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http://dx.doi.org/10.4162/nrp.2018.12.2.160

Associations of serum levels of vitamins A, C, and E with the risk of cognitive impairment among elderly Koreans  

Kim, Sung Hee (Department of Clinical Nutrition, School of Public Health, Dongduk Women's University)
Park, Yeong Mi (Department of Foods and Nutrition, College of Natural Sciences, Dongduk Women's University)
Choi, Bo Youl (Department of Preventive Medicine, College of Medicine, Hanyang University)
Kim, Mi Kyung (Department of Preventive Medicine, College of Medicine, Hanyang University)
Roh, Sungwon (Department of Psychiatry, College of Medicine, Hanyang University)
Kim, Kyunga (Statistics and Data Center, Research Institute for Future Medicine, Samsung Medical Center)
Yang, Yoon Jung (Department of Foods and Nutrition, College of Natural Sciences, Dongduk Women's University)
Publication Information
Nutrition Research and Practice / v.12, no.2, 2018 , pp. 160-165 More about this Journal
Abstract
BACKGROUND/OBJECTIVES: Korea is quickly becoming an aged society. Dementia is also becoming a vital public health problem in Korea. Cognitive impairment as a pre-stage of dementia shares most risk factors for dementia. The aim of the present study was to determine associations of serum levels of vitamins A, C, and E with the risk of cognitive impairment among elderly Koreans. SUBJECTS/METHODS: In this cross-sectional study, a total of 230 participants aged 60-79 years from Yangpyeong cohort were included. Cognitive function was assessed by the Korean version of the Mini-Mental State Examination for Dementia Screening. The logistic multivariable regression model was applied to determine the effect of serum vitamins A, C, and E on the risk of cognitive impairment. RESULTS: There was no significant association between the risk of cognitive impairment and serum levels of vitamin A and vitamin C. There was a significant odd ratio when the second tertile group of beta-gamma tocopherol level was compared to the first tertile group [odds ratio (OR) = 0.37, 95% confidence interval (CI) = 0.14-0.98, P for trend = 0.051]. In subgroup analyses, there were significant negative associations between beta-gamma tocopherol level and the risk of cognitive impairment in men (OR = 0.17, 95% CI = 0.03-0.87, P for trend = 0.028), non-drinkers or former drinkers (OR = 0.13, 95% CI = 0.02-0.66, P for trend = 0.025), and non-smokers or former smokers (OR = 0.27, 95% CI = 0.09-0.82, P for trend = 0.017). CONCLUSION: Serum beta-gamma tocopherol levels tended to be inversely associated with the risk of cognitive impairment. Further prospective large-scaled studies are needed to examine this association.
Keywords
Dementia; cognition; vitamin A; ascorbic acid; vitamin E;
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