Anti-inflammatory Effect of Dangyuja (Citrus grandis Osbeck) Leaves in LPS-stimulated RAW 264.7 Cells
![]() ![]() |
Yang, Eun-Jin
(Department of Pharmacology, College of Medicine, Jeju National University)
Lee, Hye-Ja (Department of Pharmacology, College of Medicine, Jeju National University) Kang, Gyeoung-Jin (Department of Pharmacology, College of Medicine, Jeju National University) Park, Sun-Soon (Department of Pharmacology, College of Medicine, Jeju National University) Yoon, Weon-Jong (Department of Pharmacology, College of Medicine, Jeju National University) Kang, Hee-Kyoung (Department of Pharmacology, College of Medicine, Jeju National University) Cho, So-Mi Kim (Faculty of Biotechnology, College of Applied Life Sciences, Jeju National University) Yoo, Eun-Sook (Department of Pharmacology, College of Medicine, Jeju National University) |
1 | Tian Q, Miller EG, Ahmad H, Tang L, Patil BS. Differential inhibition of human cancer cell proliferation by Citrus limonoids. Nutr. Cancer 40: 180-184 (2001) DOI ScienceOn |
2 |
Choi CY, Park KR, Lee JH, Jeon YJ, Liu KH, Oh S, Kim DE, Yea SS. Isoeugenol suppression of inducible nitric oxide synthase expression is mediated by down-regulation of NF- |
3 | Moeslinger T, Friedl R, Spieckermann PG. Inhibition of inducible nitric oxide synthesis by azathioprine in a macrophage cell line. Life Sci. 79: 374-381 (2006) DOI ScienceOn |
4 | Huang GC, Chow JM, Shen SC, Yang LY, Lin CW, Chen YC. Wogonin but not nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophage. Int. Immunopharmacol. 7: 1054-1063 (2007) DOI ScienceOn |
5 | Son CG, Shin JW, Cho JH,Cho CK, Yun CH, Chung W, Han SH. Macrophage activation and nitric oxide production by water soluble components of Hericum erinaceum. Int. Immunopharmacol. 6: 1363-1369 (2006) DOI ScienceOn |
6 | Oka Y, Ibuki T, Matsumura K, Namba M, Yamazaki Y, Poole S, Tanaka Y, Kobayashi S. Interleukin-6 is a candidate molecule that transmits inflammatory information to the CNS. Neuroscience 145: 530-538 (2007) DOI ScienceOn |
7 | Rossi A, Kapahi P, Natoli G, Takahashi T, Chen Y, Karin M, Santoro MG. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature 403: 103-108 (2000) DOI ScienceOn |
8 | Guha M, Mackman N. LPS induction of gene expression in human monocytes. Cell. Signal. 13: 85-94 (2001) DOI ScienceOn |
9 | Pan MH, Lai CS, Wang YJ, Ho CT. Acacetin suppressed LPSinduced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice. Biochem. Pharmacol. 72: 1293-1303 (2006) DOI ScienceOn |
10 | Rao KM. MAP kinase activation in macrophage. J. Leukocyte Biol. 69: 3-10 (2001) PUBMED |
11 | Gerlier D, Thomasser N. Use of MTT colorimetricassay to measure cell activation. J. Immunol. Methods 94: 57-63 (1986) DOI PUBMED ScienceOn |
12 | Ishiwa J, Sato T, Mimaki Y, Sashida Y, Yani M, Ito A. A citrus flavonoid, nobiletin, suppresses production, and gene expression of matrix metalloproteinase 9/gelatinase B in rabbit synovial fibroblast. J. Rheumatol. 27: 20-25 (2000) PUBMED |
13 | Lane TE, Otero GC, Wu-Heish BA, Howard DH. Expression of inducible nitric oxide synthase by stimulated macrophage correlates with their antihistoplasma activity. Infect. Immun. 62: 1478-1479 (1994) PUBMED |
14 | Kim JY, Park SJ, Yun KJ, Cho YW, Park HJ, Lee KT. Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-kappaB in RAW 264.7 macrophage. Eur. J. Pharmacol. 584: 175-184 (2008) DOI ScienceOn |
15 | De Filippis D, Iuvone T, Esposito G, Steardo L, Arnole GH, Paul AP, De Man Joris G, De Winter Bebedicate Y. Melatonin reverse lipopolysaccharide-induced gastro-intestinal motility disturbances through the inhibition of oxidative stress. J. Pineal Res. 44: 45-41 (2008) PUBMED |
16 |
Kim JH, Kim DH, Baek SH, Lee HJ, Kim MR, Kwon HJ, Lee CH. Rengyolone inhibits inducible nitric oxide synthase expression and nitric oxide production by down-regulation of NF- |
17 | Raingeaud J, Gupta S, Rogers JS, Dickens M, Han J, Ulveitch RJ, Davis RJ. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on trypsin and threonine. J. Biol. Chem. 270: 7420- 7426 (1995) DOI ScienceOn |
18 | Murakami A, Nakamura Y, Torikai Y, Tanaka T, Koshiba T, Koshimizu H, Kuwahara S, Takahashi Y, Ogawa K, Yano M, Tokuda H, Nishino H, Mimaki Y, Sashida Y, Kitanaka S, Ohigashi H. Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice. Cancer Res. 60: 5059-5066 (2000) PUBMED |
