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http://dx.doi.org/10.3839/jabc.2011.013

Study on the Anti-oxidant and Anti-inflammatory Activities of Sarcocarp and Calyx of Persimmon (Cheongdo Bansi)  

Kim, Hui-Jeong (Product Development Team, Daegu Gyeongbuk Institute for Oriental Medicine Industry)
Park, Tae-Soon (Product Development Team, Daegu Gyeongbuk Institute for Oriental Medicine Industry)
Jung, Mi-Song (Product Development Team, Daegu Gyeongbuk Institute for Oriental Medicine Industry)
Son, Jun-Ho (Product Development Team, Daegu Gyeongbuk Institute for Oriental Medicine Industry)
Publication Information
Journal of Applied Biological Chemistry / v.54, no.2, 2011 , pp. 71-78 More about this Journal
Abstract
Biological activities of sarcocarp and calyx of persimmon (Cheongdo Bansi) were investigated. The electron donating ability of the calyx extract was 91% at a 500 ${\mu}g/mL$ level, which was higher than that of the sarcocarp extract (40%). The superoxide dismutase (SOD)-like activity of calyx extracts was about 22% at a 1,000 ${\mu}g/mL$ level. During the entire experimental period, there was no cytotoxicity found from sarcocarp and calyx up to 50 ${\mu}g/mL$. Our results indicated that sarcocarp and calyx significantly inhibited NO production and iNOS and COX-2 expression accompanied by an attenuation of interleukin (IL)-$1{\beta}$, IL-6, and tumer necrosis factor (TNF)-${\alpha}$ formation in human keratinocyte. These results suggest that sarcocarp and calyx of persimmon may have significant effect on inflammatory factors and can be used as potential anti-inflammatory agents.
Keywords
anti-inflammatory effect; anti-oxidant effect; cytokines; persimmon; persimmon calyx;
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