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http://dx.doi.org/10.4162/nrp.2013.7.3.216

Intake and blood concentrations of folate and their association with health-related behaviors in Korean college students  

Jang, Han-Byul (Department of Food and Nutrition, Chungbuk National University)
Han, Young-Hee (Department of Food and Nutrition, Chungbuk National University)
Piyathilake, Chandrika J. (Department of Nutrition Sciences, University of Alabama at Birmingham)
Kim, Heon (Department of Preventive Medicine and Medical Research Institute, Chungbuk National University)
Hyun, Taisun (Department of Food and Nutrition, Chungbuk National University)
Publication Information
Nutrition Research and Practice / v.7, no.3, 2013 , pp. 216-223 More about this Journal
Abstract
The purpose of this study is to assess folate intake, and serum and red blood cell (RBC) folate concentrations, and investigate the association between folate status and health-related behaviors among Korean college students. A total of 169 students, aged between 18 and 27 years, participated in this study. Dietary intake data were collected by trained interviewers using a 24-hour recall method for three non-consecutive days in 2009. Information on health-related behaviors was obtained by a self-administered questionnaire. Serum and RBC folate concentrations were measured by microbiological assay. The average intakes of folate were $456{\mu}gDFE$ and $347{\mu}gDFE$ in male and female students, respectively. While the average serum folate concentration was significantly lower in male students (8.9 ng/mL) compared to female students (12.5 ng/mL), RBC concentrations were not significantly different between male (398.6 ng/mL) and female students (405.3 ng/mL). In male students, low serum folate concentrations were associated with total folate intake less than the Estimated Average Requirement, non-use of folic acid supplements, smoking, alcohol drinking at least once a week and low physical activity. In female students, low serum folate concentrations were associated with smoking and alcohol drinking at least two drinks at a time and BMI ${\geq}25$. Alcohol drinking and low physical activity were also associated with low RBC folate concentrations in both male and female students. In order to improve folate nutritional status of college students, the practice of desirable health-related behaviors, such as non-smoking, moderate alcohol drinking, regular physical activity, and maintenance of healthy BMI should be encouraged along with consumption of folate-rich foods and supplements.
Keywords
Folate intake; serum folate; RBC folate; health-related behaviors; college students;
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1 Wallingford JB, Niswander LA, Shaw GM, Finnell RH. The continuing challenge of understanding, preventing, and treating neural tube defects. Science. 2013;339:1222002.   DOI   ScienceOn
2 Kalin SR, Rimm EB. Folate and vascular disease: epidemiological perspective. In: Bailey LB, editor. Folate in Health and Disease. 2nd ed. Boca Raton, FL: CRC press; 2010. p.263-90.
3 Chen J, Xu X, Liu A, Ulrich CM. Folate and cancer: epidemiological perspective. In: Bailey LB, editor. Folate in Health and Disease. 2nd ed. Boca Raton, FL: CRC Press; 2010. p.205-33.
4 Durga J, van Boxtel MP, Schouten EG, Kok FJ, Jolles J, Katan MB, Verhoef P. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007;369:208-16.   DOI   ScienceOn
5 Herrmann M, Peter Schmidt J, Umanskaya N, Wagner A, Taban- Shomal O, Widmann T, Colaianni G, Wildemann B, Herrmann W. The role of hyperhomocysteinemia as well as folate, vitamin B(6) and B(12) deficiencies in osteoporosis: a systematic review. Clin Chem Lab Med 2007;45:1621-32.
6 Herbert V. The 1986 Herman award lecture. Nutrition science as a continually unfolding story: the folate and vitamin B-12 paradigm. Am J Clin Nutr 1987;46:387-402.   DOI
7 Institute of Medicine (US). Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic acid, Biotin, and Choline. Washington, D.C.: National Academies Press; 1998. p.196-305.
8 Daly LE, Kirke PN, Molloy A, Weir DG, Scott JM. Folate levels and neural tube defects. Implications for prevention. JAMA 1995;274:1698-702.   DOI   ScienceOn
9 Hendricks KM, Herbold NH. Diet, activity, and other healthrelated behaviors in college-age women. Nutr Rev 1998;56: 65-75.
10 Hwang JH, Lee HM. A study on lifestyles, dietary habits, nutrition knowledge and dietary behaviors of male university students according to residence type. Korean J Community Nutr 2007;12:381-95.
11 Jang HB, Lee HY, Han YH, Song J, Kim KN, Hyun T. Changes in food and nutrient intakes of college students between 1999 and 2009. Korean J Community Nutr 2011;16:324-36.   DOI
12 Chen KJ, Pan WH, Lin YC, Lin BF. Trends in folate status in the Taiwanese population aged 19 years and older from the Nutrition and Health Survey in Taiwan 1993-1996 to 2005-2008. Asia Pac J Clin Nutr 2011;20:275-82.
