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http://dx.doi.org/10.4162/nrp.2017.11.2.114

Association of serum carotenoid, retinol, and tocopherol concentrations with the progression of Parkinson's Disease  

Kim, Ji Hyun (Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine)
Hwang, Jinah (Department of Food and Nutrition, College of Natural Sciences, Myongji University)
Shim, Eugene (Department of Food and Nutrition, Soongeui Women's College)
Chung, Eun-Jung (Division of General Studies, Kangnam University)
Jang, Sung Hee (Division of Diet Research, Institute of Food & Culture, Pulmuone)
Koh, Seong-Beom (Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine)
Publication Information
Nutrition Research and Practice / v.11, no.2, 2017 , pp. 114-120 More about this Journal
Abstract
BACKGROUND/OBJECTIVES: A pivotal role of oxidative stress has been emphasized in the pathogenesis as well as in the disease progression of Parkinson's disease (PD). We aimed at investigating serum levels of antioxidant vitamins and elucidating whether they could be associated with the pathogenesis and progression of PD. MATERIALS/METHODS: Serum levels of retinol, ${\alpha}$- and ${\gamma}$-tocopherols, ${\alpha}$- and ${\beta}$-carotenes, lutein, lycopene, zeaxanthin and ${\beta}$-cryptoxanthin were measured and compared between 104 patients with idiopathic PD and 52 healthy controls matched for age and gender. In order to examine the relationship between antioxidant vitamins and the disease progression, multiple group comparisons were performed among the early PD (Hoehn and Yahr stage I and II, N = 47), advanced PD (stage III and IV, N = 57) and control groups. Separate correlation analyses were performed between the measured antioxidant vitamins and clinical variables, such as Hoehn and Yahr stage and Unified Parkinson's Disease Rating Scale (UPDRS) motor score. RESULTS: Compared to controls, PD patients had lower levels of ${\alpha}$- and ${\beta}$-carotenes and lycopene. ${\alpha}$-carotene, ${\beta}$-carotene and lycopene levels were significantly reduced in advanced PD patients relative to early PD patients and were negatively correlated with Hoehn and Yahr stage and UPDRS motor score in PD patients. No significant differences were found in serum levels of retinol, ${\alpha}$- and ${\gamma}$-tocopherols, and other carotenoids between PD patients and controls. No significant correlations were found between these vitamin levels and clinical variables in PD patients. CONCLUSTIONS: We found that serum levels of some carotenoids, ${\alpha}$-carotene, ${\beta}$-carotene and lycopene, were lower in PD patients, and that these carotenoids inversely correlated with clinical variables representing disease progression. Our findings suggest that decreases in serum ${\alpha}$-carotene, ${\beta}$-carotene and lycopene may be associated with the pathogenesis as well as progression of PD.
Keywords
Parkinson disease; oxidative stress; carotenoids; disease progression;
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1 Dexter DT, Ward RJ, Wells FR, Daniel SE, Lees AJ, Peters TJ, Jenner P, Marsden CD. Alpha-tocopherol levels in brain are not altered in Parkinson's disease. Ann Neurol 1992;32:591-3.   DOI
