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Effects of $\gamma$-Irradiation on the Antiallergic Activity of Alginate  

Song, Eu-Jin (Faculty of Food Science and Biotechnology/Institute of Food Science, Pukyong National University)
Lee, So-Young (Faculty of Food Science and Biotechnology/Institute of Food Science, Pukyong National University)
Kim, Koth-Bong-Woo-Ri (Faculty of Food Science and Biotechnology/Institute of Food Science, Pukyong National University)
Park, Jin-Gyu (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
Kim, Jae-Hun (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
Lee, Ju-Woon (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
Byun, Myung-Woo (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
Ahn, Dong-Hyun (Faculty of Food Science and Biotechnology/Institute of Food Science, Pukyong National University)
Publication Information
Food Science and Biotechnology / v.17, no.5, 2008 , pp. 1003-1009 More about this Journal
Abstract
This study was performed to determine the effects of $\gamma$-irradiation on the antiallergic activity of alginate. An alginate aqueous solution was $\gamma$-irradiated at 3, 5, 7, 10, 20, and 100 kGy. First, the molecular weight (Mw) of alginate rapidly decreased as the $\gamma$-irradiation dose increased up to 20 kGy. Then, the antiallergic activity of the $\gamma$-irradiated alginate was measured. Interlukin (IL)-4 cytokine and IgE level were significantly decreased in the $\gamma$-irradiated alginate groups as compared to the control group in vitro. The mice intraperitoneally administered with the $\gamma$-irradiated alginate exhibited lower ovalbumin-specific IgE and IgG1 level in serum than the control mice. Furthermore, the $\gamma$-irradiated alginate suppressed total and ovalbumin-specific IgE secretions in the splenocytes. Increased IL-2 level was observed in the culture supernatants of the splenocytes that were obtained from the mice administerd with the $\gamma$-irradiated alginate, while IL-4 level decreased. The present study indicates that $\gamma$-irradiated alginate can suppress allergy in a mouse allergy model.
Keywords
alginate; antiallergic activity$\gamma$-irradiation;
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