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http://dx.doi.org/10.4162/nrp.2021.15.3.367

Xiang Study: an association of breastmilk composition with maternal body mass index and infant growth during the first 3 month of life  

Peng, Xuyi (H&H Group, Global Research and Technology Center)
Li, Jie (Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University)
Yan, Shuyuan (Child Health Care Center, Changsha Hospital for Maternal and Child Care)
Chen, Juchun (H&H Group, Global Research and Technology Center)
Lane, Jonathan (H&H Group, Global Research and Technology Center)
Malard, Patrice (H&H Group, Global Research and Technology Center)
Liu, Feitong (H&H Group, Global Research and Technology Center)
Publication Information
Nutrition Research and Practice / v.15, no.3, 2021 , pp. 367-381 More about this Journal
Abstract
BACKGROUND/OBJECTIVES: This study aimed to establish a mother and child cohort in the Chinese population, and investigate human breastmilk (HBM) composition and its relationship with maternal body mass index (BMI) and infant growth during the first 3 mon of life. SUBJECTS/METHODS: A total of 101 Chinese mother and infant pairs were included in this prospective cohort. Alterations in the milk macronutrients of Chinese mothers at 1 mon (T1), 2 mon (T2), and 3 mon (T3) lactation were analyzed. HBM fatty acid (FA) profiles were measured by gas chromatography (GC), and HBM proteomic profiling was achieved by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS). RESULTS: During the first 3 mon of lactation (P < 0.05), significant decreases were determined in the levels of total energy, fat, protein, and osteopontin (OPN), as well as ratios of long-chain saturated FA (including C16:0, C22:0 and C24:0), monounsaturated FA (including C16:1), and n-6 poly unsaturated FA (PUFA) (including C20:3n-6 and C20:4n-6, and n-6/n-3). Conversely, butyrate, C6:0 and n-3 PUFA C18:3n-3 (α-linolenic acid, ALA) were significantly increased during the first 3 mon (P < 0.05). HBM proteomic analyses distinguished compositional protein differences over time (P = 0.001). Personalized motherinfant analyses demonstrated that HBM from high BMI mothers presented increased total energy, fat, protein and OPN, and increased content of n-6 PUFA (including C18:3n-6, C20:3n-6 and n-6/n-3 ratio) as compared with low BMI mothers (P < 0.05). Furthermore, BMI of the mothers positively correlated with the head circumference (HC) of infants as well as the specific n-6 PUFA C20:3n-6 over the 3 time points examined. Infant HC was negatively associated with C18:0. CONCLUSION: This study provides additional evidence to the Chinese HBM database, and further knowledge of FA function. It also helps to establish future maternal strategies that support the healthy growth and development of Chinese infants.
Keywords
Humans; milk; breast feeding; body mass index; fatty acids; growth;
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1 Scopesi F, Ciangherotti S, Lantieri PB, Risso D, Bertini I, Campone F, Pedrotti A, Bonacci W, Serra G. Maternal dietary PUFAs intake and human milk content relationships during the first month of lactation. Clin Nutr 2001;20:393-7.   DOI
2 Uauy R, Mena P, Rojas C. Essential fatty acids in early life: structural and functional role. Proc Nutr Soc 2000;59:3-15.   DOI