2 Jimenez-Jimenez FJ, de Bustos F, Molina JA, Benito-Leon J, Tallon-Barranco A, Gasalla T, Orti-Pareja M, Guillamon F, Rubio JC, Arenas J, Enriquez-de-Salamanca R. Cerebrospinal fluid levels of alpha-tocopherol (vitamin E) in Alzheimer's disease. J Neural Transm (Vienna) 1997;104:703-10.   DOI
3 Tohgi H, Abe T, Saheki M, Hamato F, Sasaki K, Takahashi S. Reduced and oxidized forms of glutathione and ${\alpha}$-tocopherol in the cerebrospinal fluid of parkinsonian patients: comparison between before and after L-dopa treatment. Neurosci Lett 1995;184:21-4.   DOI
4 Fiedor J, Burda K. Potential role of carotenoids as antioxidants in human health and disease. Nutrients 2014;6:466-88.   DOI
5 Ulatowski L, Parker R, Warrier G, Sultana R, Butterfield DA, Manor D. Vitamin E is essential for Purkinje neuron integrity. Neuroscience 2014;260:120-9.   DOI
6 de Rijk MC, Breteler MM, den Breeijen JH, Launer LJ, Grobbee DE, van der Meche FG, Hofman A. Dietary antioxidants and Parkinson disease. The Rotterdam study. Arch Neurol 1997;54:762-5.   DOI
7 Golbe LI, Farrell TM, Davis PH. Follow-up study of early-life protective and risk factors in Parkinson's disease. Mov Disord 1990;5:66-70.   DOI
8 Miyake Y, Fukushima W, Tanaka K, Sasaki S, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M; Fukuoka Kinki Parkinson's Disease Study Group. Dietary intake of antioxidant vitamins and risk of Parkinson's disease: a case-control study in Japan. Eur J Neurol 2011;18:106-13.   DOI
9 Zhang SM, Hernan MA, Chen H, Spiegelman D, Willett WC, Ascherio A. Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk. Neurology 2002;59:1161-9.   DOI
10 Logroscino G, Marder K, Cote L, Tang MX, Shea S, Mayeux R. Dietary lipids and antioxidants in Parkinson's disease: a population-based, case-control study. Ann Neurol 1996;39:89-94.   DOI
11 Johnson CC, Gorell JM, Rybicki BA, Sanders K, Peterson EL. Adult nutrient intake as a risk factor for Parkinson's disease. Int J Epidemiol 1999;28:1102-9.   DOI
12 Morens DM, Grandinetti A, Waslien CI, Park CB, Ross GW, White LR. Case-control study of idiopathic Parkinson's disease and dietary vitamin E intake. Neurology 1996;46:1270-4.   DOI
13 Hellenbrand W, Boeing H, Robra BP, Seidler A, Vieregge P, Nischan P, Joerg J, Oertel WH, Schneider E, Ulm G. Diet and Parkinson's disease. II: a possible role for the past intake of specific nutrients. Results from a self-administered food-frequency questionnaire in a case-control study. Neurology 1996;47:644-50.   DOI
14 Nicoletti G, Crescibene L, Scornaienchi M, Bastone L, Bagala A, Napoli ID, Caracciolo M, Quattrone A. Plasma levels of vitamin E in Parkinson's disease. Arch Gerontol Geriatr 2001;33:7-12.
15 Sohmiya M, Tanaka M, Tak NW, Yanagisawa M, Tanino Y, Suzuki Y, Okamoto K, Yamamoto Y. Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease. J Neurol Sci 2004;223:161-6.   DOI
16 Ahlskog JE, Uitti RJ, Low PA, Tyce GM, Nickander KK, Petersen RC, Kokmen E. No evidence for systemic oxidant stress in Parkinson's or Alzheimer's disease. Mov Disord 1995;10:566-73.   DOI
17 Sudha K, Rao AV, Rao S, Rao A. Free radical toxicity and antioxidants in Parkinson's disease. Neurol India 2003;51:60-2.
