Browse > Article
http://dx.doi.org/10.3839/jabc.2020.057

Antioxidant and anticoagulant activities of Ganghwa medicinal mugwort (Artemisia princeps Pampanini) extract  

In, Man Jin (Department of Chemical Engineering, Chungwoon University)
Kim, Kang Hyun (Department of Chemical Engineering, Chungwoon University)
Kim, Dong Chung (Department of Chemical Engineering, Chungwoon University)
Publication Information
Journal of Applied Biological Chemistry / v.63, no.4, 2020 , pp. 439-442 More about this Journal
Abstract
In vitro antioxidant and anticoagulant activities of 50% ethanolic extract from Ganghwa medicinal mugwort (Artemisia princeps Pampanini) were investigated. The polyphenol and flavonoid contents of the mugwort extract were 106.9±3.3 and 34.1±0.4 mg/g-extract, respectively. The mugwort extract possessed a potent scavenging activity against radicals and nitrite, reducing power, and lipid peroxidation inhibition activity in a concentration-dependent manner. Also the mugwort extract delayed the plasma coagulation time through the inhibition of common coagulation pathway in a dose-dependent manner.
Keywords
Anticoagulant; Antioxidant; Flavonoid; Medicinal mugwort (Artemisia princeps Pampanini); Polyphenol;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
연도 인용수 순위
1 Jeong CH, Kang ST, Joo OS, Lee SC, Shin YH, Shim KH, Cho SH, Choi SG, Heo HJ (2009) Phenolic content, antioxidant effect and acetylcholinesterase inhibitory activity of Korean commercial green, puer, oolong, and black teas. Korean J Food Preserv 16: 230-237
2 Kim DC (2020) Antioxidative activities of ethanolic extracts of Duzhong (Eucommia ulmoides Oliver) leaf and bark. J Appl Biol Chem 63: 259-265   DOI
3 Lee SO, Lee HJ, Yu MH, Im HG, Lee IS (2005) Total polyphenol contents and antioxidant activities of methanol extracts from vegetables produced in Ullung Island. Korean J Food Sci Technol 37: 233-240
4 Jun HI, Kim YA, Kim YS (2014) Antioxidant activities of Rubus coreanus Miquel and Morus alba L. fruits. Korean Soc Food Sci Nutr 43: 381-388   DOI
5 Arnous A, Makris DP, Kefalas P (2001) Effect of principal polyphenolic components in relation to antioxidant characteristics of aged red wines. J Agric Food Chem 49: 5736-5742   DOI
6 Nishino T, Nagumo T (1992) Anticoagulant and antithrombin activities of oversulfated fucans. Carbohydr Res 229: 355-362   DOI
7 Ryu R, Jung UJ, Kim HJ, Lee W, Bae JS, Park YB, Choi MS (2013) Anticoagulant and antiplatelet activities of Artemisia princeps Pampanini and its bioactive components. Prev Nutr Food Sci 18: 181-187   DOI
8 Zong S, Ji J, Li JL, Yang QH, Ye M (2017) Physicochemical properties and anticoagulant activity of polyphenols derived from Lachnum singerianum. J Food Drug Anal 25: 837-844   DOI
9 Park MS, Nam BM, Chung GY (2012) Taxonomic identity of Gangwha-yak-ssuk. Korean J Pl Taxon 42: 161-166   DOI
10 Choi BB, Lee HJ, Bang SK (2004) Studies on the amino acid, sugar analysis and antioxidant effect of extracts from Artemisia sp. Korean J Food Nutr 17: 86-91
11 Yang HG, Kim HJ, Kim HS, Park SN (2012) Antioxidative and antibacterial activities of Artemisia princeps Pampanini extracts. Korean J Microbiol Biotechnol 40: 250-260   DOI
12 Bang MH, Kim DH, Yoo JS, Lee DY, Song MC, Yang HJ, Jeong TS, Lee KT, Choi MS, Chung HG, Baek NI (2005) Isolation and identification of flavonoids from the aerial parts of Sajabalssuk (Artemisia herba). J Kor Soc Appl Biol Chem 48: 418-420
13 Chang SH, Jung EJ, Park YH, Lim DG, Ko NY, Choi WS, Her E, Kim SH, Choi KD, Bae JH, Kim SH, Kang CD, Han DJ, Kim SC (2009) Anti-inflammatory effects of Artemisia princeps in antigen-stimulated T cells and regulatory T cells. J Pharm Pharmacol 61: 1043-1050   DOI
14 Kwon M, Kim CH, Kim HS, Lee SH, Choi GP, Park UY, You SG, Lee HY (2007) Optimal extract condition for the enhancement of anticancer activities of Artemisia princeps Pampanini. Korean J Med Crop Sci 15: 233-240
15 Ryu SN, Kang SS, Kim JS, Ku BI (2004) Quantitative analysis of eupatilin and jaceosidin in Artemisia herba. Korean J Crop Sci 49: 452-456
16 Davis WB (1947) Determination of flavanones in citrus fruits. Anal Chem 19: 476-478   DOI
17 Kim RJ, Kang MJ, Hwang CR, Jung WJ, Shin JH (2012) Antioxidant and cancer cell growth inhibition activity of five different varieties of Artemisia cultivars in Korea. J Life Sci 22: 844-851   DOI
18 Jung UJ, Baek NI, Chung HG, Bang MH, Yoo JS, Jeong TS, Lee KT, Kang YJ, Lee MK, Kim HJ, Yeo JY, Choi MS (2007) The anti-diabetic effects of ethanol extract from two variants of Artemisia princeps Pampanini in C57BL/KsJ-db/db mice. Food Chem Toxicol 45: 2022-2029   DOI
19 Folin O, Denis W (1912) On phosphotungstic-phosphomolybdic compounds as color reagents. J Biol Chem 12: 239-243   DOI
20 Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C (1999) Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biol Med 26: 1231-1237   DOI
21 Blois MS (1958) Antioxidant determination by the use of a stable free radical. Nature 181: 1199-1200   DOI
22 Gray JI, Dugan Jr LR (1975) Inhibition of N-nitrosamine formation in model food system. J Food Sci 40: 981-985   DOI
23 Oyaizu M (1985) Studies on products of browning reaction: antioxidant activities of products of browning reaction prepared from glucosamine. Jap J Nutr 44: 307-315   DOI
24 Nakatani N, Kikuzaki H (1987) A new antioxidative glucoside isolated from oregano (Origanum vulgare L.). Agric Biol Chem 51: 2727-2732   DOI
25 Fox I, Dawson A, Loynds P, Eisner J, Findlen K, Levin E, Hanson D, Mant T, Wagner J, Maraganore J (1993) Anticoagulant activity of Hirulog, a direct thrombin inhibitor, in humans. Thromb Haemost 69: 157-163   DOI
26 Ardestani A, Yazdanparast R (2007) Antioxidant and free radical scavenging potential of Achillea santolina extracts. Food Chem 104: 21-29   DOI