano Korea 2008. August 30, KINTEX, Gyeonggi, Korea. Nano Technology Research Association, Seoul, Korea (2008)