18 Fernandez-Calle P, Molina JA, Jimenez-Jimenez FJ, Vazquez A, Pondal M, Garcia-Ruiz PJ, Urra DG, Domingo J, Codoceo R. Serum levels of alpha-tocopherol (vitamin E) in Parkinson's disease. Neurology 1992;42:1064-6.   DOI
19 Foy CJ, Passmore AP, Vahidassr MD, Young IS, Lawson JT. Plasma chain-breaking antioxidants in Alzheimer's disease, vascular dementia and Parkinson's disease. QJM 1999;92:39-45.   DOI
20 Anderson C, Checkoway H, Franklin GM, Beresford S, Smith-Weller T, Swanson PD. Dietary factors in Parkinson's disease: the role of food groups and specific foods. Mov Disord 1999;14:21-7.   DOI
21 Buhmann C, Arlt S, Kontush A, Moller-Bertram T, Sperber S, Oechsner M, Stuerenburg HJ, Beisiegel U. Plasma and CSF markers of oxidative stress are increased in Parkinson's disease and influenced by antiparkinsonian medication. Neurobiol Dis 2004;15:160-70.   DOI
22 Jimenez-Jimenez FJ, Molina JA, Fernandez-Calle P, Vazquez A, Cabrera-Valdivia F, Catalan MJ, Garcia-Albea E, Bermejo F, Codoceo R. Serum levels of beta-carotene and other carotenoids in Parkinson's disease. Neurosci Lett 1993;157:103-6.   DOI
23 Verhage BA, Aben KK, Straatman H, Verbeek AL, Beaty TH, Kiemeney LA. Spouse controls in family case-control studies: a methodological consideration. Fam Cancer 2003;2:101-8.   DOI
24 Smith DS, Fillenbaum GG. Comparison of spouse and nonkin controls: the experience of the Consortium to Establish a Registry for Alzheimer's disease (CERAD). Aging (Milano) 1994;6:151-7.
25 Gelb DJ, Oliver E, Gilman S. Diagnostic criteria for Parkinson disease. Arch Neurol 1999;56:33-9.   DOI
26 Hoehn MM, Yahr MD. Parkinsonism: onset, progression and mortality. Neurology 1967;17:427-42.   DOI
27 Yeum KJ, Ahn SH, Rupp de Paiva SA, Lee-Kim YC, Krinsky NI, Russell RM. Correlation between carotenoid concentrations in serum and normal breast adipose tissue of women with benign breast tumor or breast cancer. J Nutr 1998;128:1920-6.   DOI
28 Sopher BL, Fukuchi K, Kavanagh TJ, Furlong CE, Martin GM. Neurodegenerative mechanisms in Alzheimer disease. A role for oxidative damage in amyloid beta protein precursor-mediated cell death. Mol Chem Neuropathol 1996;29:153-68.   DOI
29 Kontush K, Schekatolina S. Vitamin E in neurodegenerative disorders: Alzheimer's disease. Ann N Y Acad Sci 2004;1031:249-62.   DOI
30 Delanty N, Dichter MA. Antioxidant therapy in neurologic disease. Arch Neurol 2000;57:1265-70.
31 Johnson EJ, Vishwanathan R, Johnson MA, Hausman DB, Davey A, Scott TM, Green RC, Miller LS, Gearing M, Woodard J, Nelson PT, Chung HY, Schalch W, Wittwer J, Poon LW. Relationship between serum and brain carotenoids, alpha-tocopherol, and retinol concentrations and cognitive performance in the oldest old from the Georgia Centenarian Study. J Aging Res 2013;2013:951786.
32 Al-Delaimy WK, Ferrari P, Slimani N, Pala V, Johansson I, Nilsson S, Mattisson I, Wirfalt E, Galasso R, Palli D, Vineis P, Tumino R, Dorronsoro M, Pera G, Ocke MC, Bueno-de-Mesquita HB, Overvad K, Chirlaque M, Trichopoulou A, Naska A, Tjonneland A, Olsen A, Lund E, Alsaker EH, Barricarte A, Kesse E, Boutron-Ruault MC, Clavel-Chapelon F, Key TJ, Spencer E, Bingham S, Welch AA, Sanchez-Perez MJ, Nagel G, Linseisen J, Quiros JR, Peeters PH, van Gils CH, Boeing H, van Kappel AL, Steghens JP, Riboli E. Plasma carotenoids as biomarkers of intake of fruits and vegetables: individual-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC). Eur J Clin Nutr 2005;59:1387-96.   DOI
