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http://dx.doi.org/10.3839/jabc.2022.027

Comparison of the bioactive compounds and anti-inflammatory effects found in different flower colors from Abeliophyllum distichum Nakai  

Jang, Tae-Won (Department of Pharmaceutical Science, Jungwon University)
Choi, Ji-Soo (NST BIO Co., Ltd.)
Han, So-Yeon (Department of Medicinal Plant Science, Jungwon University)
Park, Hye-Jeong (Department of Medicinal Plant Science, Jungwon University)
Lee, Da-Yoon (Department of Medicinal Plant Science, Jungwon University)
Min, Young-Sil (Department of Pharmaceutical Science, Jungwon University)
Park, Jae-Ho (Department of Pharmaceutical Science, Jungwon University)
Publication Information
Journal of Applied Biological Chemistry / v.65, no.3, 2022 , pp. 203-213 More about this Journal
Abstract
Abeliophyllum distichum (A. distichum, Korean endemic plant) is one genus and one species in the Oleaceae family. According to the color variation of petals and calyx, A. distichum is classified as A. distichum (white flower), A. distichum for. lilacinum (pink flowers), A. distichum for. eburneum (ivory flowers), and Okhwang 1 (golden flowers). In previous studies, bioactivities (antioxidant, anti-inflammatory, and anti-cancer) of A. distichum have been reported. We conducted a comparison of the differences in bioactive compounds and the anti-inflammatory effects on macrophages among four flowers of A. distichum (FAD). The identification and quantification of glycosides were analyzed by HPLC/PDA and LCMS. These results were shown FAD has rutin, hirsutrin, and acteoside. Antioxidant activity of FAD significantly decreased reactive oxygen species. In addition, FAD reduced the expression of pro-inflammatory mediators (nitric oxide, iNOS, and COX-2) in lipopolysaccharide-induced RAW 264.7 cells. For further study, we investigated the regulation of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways. In conclusion, FAD may exert anti-inflammatory effects by suppressing inflammatory mediators via regulations of NF-κB and MAPK signaling pathways. Therefore, these findings suggest that FAD is a potential resource as a preventative or therapeutic agent for inflammation.
Keywords
Abeliophyllum distichum Nakai; Anti-inflammation; Glycoside; Nuclear factor-${\kappa}B$;
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