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Effect of Elsholtzia splendens Extracts on the Blood Lipid Profile and Hepatotoxicity of the Mice  

Choi, Eun-Jeong (Plant Resources Research Institute, Duksung Women's University)
Kim, Gun-Hee (Plant Resources Research Institute, Duksung Women's University)
Publication Information
Food Science and Biotechnology / v.17, no.2, 2008 , pp. 413-416 More about this Journal
Abstract
Effects of extracts obtained from the flowers of Elsholtzia splendens on the serum lipid profile and hepatotoxicity in mice were investigated. Female ICR mice were given E. splendens ethanolic extract (ESEs) orally at a dose of 10 or 50 mg/kg BW for 50 days. Significant dose-dependent decreases in triglyceride and low-density lipoprotein (LDL)-cholesterol of serum were observed. In addition, ESEs prolonged the lag-time of LDL oxidation in vitro. In the serum of ICE mice given ESEs orally at 10 and 50 mg/kg BW, the serum levels of aspartate aminotransferase (AST) and lactic dehydrogenase (LDH) increased significantly, while total protein, albumin, creatinine, alanine aminotransferase (ALT), and total bilirubin did not change. Therefore, ESEs may be beneficial to human health, although it has some hepatotoxicity.
Keywords
Elsholtzia splendens; in vivo; hepatotoxicity; lipid profile; low-density lipoprotein (LDL)-oxidation;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
Times Cited By Web Of Science : 3  (Related Records In Web of Science)
Times Cited By SCOPUS : 3
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1 Chang R. Bioactive polysaccharides from traditional Chinese medicine herbs as anticancer adjuvants. J. Altern. Complem. Med. 8: 559-565 (2002)   DOI   ScienceOn
2 Arab L. Epidemiologic challenges in the study of the efficacy and safety of medicinal herbs. Public Health Nutr. 3: 453-457 (2000)
3 Ling H, Lou Y. Total flavones from Elsholtzia blanda reduce infarct size during acute myocardial ischemia by inhibiting myocardial apoptosis in rats. J. Ethnopharmacol. 101: 169-175 (2005)   DOI   ScienceOn
4 Kim DW, Son KH, Chang HW, Bae K, Kang SS, Kim HP. Antiinflammatory activity of Elsholtzia splendens. Arch. Pharm. Res. 26: 232-236 (2003)   DOI
5 Choi EJ, Lee YS, Kim GH. Antioxidative characteristics of extracts from aromatic herb Elsholtzia splendens. Food. Sci. Biotechnol. 16: 489-492 (2007)   과학기술학회마을
6 Puhl H, Waeg G, Esterbauer H. Methods to determine oxidation of low-density lipoproteins. Method Enzymol. 233: 425-441 (1994)   DOI
7 Lau BH. Suppression of LDL oxidation by garlic. J. Nutr. 131: 985S-988S (2001)   DOI
8 Meagher E, Rader DJ. Antioxidant therapy and atherosclerosis: Animal and human studies. Trends Cardiovas. Med. 11: 162-165 (2001)   DOI   ScienceOn
9 Ling H, Lou Y, Wu H, Lou H. Total flavones from Elsholtzia blanda reduce infarct size and improve heart function during acute myocardial infarction by inhibiting myocardial apoptosis in canines. Acta Cardiol. 60: 295-301 (2005)   DOI   ScienceOn
10 Guide for the Care and Use of Laboratory Animals. Institute of Laboratory Animal Resources, Commission on Life Sciences and National Research Council, National Academy Press, Washington DC, USA (1996)
11 Yousef MI, Awad TI, Mohamed EH. Deltamethrin-induced oxidative damage and biochemical alterations in rat and its attenuation by Vitamin E. Toxicology 227: 240-247 (2006)   DOI   ScienceOn
12 Lee SY, Chung MS, Kim MK, Baek HH, Lee MS. Volatile compounds of Elsholtzia splendens. Korean J. Food Sci. Technol. 37: 339-344 (2005)   과학기술학회마을
13 Choi EJ. The prooxidant, rather than antioxidant, acts of daidzein in vivo and in vitro: Daidzein suppresses glutathione metabolism. Eur. J. Pharmacol. 542: 162-169 (2007)
14 Bosutti A, Grassi G, Zanetti M, Aleksova A, Zecchin M, Sinagra G, Biolo G, Guarnieri G. Relation between the plasma levels of LDLcholesterol and the expression of the early marker of inflammation long pentraxin PTX3 and the stress response gene p66(ShcA) in pacemaker-implanted patients. Clin. Exp. Med. 7: 16-23 (2007)   DOI   ScienceOn
15 Choi EJ, Kang EJ, Lee YS, Kim GH. Pro-apoptotic activity of Elsholtzia splendens extract in human breast cancer MDA-MB-453 cells (abstract no. 59). In: Abstracts: 7th International Conference and Exhibition on Nutraceuticals and Functional Foods (Worldnutra 2006). Nov. 5-8, Reno, NV, USA. NRC Institute for Nutrasciences and Health (NRC-INH) (2006)
16 Tiyyagura SR, Smith DA. Standard lipid profile. Clin. Lab. Med. 26: 707-732 (2006)   DOI   ScienceOn
17 Wranicz JK, Cygankiewicz I, Rosiak M, Kula P, Kula K, Zareba W. The relationship between sex hormones and lipid profile in men with coronary artery disease. Int. J. Cardiol. 101: 105-110 (2005)   DOI   ScienceOn
18 Lee KH. Research and future trends in the pharmaceutical development of medicinal herbs from Chinese medicine. Public Health Nutr. 3: 515-522 (2000)
19 Oh JH, Kim EO, Lee SK, Woo MH, Choi SW. Antioxidant activities of the ethanol extract of hamcho (Salicornia herbacea L.) cake prepared by enzymatic treatment. Food. Sci. Biotechnol. 16: 90-98 (2007)   과학기술학회마을
20 Heo J. Dongeubogam (Oriental Medicine). Namsandang, Seoul, Korea. p.1173 (2000)
21 Ahn DK. Illustrated Book of Korean Medicinal Herbs. Kyo-Hak Publishing Co., Seoul, Korea. p.35 (1998)
22 Korantzopoulos P, Kokkoris S. The antioxidant effects of statins may extend beyond atherosclerosis: Potential benefits for atrial fibrillation and heart failure. Atherosclerosis 175: 187 (2004)   DOI   ScienceOn
23 Jeong JH, Lim HB. The chemical composition and biological activities of volatile flavor components of Elsholtzia splendens. Anal. Sci. Technol. 18: 500-510 (2005)
24 Park EJ, Park NS, Park HR, Jin BR, Lee SM. Fruiting body extracts of Paecilomyces tenuipes Ameliorate lipid and antioxidant metabolism in rats fed a high fat-cholesterol diet. Food. Sci. Biotechnol. 15: 710-714 (2006)   과학기술학회마을
25 Ros E. Intestinal absorption of triglyceride and cholesterol. Dietary and pharmacological inhibition to reduce cardiovascular risk. Atherosclerosis 151: 357-379 (2000)   DOI   ScienceOn