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http://dx.doi.org/10.4162/nrp.2022.16.S1.S47

Dietary Reference Intake of n-3 polyunsaturated fatty acids for Koreans  

Park, Yongsoon (Department of Food and Nutrition, Hanyang University)
Publication Information
Nutrition Research and Practice / v.16, no.sup1, 2022 , pp. 47-56 More about this Journal
Abstract
This paper examines the process and evidence used to create the Dietary Reference Intake (DRI) of alpha-linolenic acid (ALA) and eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) for Koreans. ALA (18:3n3) is an essential fatty acid, and EPA and DHA are known to have beneficial effects on cardiovascular disease risk and reduction of triglyceride levels. Various international organizations have suggested dietary recommendations for n-3 polyunsaturated fatty acids (PUFAs), including ALA, EPA, and DHA. A DRI for Koreans was established for the first time in 2020, specifically for the adequate intake (AI) of ALA and EPA + DHA. This recommendation was based on the average intake of ALA and EPA + DHA from the Korea National Health and Nutrition Examination Survey 2013-2017. For Korean infants, the AI of ALA and DHA was based on the fatty acid composition of maternal milk. Estimated average requirement and a tolerable upper intake level have not been set for n-3 PUFA due to insufficient evidence. In addition, the intake level of n-3 PUFA for prevention of chronic disease has also not been determined. Future studies and randomized controlled trials are required to establish the UL and to define the level for disease prevention.
Keywords
Alpha-linolenic acid; docosahexaenoic acid; Dietary Reference Intake; eicosapentaenoic acid; n-3 PUFA;
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1 European Food Safety Authority. Dietary reference values for nutrients summary report. Parma: EFSA Supporting Publications; 2017. p.14.
2 Stark KD, Van Elswyk ME, Higgins MR, Weatherford CA, Salem N Jr. Global survey of the omega-3 fatty acids, docosahexaenoic acid and eicosapentaenoic acid in the blood stream of healthy adults. Prog Lipid Res 2016;63:132-52.   DOI
3 Oken E, Radesky JS, Wright RO, Bellinger DC, Amarasiriwardena CJ, Kleinman KP, Hu H, Gillman MW. Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a US cohort. Am J Epidemiol 2008;167:1171-81.   DOI
4 Mozaffarian D, Shi P, Morris JS, Grandjean P, Siscovick DS, Spiegelman D, Willett WC, Rimm EB, Curhan GC, Forman JP. Mercury exposure and risk of hypertension in US men and women in 2 prospective cohorts. Hypertension 2012;60:645-52.   DOI
5 Kang JX, Leaf A. Prevention of fatal cardiac arrhythmias by polyunsaturated fatty acids. Am J Clin Nutr 2000;71:202S-2027S.   DOI
6 Iso H, Kobayashi M, Ishihara J, Sasaki S, Okada K, Kita Y, Kokubo Y, Tsugane S; JPHC Study Group. Intake of fish and n3 fatty acids and risk of coronary heart disease among Japanese: the Japan Public Health Center-Based (JPHC) Study Cohort I. Circulation 2006;113:195-202.   DOI
7 Mozaffarian D, Shi P, Morris JS, Spiegelman D, Grandjean P, Siscovick DS, Willett WC, Rimm EB. Mercury exposure and risk of cardiovascular disease in two U.S. cohorts. N Engl J Med 2011;364:1116-25.   DOI
8 Virtanen JK, Laukkanen JA, Mursu J, Voutilainen S, Tuomainen TP. Serum long-chain n-3 polyunsaturated fatty acids, mercury, and risk of sudden cardiac death in men: a prospective population-based study. PLoS One 2012;7:e41046.   DOI
9 Ministry of Health, Labour and Welfare of Japan. Overview of dietary reference intakes for Japanese. Tokyo: Ministry of Health, Labour and Welfare of Japan; 2020.
10 Harris WS, Park Y, Isley WL. Cardiovascular disease and long-chain omega-3 fatty acids. Curr Opin Lipidol 2003;14:9-14.   DOI
11 Choi KS, Kim ES. A longitudinal study on energy, protein, lipid and lactose intakes of breast-fed infants of lacto-ovo-vegetarian. Korean J Nutr 1997;30:512-9.
12 Park Y, Watkins BA. Endocannabinoids and aging-inflammation, neuroplasticity, mood and pain. Vitam Horm 2021;115:129-72.   DOI
13 Burdge GC, Finnegan YE, Minihane AM, Williams CM, Wootton SA. Effect of altered dietary n-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of [13C]alpha-linolenic acid to longer-chain fatty acids and partitioning towards beta-oxidation in older men. Br J Nutr 2003;90:311-21.   DOI
14 Institute of Medicine. Dietary reference intakes: the essential guide to nutrient requirements. Washington, D.C.: The National Academies Press; 2010.
15 Ahn HS, Um SS. Dietary intakes of infants and young children in Seoul area. J Korean Soc Matern Child Health 2003;7:179-91.   DOI
16 Jones PJH, Papamandjaris AA. Lipids: cellular metabolism. In: Bowman BA, Russell RM, editors. Present Knowledge in Nutrition. Washington, D.C.: International Life Sciences Institute; 2001.
17 Mozaffarian D, Ascherio A, Hu FB, Stampfer MJ, Willett WC, Siscovick DS, Rimm EB. Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men. Circulation 2005;111:157-64.   DOI
18 Ervin RB, Wright JD, Wang CY, Kennedy-Stephenson J. Dietary intake of fats and fatty acids for the United States population: 1999-2000. Adv Data 2004:1-6.
