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Fruiting Body Extracts of Paecilomyces tenuipes Ameliorate Lipid and Antioxidant Metabolism in Rats Fed a High Fat-Cholesterol Diet  

Park, Eun-Ju (Department of Food and Nutrition, Kyungnam University)
Park, Nam-Sook (Department of Life Science and Environmental Biochemistry, College of Natural Resources and Life Science, Pusan National University)
Park, Hae-Ryong (Division of Food Science and Biotechnology, Kyungnam University)
Jin, Byung-Rae (College of Natural Resources and Life Science, Dong-A University)
Lee, Sang-Mong (Department of Life Science and Environmental Biochemistry, College of Natural Resources and Life Science, Pusan National University)
Publication Information
Food Science and Biotechnology / v.15, no.5, 2006 , pp. 710-714 More about this Journal
Abstract
The present study examined the lipid lowering and antioxidant activity of Paecilomyces tenuipes. Eight week-old male Sprague-Dawley rats were fed one of the three diets, a reference diet without cholesterol addition (NC), a high fat (17 g/ 100 g)-high cholesterol (1 g/100 g) diet (HC) and a HC diet supplemented with 3% P. tenuipes (PT) for 30 days. Total lipid and total cholesterol were reduced significantly by 33 and 37%, respectively, in the PT diet group compared with controls. A similar reduction was found for low density lipoprotein (LDL) cholesterol levels, while plasma high density lipoprotein (HDL) cholesterol and triglyceride (TG) concentrations were not significantly different among groups. Hepatic total lipid and total cholesterol levels, but not hepatic TG levels, were significantly decreased in the PT group compared to the HC group. The administration of P. tenuipes increased the plasma total antioxidant potential and decreased the levels of lipid peroxidation. These results suggest that P. tenuipes exerts significant health benefits through the modulation of physiological functions including a variety of atherogenic lipid profiles and antioxidants in hypercholesterolemia.
Keywords
cholesterol lowering; lipid peroxidation; antioxidant; Paecilomyces tenuipes;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
Times Cited By Web Of Science : 5  (Related Records In Web of Science)
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1 Cho SY. Cultivation and distribution of silkworm dongchunghacho (Paecilomyces japonica). pp. 73-82. In: The Proceeding of the 1st International Symposium on Cordyceps. November 9, National Institute of Agricultural Science and Technology, Suwon, Korea. The Korean Society of Sericultural Science, Seoul, Korea (1999)
2 Shim JS, Chang HR, Min EG, Kim YH, Han YH. Cytotoxicity of Paecilomyces tenuipes against human carcinoma cells, HepG2 and MCF-7 in vitro. Microbiology 29: 170-172 (2001)
3 Cox DA, Cohen ML. Effects of oxidized low-density lipoprotein on vascular contraction and relaxation: clinical and pharmacological implications in atherosclerosis. Pharmacol. Rev. 48: 3-19 (1996)
4 Pritchard KA, Jr, Groszek L, Smalley DM, Sessa WC, Wu M, Villalon P, Wolin MS, Stemerman MB. Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion. Circ. Res. 77: 510-518 (1995)   DOI   ScienceOn
5 Folch J, Lees M, Sloan-Stanley GH. A simple method for isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226: 497-509 (1956)
6 Rice-Evans C, Miller NJ. Total antioxidant status in plasma and body fluids. In: Methods in Enzymology. Academic Press, Inc., New York, NY, USA. pp. 279-293 (1994)