33 Al-Delaimy WK, Slimani N, Ferrari P, Key T, Spencer E, Johansson I, Johansson G, Mattisson I, Wirfalt E, Sieri S, Agudo A, Celentano E, Palli D, Sacerdote C, Tumino R, Dorronsoro M, Ocke MC, Bueno-De-Mesquita HB, Overvad K, Chirlaque MD, Trichopoulou A, Naska A, Tjonneland A, Olsen A, Lund E, Skeie G, Ardanaz E, Kesse E, Boutron-Ruault MC, Clavel-Chapelon F, Bingham S, Welch AA, Martinez-Garcia C, Nagel G, Linseisen J, Quiros JR, Peeters PH, van Gils CH, Boeing H, van Kappel AL, Steghens JP, Riboli E. Plasma carotenoids as biomarkers of intake of fruits and vegetables: ecological-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC). Eur J Clin Nutr 2005;59:1397-408.   DOI
34 Borrelli E, Chambon P. Control of transcription and neurological diseases. Mol Psychiatry 1999;4:112-4.   DOI
35 Tafti M, Ghyselinck NB. Functional implication of the vitamin A signaling pathway in the brain. Arch Neurol 2007;64:1706-11.   DOI
36 Ascherio A, Stampfer MJ, Colditz GA, Rimm EB, Litin L, Willett WC. Correlations of vitamin A and E intakes with the plasma concentrations of carotenoids and tocopherols among American men and women. J Nutr 1992;122:1792-801.   DOI
37 Goodman DS. Overview of current knowledge of metabolism of vitamin A and carotenoids. J Natl Cancer Inst 1984;73:1375-9.
38 Di Mascio P, Murphy ME, Sies H. Antioxidant defense systems: the role of carotenoids, tocopherols, and thiols. Am J Clin Nutr 1991;53:194S-200S.   DOI
39 Martini MC, Campbell DR, Gross MD, Grandits GA, Potter JD, Slavin JL. Plasma carotenoids as biomarkers of vegetable intake: the University of Minnesota Cancer Prevention Research Unit Feeding Studies. Cancer Epidemiol Biomarkers Prev 1995;4:491-6.
40 Scheider WL, Hershey LA, Vena JE, Holmlund T, Marshall JR, Freudenheim JL. Dietary antioxidants and other dietary factors in the etiology of Parkinson's disease. Mov Disord 1997;12:190-6.   DOI
41 Anglade P, Vyas S, Hirsch EC, Agid Y. Apoptosis in dopaminergic neurons of the human substantia nigra during normal aging. Histol Histopathol 1997;12:603-10.
42 Niki E. Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence. Free Radic Biol Med 2014;66:3-12.   DOI
43 Herrera E, Barbas C. Vitamin E: action, metabolism and perspectives. J Physiol Biochem 2001;57:43-56.   DOI
44 Stahl W, Sies H. Antioxidant activity of carotenoids. Mol Aspects Med 2003;24:345-51.   DOI
45 Pappert EJ, Tangney CC, Goetz CG, Ling ZD, Lipton JW, Stebbins GT, Carvey PM. Alpha-tocopherol in the ventricular cerebrospinal fluid of Parkinson's disease patients: dose-response study and correlations with plasma levels. Neurology 1996;47:1037-42.   DOI
46 de Rijk MC, Breteler MM, Graveland GA, Ott A, Grobbee DE, van der Meche FG, Hofman A. Prevalence of Parkinson's disease in the elderly: the Rotterdam study. Neurology 1995;45:2143-6.   DOI
47 Kim HS, Lee KS, Bae HJ, Koh IS, Chang SH, Im DH, Heo JH. Changes in length of stay for neurological geriatric diseases in Korea between 2003 and 2007. J Clin Neurol 2011;7:148-55.   DOI
48 Kalia LV, Lang AE. Parkinson's disease. Lancet 2015;386:896-912.   DOI
49 Jenner P, Olanow CW. Oxidative stress and the pathogenesis of Parkinson's disease. Neurology 1996;47:S161-70.   DOI
50 Craft NE, Haitema TB, Garnett KM, Fitch KA, Dorey CK. Carotenoid, tocopherol, and retinol concentrations in elderly human brain. J Nutr Health Aging 2004;8:156-62.