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http://dx.doi.org/10.3839/jabc.2022.029

Antioxidant and anti-inflammatory effects of silymarin  

Park, Hyun-Bin (Department of Biomedical Science, Cheongju University)
Kyeong, Inn-Goo (Department of Biomedical Science, Cheongju University)
Kang, Jung-Hoon (Department of Biomedical Science, Cheongju University)
Publication Information
Journal of Applied Biological Chemistry / v.65, no.3, 2022 , pp. 221-230 More about this Journal
Abstract
We investigated the antioxidant and anti-inflammatory effects of silymarin. The antioxidant activity was evaluated using 1,1-diphenyl-1-picrylhydrazyl radical (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals scavenging assays. Silymarin scavenged 71% of DPPH radicals and 78% of ABTS radicals at a concentration of 1 mg/mL, respectively. Silymarin effectively inhibited the oxidative damage of DNA, and the oxidative modifications of human serum proteins and Cu,Zn-SOD. Also silymarin effectively inhibited H2O2- and LPS-induced cell death as well as the generation of reactive oxygen species and DNA fragmentation by H2O2 and LPS. The results suggested that silymarin might be an effective natural antioxidant and anti-inflammatory material.
Keywords
Anti-inflammatory; Antioxidant; Oxidative modification; Reactive oxygen species; Silymarin;
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