19 |
Jung CH, Kim JH, Hong MH, Seog HM, Oh SH, Lee PJ, Kim GJ, Kim HM, Um JY, Ko SG. Phenolic-rich fraction from Rhus verniciflua strokes (RVS) suppress inflammatory response via NF- |
20 | Lappas M, Permezel M, Rice GE. Mitogen-activated protein kinase proteins regulates LPS-stimulated release of pro-inflammatory cytokines and prostaglandins from human gestational tissues. Placenta 28: 936-945 (2007) DOI ScienceOn |
21 | Daikonya A, Katsuki S, Kitanaka S. Antiallergic agents from natural sources 9. Inhibition of nitric oxide production by novel chalcone derivatives from Mallotus philippinensis (Euphorbiaceae). Chem. Pharm. Bull. 52: 1326-1329 (2004) DOI ScienceOn |
22 | Olszanecki R, Gebska A, Kozlovski VI, Gryglewski RJ. Flavonoids and nitric oxide synthase. J. Physiol. Phamacol. 53: 571-584 (2002) |
23 | Weiss J. Hutzler M, Kao L. Environmental modulation of lipopolysaccharide chain length alters the sensitivity Escherichia coli to the neutrophil bactericidal/permeability-increasing protein. Infect. Immun. 51: 594-599 (1986) PUBMED |
24 | Snell JC, Colton CA, Chernvshev ON, Gilgert DL. Locationdependent artifact for no measurement using multiwell plates. Free Radical Bio. Med. 20: 361-363 (1996) DOI ScienceOn |
25 |
Pokharel YR, Liu QH, Woo ER, Kang KW. 4-Hydrosykobusin inhibits the induction of nitric oxide synthase by inhibiting NF- |
26 | Lee HJ, Kang GY, Yoon WJ, Kang HK, Kim YS, Kim SM, Yoo ES. Anti-inflammatory effect of unripe fruit of Citrus grandis Osbeck in RAW 264.7 and HaCaT cells. Korean J. Pharmacogn. 37: 74-80 (2006) |
27 | Jeon KI, Jeong JY, Jue DM. Thiol-reactive metal compounds inhibit NF-kappaB activation by blocking I kappa B kinase. J. Immunol. 164: 5981-5989 (2000) |
28 | Ghazizadeh M. Essential role of IL-6 signaling pathway in keloid pathogenesis. J. Nippon Med. Sch. 74: 11-22 (2007) DOI |
29 | Lim HK, Yoo ES, Moon JY, Jeon YJ, Kim SM, Cho SK. Antioxidant activity of extracts from dangyuja (Citrus grandis Osbeck) fruits produced in Jeju Island. Food Sci. Biotechnol. 15: 312-316 (2006) |
30 | Cho JY, Baik KU, Jung JH, Park MH. In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa. Eur. J. Pharmacol. 398: 399-407 (2000) DOI ScienceOn |
31 | Irie T, Muta T, Takeshige K. TAK1 mediates an activation signal from toll-like receptor(s) to nuclear factor-kappaB in lipopolysaccharidestimulated macrophages. FEBS Lett. 467: 160-164 (2000) DOI PUBMED ScienceOn |
32 | Lee SJ, Lim KT. Phytoglycoprotein inhibits interleukin-1beta and interleukin-6 via p38 mitogen-activated protein kinase in lipopolysaccharide-stimulated RAW 264.7 cells. N-S Arch. Pharmacol. 377: 45-54 (2008) DOI ScienceOn |
33 | Rawadi G, Ramez V, Lemercier B, Roman-Roman S. Activation of Mitogen-activated protein kinase pathways by Mycoplasma fermentans membrane lipoproteins in murine macrophages: Involvement in cytokine synthesis. J. Immunol. 160: 1330-1339 (1998) |
34 | Liu Y. Understanding the biological activity of amyloid proteins in vitro: From inhibited cellular MTT reduction to altered cellular cholesterol homeostasis. Prog. Neuro.-Psychoph. 23: 377-395 (1999) DOI ScienceOn |
35 | Schorey JS, Cooper AM. Macrophage signaling upon mycobacterial infection: The MAP kinase lead the way. Cell. Microbiol. 2: 133- 142 (2003) |
36 | Kim YJ, Cho MJ, Kim SM, Cho SK. In vitro antioxidant and cytoprotective activities of the extract of dangyuja (Citrus grandis Osbeck) leaves. Food Sci Biotecnol. 17: 1086-1091 (2008) |
37 | Woo ER, Lee JY, Cho IJ, Kim SG, Kang KW. Amentoflavone inhibits the induction of nitric oxide synthase by inhibiting NFkappaB activation in macrophage. Pharmacol. Res. 51: 539-546 (2005) DOI ScienceOn |
38 | Kim JB, Han AR, Park EY, Kim JY, Cho W, Lee J, Seo EK, Lee KT. Inhibition of LPS-induced iNOS, COX-2, and cytokines expression by poncrin through the NF-kappaB inactivation in RAW 264.7 macrophage cells. Biol. Pharm. Bull. 30: 2345-2351 (2007) DOI PUBMED ScienceOn |
39 |
Kwak HJ, Song JS, Heo JY, Yang SD, Nam JY, Cheon HG. Roflumilast inhibits lipopolysaccharide-induced inflammatory mediators via suppression of nuclear factor- |
![]() |