13 Jacques PF, Sulsky S, Hartz SC, Russell RM. Moderate alcohol intake and nutritional status in nonalcoholic elderly subjects. Am J Clin Nutr 1989;50:875-83.   DOI
14 Piyathilake CJ, Macaluso M, Hine RJ, Richards EW, Krumdieck CL. Local and systemic effects of cigarette smoking on folate and vitamin B-12. Am J Clin Nutr 1994;60:559-66.   DOI
15 Mojtabai R. Body mass index and serum folate in childbearing age women. Eur J Epidemiol 2004;19:1029-36.   DOI   ScienceOn
16 Hatzis CM, Bertsias GK, Linardakis M, Scott JM, Kafatos AG. Dietary and other lifestyle correlates of serum folate concentrations in a healthy adult population in Crete, Greece: a crosssectional study. Nutr J 2006;5:5.   DOI   ScienceOn
17 Thuesen BH, Husemoen LL, Ovesen L, Jørgensen T, Fenger M, Linneberg A. Lifestyle and genetic determinants of folate and vitamin B12 levels in a general adult population. Br J Nutr 2010;103:1195-204.
18 Hyun TS, Han YH, Lim EY. Blood folate level determined by a microplate reader and folate intake measured by a weighted food record. Korean J Community Nutr 1999;4:512-20.
19 Gall S, Seal J, Taylor R, Dwyer T, Venn A. Folate status and socio-demographic predictors of folate status, among a national cohort of women aged 26-36 in Australia, 2004-2006. Aust N Z J Public Health 2012;36:421-6.   DOI   ScienceOn
20 Korean Nutrition Society. Food Values. Seoul: Korean Nutrition Society; 2009.
21 Hao L, Ma J, Stampfer MJ, Ren A, Tian Y, Tang Y, Willett WC, Li Z. Geographical, seasonal and gender differences in folate status among Chinese adults. J Nutr 2003;133:3630-5.   DOI
22 Hinds HE, Johnson AA, Webb MC, Graham AP. Iron, folate, and vitamin B12 status in the elderly by gender and ethnicity. J Natl Med Assoc 2011;103:870-7.   DOI
23 Lim HS, Heo YR. Plasma total homocysteine, folate, and vitamin B12 status in Korean adults. J Nutr Sci Vitaminol (Tokyo) 2002;48:290-7.   DOI   ScienceOn
24 Han YH, Yon M, Hyun TH. Folate intake estimated with an updated database and its association to blood folate and homocysteine in Korean college students. Eur J Clin Nutr 2005;59: 246-54.   DOI   ScienceOn
25 Park JY, Vollset SE, Melse-Boonstra A, Chajès V, Ueland PM, Slimani N. Dietary intake and biological measurement of folate: a qualitative review of validation studies. Mol Nutr Food Res 2013;57:562-81.   DOI   ScienceOn
26 Dhonukshe-Rutten RA, de Vries JH, de Bree A, van der Put N, van Staveren WA, de Groot LC. Dietary intake and status of folate and vitamin B12 and their association with homocysteine and cardiovascular disease in European populations. Eur J Clin Nutr 2009;63:18-30.   DOI   ScienceOn
27 Park JY, Nicolas G, Freisling H, Biessy C, Scalbert A, Romieu I, Chajès V, Chuang SC, Ericson U, Wallström P, Ros MM, Peeters PH, Mattiello A, Palli D, María Huerta J, Amiano P, Halkjær J, Dahm CC, Trichopoulou A, Orfanos P, Teucher B, Feller S, Skeie G, Engeset D, Boutron-Ruault MC, Clavel-Chapelon F, Crowe F, Khaw KT, Vineis P, Slimani N. Comparison of standardised dietary folate intake across ten countries participating in the European Prospective Investigation into Cancer and Nutrition. Br J Nutr 2012;108:552-69.   DOI   ScienceOn
28 Jiang R, Hu FB, Giovannucci EL, Rimm EB, Stampfer MJ, Spiegelman D, Rosner BA, Willett WC. Joint association of alcohol and folate intake with risk of major chronic disease in women. Am J Epidemiol 2003;158:760-71.   DOI   ScienceOn
29 Mito N, Takimoto H, Umegaki K, Ishiwaki A, Kusama K, Fukuoka H, Ohta S, Abe S, Yamawaki M, Ishida H, Yoshiike N. Folate intakes and folate biomarker profiles of pregnant Japanese women in the first trimester. Eur J Clin Nutr 2007;61:83-90.   DOI   ScienceOn
30 Mannino DM, Mulinare J, Ford ES, Schwartz J. Tobacco smoke exposure and decreased serum and red blood cell folate levels: data from the Third National Health and Nutrition Examination Survey. Nicotine Tob Res 2003;5:357-62.   DOI   ScienceOn
31 Nakazato M, Maeda T, Takamura N, Wada M, Yamasaki H, Johnston KE, Tamura T. Relation of body mass index to blood folate and total homocysteine concentrations in Japanese adults. Eur J Nutr 2011;50:581-5.   DOI   ScienceOn
32 Zappacosta B, Persichilli S, Iacoviello L, Di Castelnuovo A, Graziano M, Gervasoni J, Leoncini E, Cimino G, Mastroiacovo P. Folate, vitamin B12 and homocysteine status in an Italian blood donor population. Nutr Metab Cardiovasc Dis 2013;23:473-80.   DOI   ScienceOn