3 Carlson SE, Rhodes PG, Rao VS, Goldgar DE. Effect of fish oil supplementation on the n-3 fatty acid content of red blood cell membranes in preterm infants. Pediatr Res 1987;21:507-10.   DOI
4 Rudolph MC, Young BE, Lemas DJ, Palmer CE, Hernandez TL, Barbour LA, Friedman JE, Krebs NF, MacLean PS. Early infant adipose deposition is positively associated with the n-6 to n-3 fatty acid ratio in human milk independent of maternal BMI. Int J Obes 2017;41:510-7.   DOI
5 Panagos PG, Vishwanathan R, Penfield-Cyr A, Matthan NR, Shivappa N, Wirth MD, Hebert JR, Sen S. Breastmilk from obese mothers has pro-inflammatory properties and decreased neuroprotective factors. J Perinatol 2016;36:284-90.   DOI
6 Prentice PM, Schoemaker MH, Vervoort J, Hettinga K, Lambers TT, van Tol EA, Acerini CL, Olga L, Petry CJ, Hughes IA, Koulman A, Ong KK, Dunger DB. Human milk short-chain fatty acid composition is associated with adiposity outcomes in infants. J Nutr 2019;149:716-22.   DOI
7 Nishimura RY, Barbieiri P, Castro GS, Jordao AA Jr, Perdona GS, Sartorelli DS. Dietary polyunsaturated fatty acid intake during late pregnancy affects fatty acid composition of mature breast milk. Nutrition 2014;30:685-9.   DOI
8 Marangoni F, Agostoni C, Lammardo AM, Giovannini M, Galli C, Riva E. Polyunsaturated fatty acid concentrations in human hindmilk are stable throughout 12-months of lactation and provide a sustained intake to the infant during exclusive breastfeeding: an Italian study. Br J Nutr 2000;84:103-9.   DOI
9 Butte NF, Garza C, Johnson CA, Smith EO, Nichols BL. Longitudinal changes in milk composition of mothers delivering preterm and term infants. Early Hum Dev 1984;9:153-62.   DOI
10 Agostoni C, Riva E, Scaglioni S, Marangoni F, Radaelli G, Giovannini M. Dietary fats and cholesterol in Italian infants and children. Am J Clin Nutr 2000;72:1384S-1391S.   DOI
11 Puentes AG, Alemany AM, Chisaguano AM, Goyanes RM, Castellote AI, Torres-Espinola FJ, Garcia-Valdes L, Escudero-Marin M, Segura MT, Campoy C, Lopez-Sabater MC. The effect of maternal obesity on breast milk fatty acids and its association with infant growth and cognition-the PREOBE follow-up. Nutrients 2019;9:2154.
12 Makela J, Linderborg K, Niinikoski H, Yang B, Lagstrom H. Breast milk fatty acid composition differs between overweight and normal weight women: the STEPS Study. Eur J Nutr 2013;52:727-35.   DOI
13 Gao Z, Yin J, Zhang J, Ward RE, Martin RJ, Lefevre M, Cefalu WT, Ye J. Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes 2009;58:1509-17.   DOI
14 Sassi M, Arena S, Scaloni A. MALDI-TOF-MS platform for integrated proteomic and peptidomic profiling of milk samples allows rapid detection of food adulterations. J Agric Food Chem 2015;63:6157-71.   DOI
15 Khan S, Hepworth AR, Prime DK, Lai CT, Trengove NJ, Hartmann PE. Variation in fat, lactose, and protein composition in breast milk over 24 hours: associations with infant feeding patterns. J Hum Lact 2013;29:81-9.   DOI
16 Keim SA, Daniels JL, Siega-Riz AM, Herring AH, Dole N, Scheidt PC. Breastfeeding and long-chain polyunsaturated fatty acid intake in the first 4 post-natal months and infant cognitive development: an observational study. Matern Child Nutr 2012;8:471-82.   DOI
17 Lewis ZT, Totten SM, Smilowitz JT, Popovic M, Parker E, Lemay DG, Van Tassell ML, Miller MJ, Jin YS, German JB, Lebrilla CB, Mills DA. Maternal fucosyltransferase 2 status affects the gut bifidobacterial communities of breastfed infants. Microbiome 2015;3:13.   DOI
