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http://dx.doi.org/10.4162/nrp.2017.11.4.327

Effects of folic acid supplementation on serum homocysteine levels, lipid profiles, and vascular parameters in post-menopausal Korean women with type 2 diabetes mellitus  

Vijayakumar, Aswathy (Department of Nutritional Science and Food Management, Ewha Womans University)
Kim, Eun-kyung (Department of Nutritional Science and Food Management, Ewha Womans University)
Kim, Hyesook (Department of Nutritional Science and Food Management, Ewha Womans University)
Choi, Young Ju (Huh's Diabetes Clinics & 21C Diabetes and Vascular Research Institute)
Huh, Kap Bum (Huh's Diabetes Clinics & 21C Diabetes and Vascular Research Institute)
Chang, Namsoo (Department of Nutritional Science and Food Management, Ewha Womans University)
Publication Information
Nutrition Research and Practice / v.11, no.4, 2017 , pp. 327-333 More about this Journal
Abstract
BACKGROUND/OBJECTIVES: Complications of diabetes, such as cardiovascular disease, are associated with increased mortality among type 2 diabetes mellitus patients. Homocysteine has been recently identified as a predictor of cardiovascular disease-related complications in diabetes. We investigated whether or not supplementation with folic acid tablets can lower homocysteine levels and improve parameters related with vascular complications. SUBJECTS/METHODS: We conducted a non-randomized 8-week trial involving postmenopausal diabetic women (n = 25) supplemented with $800{\mu}g$ of folic acid ($400{\mu}g$ twice a day) daily. Subjects' serum levels of folate, homocysteine, and vitamin $B_{12}$ were measured, along with vascular function and brachial-ankle pulse wave velocity. RESULTS: Folic acid supplementation significantly increased serum folate levels (P < 0.0001), reduced homocysteine levels (P < 0.0001), and increased vitamin $B_{12}$ levels (P = 0.0063). There were significant decreases in low-density lipoprotein cholesterol levels as well as the ratios of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol and total cholesterol to high-density lipoprotein cholesterol. Brachial-ankle pulse wave velocities were not altered by supplementation. Changes in serum vitamin $B_{12}$ after folic acid supplementation were negatively correlated with changes in brachial-ankle pulse wave velocity. CONCLUSIONS: In this study on postmenopausal Korean women with type 2 diabetes mellitus, folic acid supplementation reduced serum homocysteine levels, increased serum folate and vitamin $B_{12}$ levels, and lowered lipid parameters.
Keywords
Folic acid; vitamin $B_{12}$; LDL cholesterol; pulse wave velocity;
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