19 Chiuve SE, Rimm EB, Sandhu RK, Bernstein AM, Rexrode KM, Manson JE, Willett WC, Albert CM. Dietary fat quality and risk of sudden cardiac death in women. Am J Clin Nutr 2012;96:498-507.   DOI
20 Siscovick DS, Raghunathan TE, King I, Weinmann S, Wicklund KG, Albright J, Bovbjerg V, Arbogast P, Smith H, Kushi LH, et al. Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. JAMA 1995;274:1363-7.   DOI
21 Manson JE, Cook NR, Lee IM, Christen W, Bassuk SS, Mora S, Gibson H, Albert CM, Gordon D, Copeland T, et al. Marine n-3 fatty acids and prevention of cardiovascular disease and cancer. N Engl J Med 2019;380:23-32.   DOI
22 Shuppan D. The national nutrition survey in Japan, 2001. Health and Nutrition Information Research Committee. Tokyo: Ministry of Health, Labour and Welfare; 2003.
23 Marchioli R, Barzi F, Bomba E, Chieffo C, Di Gregorio D, Di Mascio R, Franzosi MG, Geraci E, Levantesi G, Maggioni AP, et al. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione. Circulation 2002;105:1897-903.   DOI
24 Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, Oikawa S, Sasaki J, Hishida H, Itakura H, et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet 2007;369:1090-8.   DOI
25 Yamagishi K, Iso H, Date C, Fukui M, Wakai K, Kikuchi S, Inaba Y, Tanabe N, Tamakoshi A; Japan Collaborative Cohort Study for Evaluation of Cancer Risk Study Group. Fish, omega-3 polyunsaturated fatty acids, and mortality from cardiovascular diseases in a nationwide community-based cohort of Japanese men and women the JACC (Japan Collaborative Cohort Study for Evaluation of Cancer Risk) Study. J Am Coll Cardiol 2008;52:988-96.   DOI
26 Moon SJ, Lee MJ, Kim JH, Kang JS, Ahn HS, Song SW, Choi MH. A longitudinal study of the total nitrogen, total lipid, and lactose contents in human milk and energy intake of breast-fed infants. Korean J Nutr 1992;25:233-47.
27 Burr ML, Fehily AM, Gilbert JF, Rogers S, Holliday RM, Sweetnam PM, Elwood PC, Deadman NM. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet 1989;2:757-61.
28 Food and Agriculture Organization of United Nations. FAO food and nutrition paper. Fats and fatty acids in human nutrition. Geneva: WHO; 2008. p.1-166.
29 Albert CM, Hennekens CH, O'Donnell CJ, Ajani UA, Carey VJ, Willett WC, Ruskin JN, Manson JE. Fish consumption and risk of sudden cardiac death. JAMA 1998;279:23-8.   DOI
30 Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, Ketchum SB, Doyle RT Jr, Juliano RA, Jiao L, Granowitz C, et al. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. N Engl J Med 2019;380:11-22.   DOI
31 Nicholls SJ, Lincoff AM, Garcia M, Bash D, Ballantyne CM, Barter PJ, Davidson MH, Kastelein JJP, Koenig W, McGuire DK, et al. Effect of high-dose omega-3 fatty acids vs corn oil on major adverse cardiovascular events in patients at high cardiovascular risk: the STRENGTH randomized clinical trial. JAMA 2020;324:2268-80.   DOI
32 Das UN. Essential fatty acids: biochemistry, physiology and pathology. Biotechnol J 2006;1:420-39.   DOI
33 Oken E, Rifas-Shiman SL, Amarasiriwardena C, Jayawardene I, Bellinger DC, Hibbeln JR, Wright RO, Gillman MW. Maternal prenatal fish consumption and cognition in mid childhood: mercury, fatty acids, and selenium. Neurotoxicol Teratol 2016;57:71-8.   DOI
34 de Roos B, Mavrommatis Y, Brouwer IA. Long-chain n-3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease. Br J Pharmacol 2009;158:413-28.   DOI
35 Institute of Medicine. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids. Washington, D.C.: The National Academies Press; 2005.
36 Lim HS, Lee JA, Huh YR, Lee JI. Intakes of energy, protein, lipid and lactose in Korean breast-fed and formula-fed infants. Korean J Nutr 1993;26:325-37.
37 Duan B, Shin JA, Qin Y, Kwon JI, Lee KT. A study on the relationship of fat content in human milk on carotenoids content and fatty acid compositions in Korea. Nutrients 2019;11:2072.   DOI
38 Balk EM, Adams GP, Langberg V, Halladay C, Chung M, Lin L, Robertson S, Yip A, Steele D, Smith BT, et al. Omega-3 fatty acids and cardiovascular disease: an updated systematic review. Evid Rep Technol Assess (Full Rep) 2016:1-1252.
39 Ministry of Health and Welfare, The Korean Nutrition Society. Dietary reference intakes for Koreans 2020. Sejong: Ministry of Health and Welfare; 2020.
40 Kris-Etherton PM, Innis S; Ammerican Dietetic Association; Dietitians of Canada. Position of the American Dietetic Association and Dietitians of Canada: dietary fatty acids. J Am Diet Assoc 2007;107:1599-611.   DOI
41 Bai HS, Lee DH, Ahn HS. Nutrient intakes of infants according to feeding pattern at 2month age. Korean J Nutr 1996;29:77-88.
42 Ahn HS, Jeong JY. Ecological studies of maternal-infant nutrition and feeding in urban low income areas III. Infant's nutrient intakes and growth pattern. Korean J Community Nutr 1998;3:174-89.
43 Kim ES, Lee JS. A longitudinal study on energy, protein, fat and lactose intake of breast-fed infants. Korean J Nutr 2002;35:771-8.