18 Ashkar S, Weber GF, Panoutsakopoulou V, Sanchirico ME, Jansson M, Zawaideh S, Rittling SR, Denhardt DT, Glimcher MJ, Cantor H. Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity. Science 2000;287:860-4.   DOI
19 Koletzko B, Thiel I, Abiodun PO. The fatty acid composition of human milk in Europe and Africa. J Pediatr 1992;120:S62-70.   DOI
20 Verbeke KA, Boobis AR, Chiodini A, Edwards CA, Franck A, Kleerebezem M, Nauta A, Raes J, van Tol EA, Tuohy KM. Towards microbial fermentation metabolites as markers for health benefits of prebiotics. Nutr Res Rev 2015;28:42-66.   DOI
21 Fujimori M, Franca EL, Fiorin V, Morais TC, Honorio-Franca AC, de Abreu LC. Changes in the biochemical and immunological components of serum and colostrum of overweight and obese mothers. BMC Pregnancy Childbirth 2015;15:166.   DOI
22 Collado MC, Laitinen K, Salminen S, Isolauri E. Maternal weight and excessive weight gain during pregnancy modify the immunomodulatory potential of breast milk. Pediatr Res 2012;72:77-85.   DOI
23 Kim H, Kang S, Jung BM, Yi H, Jung JA, Chang N. Breast milk fatty acid composition and fatty acid intake of lactating mothers in South Korea. Br J Nutr 2017;117:556-61.   DOI
24 Heinig MJ, Nommsen LA, Peerson JM, Lonnerdal B, Dewey KG. Energy and protein intakes of breast-fed and formula-fed infants during the first year of life and their association with growth velocity: the DARLING Study. Am J Clin Nutr 1993;58:152-61.   DOI
25 Ferris AM, Dotts MA, Clark RM, Ezrin M, Jensen RG. Macronutrients in human milk at 2, 12, and 16 weeks postpartum. J Am Diet Assoc 1988;88:694-7.   DOI
26 Jensen GL, Jensen RG. Specialty lipids for infant nutrition. II. Concerns, new developments, and future applications. J Pediatr Gastroenterol Nutr 1992;15:382-94.   DOI
27 Patterson E, Wall R, Fitzgerald GF, Ross RP, Stanton C. Health implications of high dietary omega-6 polyunsaturated Fatty acids. J Nutr Metab 2012;2012:539426.   DOI
28 Comalada M, Bailon E, de Haro O, Lara-Villoslada F, Xaus J, Zarzuelo A, Galvez J. The effects of short-chain fatty acids on colon epithelial proliferation and survival depend on the cellular phenotype. J Cancer Res Clin Oncol 2006;132:487-97.   DOI
29 Grote V, Verduci E, Scaglioni S, Vecchi F, Contarini G, Giovannini M, Koletzko B, Agostoni C; European Childhood Obesity Project. Breast milk composition and infant nutrient intakes during the first 12 months of life. Eur J Clin Nutr 2016;70:250-6.   DOI
30 Okolo SN, VanderJagt TJ, Vu T, VanderJagt TA, VanderJagt DJ, Okonji M, Huang YS, Chuang LT, Onwuanaku C, Glew RH. The fatty acid composition of human milk in northern Nigeria. J Hum Lact 2000;16:28-35.   DOI
31 Wan ZX, Wang XL, Xu L, Geng Q, Zhang Y. Lipid content and fatty acids composition of mature human milk in rural North China. Br J Nutr 2010;103:913-6.   DOI
32 Quinn EA, Largado F, Power M, Kuzawa CW. Predictors of breast milk macronutrient composition in Filipino mothers. Am J Hum Biol 2012;24:533-40.   DOI
33 Neville MC, Allen JC, Archer PC, Casey CE, Seacat J, Keller RP, Lutes V, Rasbach J, Neifert M. Studies in human lactation: milk volume and nutrient composition during weaning and lactogenesis. Am J Clin Nutr 1991;54:81-92.   DOI
34 Allen JC, Keller RP, Archer P, Neville MC. Studies in human lactation: milk composition and daily secretion rates of macronutrients in the first year of lactation. Am J Clin Nutr 1991;54:69-80.   DOI