7 Chai YM, Kim MJ, Lim BK, Lee JY, Rhee IK, Lee IS, Rhee SJ. Effects of soluble dietary fiber manufactured from Quercus mongolica on improvement of antioxidative defense system in rats fed high cholesterol diet. Food Sci. Biotechnol. 13: 772-776 (2004)
8 Shim JS, Min EG, Chang HR, Lee CY, Kim SS, Han YH. Cytotoxicity against human cancer cell lines by Paecilomyces tenuipes DUGM 32001. Korean J. Microbiol. 36: 312-315 (2000)   과학기술학회마을
9 Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. New Engl. J. Med. 320: 915-924 (1989)   DOI   ScienceOn
10 Barter PJ, Rye KA. Molecular mechanisms of reverse cholesterol transport. Curr. Opin. Lipidol. 7: 82-87 (1996)   DOI   ScienceOn
11 Klurfeld DM. Dietary fiber-mediated mechanisms in carcinogenesis. Cancer Res. 52: 2055s-2059s (1992)
12 Shim JY, Lee YS, Lim SS, Shin KH, Hyun JE, Kim SY, Lee EB. Pharmacological activities of Paecilomyces japonica, A new type cordyceps sp. Korean J. Pharmacogn. 31: 163-167 (2000)   과학기술학회마을
13 Kim HO, Lee MK, Jeon SM, Choi MS. The effect of supplementation of persimmon leaf extract on lipid and antioxidant metabolism in rats fed a high-cholesterol diet. Nutr. Sci. 6: 141-147 (2003)
14 Park YH, Moon EK, Shin YK, Bae MA, Kim JG, Kim YH. Antitumor acitivity of Paecilomyces japonica is mediated by apoptotic cell death. J. Microbiol. Biotechn. 10: 16-20 (2000)   과학기술학회마을
15 Schmidt K, Li Z, Schubert B, Huang B, Stoyanova S, Hamburger M. Screening of entomopathogenic Deuteromycetes for activities on targets involved in degenerative diseases of the central nervous system. J. Ethnopharmacol. 89: 251-260 (2003)   DOI   ScienceOn
16 Ahotupa M, Mamiemi J, Lehtimaki T, Talvinen K, Raitakari O, Vasankari T, Viikari J, Luoma J, Yla-Herttuala S. Baseline diene conjugation in LDL lipids as a direct measure of in vivo oxidation. Clin. Biochem. 31: 257-261 (1998)   DOI   ScienceOn
17 Kong WS, Kim SH, Park JS, Hahn SJ, Chung IM. Evaluation and selection of antioxidative activities of 80 collected and mated mushroom Strains. Food Sci. Biotechnol. 13: 689-693 (2004)
18 Endo A. The discovery and development of HMG - CoA reductase inhibitors. J. Lipid Res. 33: 1569-1582 (1992)
19 Sung JM, Lee HK, Choi YS, Kim YY, Kim SH, Sung GH. Distribution and taxonomy of entomopathofenic fungal species from Korea. Korean J. Microbiol. 25: 239-252 (1997)   과학기술학회마을
20 Wissler RW. Theories and new horizons in the pathogenesis of atherosclerosis and the mechanisms of clinical effects. Arch. Pathol. Lab. Med. 116: 1281-1291 (1992)
21 Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18: 499-502 (1972)
22 Nam KS, Jo YS, Kim YH, Hyun JW, Kim HW. Cytotoxic activities of acetoxyscirpenediol and ergosterol peroxide from Paecilomyces tenuipes. Life Sci. 69: 229-237 (2001)   DOI   ScienceOn
23 Wald NJ, Law MR. Serum cholesterol and ischemic heart disease. Atherosclerosis 118: S1-S5 (1995)   DOI   ScienceOn
24 Koh JB, Choi MA. Effect of Paecilomyces japonica on lipid metabolism in rats fed high fat diet. J. Korean Soc. Food Sci. Nutr. 32: 238-243 (2003)   과학기술학회마을   DOI
25 Bobek P, Ozdin L, Kuniak L, Hromadova M. Regulation of cholesterol metabolism with dietary addition of oyster mushrooms (Pleurotus ostreatus) in rats with hypercholesterolemia. Cas. Lek. Cesk. 136: 186-190 (1997)
26 Kwon SH, Woo HJ, Han D, Kim MK. Effect of Dried Powders and water extracts of Paecilomyces tenuipes and Cordyceps militaris on lipid metabolism, anti oxidative capacity, and immune status in rats. Korean J. Nutr. 34: 271-284 (2004)