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Effect of Prunella vulgaris Labiatae Extract on Innate Immune Cells and Anti-metastatic Effect in Mice  

Lee, Jun-Beom (Shin Women's Hospital)
Kang, Tae-Bong (Department of Biological Chemistry, The Weizmann Institute of Science)
Choi, Sang-Hoon (Department of Aquaculture Life Medicine, Kunsan National University)
Lee, Ui-Young (Sanyacho-Nongwon)
Kim, Ae-Jung (Department of Food and Nutrition, Hyejeon College)
Jeong, Chang-Jin (Shin Women's Hospital)
Lee, Hak-Cheon (Shin Women's Hospital)
Cho, Yong-Sun (Shin Women's Hospital)
Won, Jong-Gun (Shin Women's Hospital)
Lim, Jong-Cheol (Shin Women's Hospital)
Yoon, Taek-Joon (Department of Food and Nutrition, Yuhan College)
Publication Information
Food Science and Biotechnology / v.18, no.1, 2009 , pp. 218-222 More about this Journal
Abstract
Ability of water extract from Prunella vulgaris Labiatae to stimulate immune system and inhibit tumor metastasis in mice was assessed. In experimental lung metastasis, prophylactic intravenous (i.v.) administration of water extract from P. vulgaris significantly inhibited lung metastasis in a dose-dependant manner. Peritoneal macrophages stimulated with P. vulgaris produced various cytokines such as tumor necrosis factor (TNF)-$\alpha$ and interlukin (IL)-12 as well as induced tumoricidal activity. In an assay for natural killer (NK) cell activity, i.v. administration of P. vulgaris significantly augmented NK cytotoxicity. The depletion of NK cells by injection of rabbit anti-asialo GM1 serum abolished the inhibitory effect of P. vulgaris on lung metastasis of colon26-M3.1 cells. These data demonstrate that P. vulgaris activate innate immune system to inhibit the growth of foreign materials including tumor cells in mice.
Keywords
Prunella vulgaris L.; innate immunity; tumor metastasis; cytokine;
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