35 Poston L, Caleyachetty R, Cnattingius S, Corvalan C, Uauy R, Herring S, Gillman MW. Preconceptional and maternal obesity: epidemiology and health consequences. Lancet Diabetes Endocrinol 2016;4:1025-36.   DOI
36 Bruun S, Jacobsen LN, Ze X, Husby S, Ueno HM, Nojiri K, Kobayashi S, Kwon J, Liu X, Yan S, Yang J, Zachariassen G, Chen L, Zhou W, Christensen B, Sorensen ES. Osteopontin levels in human milk vary across countries and within lactation period: data from a multicenter study. J Pediatr Gastroenterol Nutr 2018;67:250-6.   DOI
37 Chisaguano AM, Lozano B, Molto-Puigmarti C, Castellote AI, Rafecas M, Lopez-Sabater MC. Elaidic acid, vaccenic acid and rumenic acid (c9,t11-CLA) determination in human plasma phospholipids and human milk by fast gas chromatography. Anal Methods 2013;5:1264.   DOI
38 Gibb S, Strimmer K. MALDIquant: a versatile R package for the analysis of mass spectrometry data. Bioinformatics 2012;28:2270-1.   DOI
39 Nommsen LA, Lovelady CA, Heinig MJ, Lonnerdal B, Dewey KG. Determinants of energy, protein, lipid, and lactose concentrations in human milk during the first 12 mo of lactation: the DARLING Study. Am J Clin Nutr 1991;53:457-65.   DOI
40 Lonnerdal B, Erdmann P, Thakkar SK, Sauser J, Destaillats F. Longitudinal evolution of true protein, amino acids and bioactive proteins in breast milk: a developmental perspective. J Nutr Biochem 2017;41:1-11.   DOI
41 Prentice P, Acerini CL, Eleftheriou A, Hughes IA, Ong KK, Dunger DB. Cohort profile: the Cambridge Baby Growth Study (CBGS). Int J Epidemiol 2016;45:35.a-g.   DOI
42 Popkin BM, Horton S, Kim S, Mahal A, Shuigao J. Trends in diet, nutritional status, and diet-related noncommunicable diseases in China and India: the economic costs of the nutrition transition. Nutr Rev 2001;59:379-90.   DOI
43 Glaser C, Lattka E, Rzehak P, Steer C, Koletzko B. Genetic variation in polyunsaturated fatty acid metabolism and its potential relevance for human development and health. Matern Child Nutr 2011;7 Suppl 2:27-40.
44 Koletzko B, Boey CC, Campoy C, Carlson SE, Chang N, Guillermo-Tuazon MA, Joshi S, Prell C, Quak SH, Sjarif DR, Su Y, Supapannachart S, Yamashiro Y, Osendarp SJ. Current information and Asian perspectives on long-chain polyunsaturated fatty acids in pregnancy, lactation, and infancy: systematic review and practice recommendations from an early nutrition academy workshop. Ann Nutr Metab 2014;65:49-80.   DOI
45 Schack L, Lange A, Kelsen J, Agnholt J, Christensen B, Petersen TE, Sorensen ES. Considerable variation in the concentration of osteopontin in human milk, bovine milk, and infant formulas. J Dairy Sci 2009;92:5378-85.   DOI
46 Lanigan J, Singhal A. Early nutrition and long-term health: a practical approach. Proc Nutr Soc 2009;68:422-9.   DOI
47 Ziegler EE. Growth of breast-fed and formula-fed infants. Nestle Nutr Workshop Ser Pediatr Program 2006;58:51-9, discussion 59-63.   DOI
48 Ong KK, Emmett P, Northstone K, Golding J, Rogers I, Ness AR, Wells JC, Dunger DB. Infancy weight gain predicts childhood body fat and age at menarche in girls. J Clin Endocrinol Metab 2009;94:1527-32.   DOI
49 Belkind-Gerson J, Carreon-Rodriguez A, Contreras-Ochoa CO, Estrada-Mondaca S, Parra-Cabrera MS. Fatty acids and neurodevelopment. J Pediatr Gastroenterol Nutr 2008;47 Suppl 1:S7-9.   DOI
50 Martin CR, Ling PR, Blackburn GL. Review of infant feeding: key features of breast milk and infant formula. Nutrients 2016;8:279.   DOI