1 |
Bai X, Ma D, Liu A, Shen X, Wang QJ, Liu Y & Jiang Y (2007). Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38. Science 318:977-980
DOI
PUBMED
ScienceOn
|
2 |
Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B & Jacinto E (2008). The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J 27:1932-1943
DOI
ScienceOn
|
3 |
Fahien LA, MacDonald MJ, Kmiotek EH, Mertz RJ & Fahien CM (1988). Regulation of insulin release by factors that also modify glutamate dehydrogenase. J Biol Chem 263:13610-13614
|
4 |
Findlay GM, Yan L, Procter J, Mieulet V & Lamb RF (2007). A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling. Biochem J 403:13-20
DOI
ScienceOn
|
5 |
Gao M & Kaiser CA (2006). A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast. Nat Cell Biol 8:657-667
DOI
ScienceOn
|
6 |
Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ & Sabatini DM (2006). Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell 11:859-871
DOI
ScienceOn
|
7 |
Hall DJ, Grewal SS, de la Cruz AF & Edgar BA (2007). Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila. BMC Biol 5:10
DOI
PUBMED
|
8 |
Hara K, Yonezawa K, Weng QP, Kozlowski MT, Belham C & Avruch J (1998). Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem 273:14484-14494
DOI
ScienceOn
|
9 |
Ikenoue T, Inoki K, Yang Q, Zhou X & Guan KL (2008). Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J 27:1919-1931
DOI
ScienceOn
|
10 |
Inoki K, Li Y, Xu T & Guan KL (2003a). Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 17:1829-1834
DOI
ScienceOn
|
11 |
Inoki K, Zhu T & Guan KL (2003b). TSC2 mediates cellular energy response to control cell growth and survival. Cell 115:577-590
DOI
ScienceOn
|
12 |
Juhasz G, Hill JH, Yan Y, Sass M, Baehrecke EH, Backer JM & Neufeld TP (2008). The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol 181:655-666
DOI
ScienceOn
|
13 |
Long X, Ortiz-Vega S, Lin Y & Avruch J (2005b). Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency. J Biol Chem 280:23433-23436
DOI
ScienceOn
|
14 |
Kim E, Goraksha-Hicks P, Li L, Neufeld TP & Guan KL (2008). Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol 10:935-945
DOI
ScienceOn
|
15 |
Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D, Oppliger W, Jenoe P & Hall MN (2002). Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10:457-468
DOI
ScienceOn
|
16 |
Long X, Lin Y, Ortiz-Vega S, Yonezawa K & Avruch J (2005a). Rheb binds and regulates the mTOR kinase. Curr Biol 15:702-713
DOI
ScienceOn
|
17 |
Lynch CJ, Fox HL, Vary TC, Jefferson LS & Kimball SR (2000). Regulation of amino acid-sensitive TOR signaling by leucine analogues in adipocytes. J Cell Biochem 77:234-251
DOI
ScienceOn
|
18 |
Nobukuni T, Joaquin M, Roccio M, Dann SG, Kim SY, Gulati P, Byfield MP, Backer JM, Natt F, Bos JL, Zwartkruis FJ & Thomas G (2005). Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci U S A 102:14238-14243
DOI
ScienceOn
|
19 |
Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument- Bromage H, Tempst P & Sabatini DM (2004). Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 14:1296-1302
DOI
ScienceOn
|
20 |
Smith EM, Finn SG, Tee AR, Browne GJ & Proud CG (2005). The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. J Biol Chem 280:18717-18727
DOI
ScienceOn
|
21 |
Wang L, Harris TE, Roth RA & Lawrence JC Jr (2007). PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding. J Biol Chem 282:20036-20044
DOI
ScienceOn
|
22 |
Yan Y, Flinn RJ, Wu H, Schnur RS & Backer JM (2009). hVps15, but not Ca(2+)/CaM, is required for the activity and regulation of hVps34 in mammalian cells. Biochem J 417:747-755
DOI
ScienceOn
|
23 |
Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, Tokunaga C, Avruch J & Yonezawa K (2002). Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110:177-189
DOI
ScienceOn
|
24 |
Hyde R, Taylor PM & Hundal HS (2003). Amino acid transporters: roles in amino acid sensing and signalling in animal cells. Biochem J 373:1-18
DOI
ScienceOn
|
25 |
Miotto G, Venerando R, Khurana KK, Siliprandi N & Mortimore GE (1992). Control of hepatic proteolysis by leucine and isovaleryl-Lcarnitine through a common locus. Evidence for a possible mechanism of recognition at the plasma membrane. J Biol Chem 267:22066-22072
|
26 |
Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA & Sabatini DM (2007). PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell 25:903-915
DOI
ScienceOn
|
27 |
Lee CH, Inoki K & Guan KL (2007). mTOR pathway as a target in tissue hypertrophy. Annu Rev Pharmacol Toxicol 47:443-467
DOI
ScienceOn
|
28 |
Sabatini DM, Erdjument-Bromage H, Lui M, Tempst P & Snyder SH (1994). RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 78:35-43
DOI
ScienceOn
|
29 |
Backer JM (2008). The regulation and function of Class III PI3Ks: novel roles for Vps34. Biochem J 410:1-17
DOI
ScienceOn
|
30 |
Shintani T & Klionsky DJ (2004). Autophagy in health and disease: a double-edged sword. Science 306:990-995
DOI
PUBMED
ScienceOn
|
31 |
Hay N & Sonenberg N (2004). Upstream and downstream of mTOR. Genes Dev 18:1926-1945
DOI
ScienceOn
|
32 |
Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA & Pan D (2003). Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol 5:578-581
DOI
ScienceOn
|
33 |
Garlick PJ & Grant I (1988). Amino acid infusion increases the sensitivity of muscle protein synthesis in vivo to insulin. Effect of branched-chain amino acids. Biochem J 254:579-584
DOI
|
34 |
Lindmo K & Stenmark H (2006). Regulation of membrane traffic by phosphoinositide 3-kinases. J Cell Sci 119:605-614
DOI
ScienceOn
|
35 |
Miotto G, Venerando R, Marin O, Siliprandi N & Mortimore GE (1994). Inhibition of macroautophagy and proteolysis in the isolated rat hepatocyte by a nontransportable derivative of the multiple antigen peptide Leu8-Lys4-Lys2-Lys-beta Ala. J Biol Chem 269:25348-25353
|
36 |
Balage M, Sinaud S, Prod'homme M, Dardevet D, Vary TC, Kimball SR, Jefferson LS & Grizard J (2001). Amino acids and insulin are both required to regulate assembly of the eIF4E. eIF4G complex in rat skeletal muscle. Am J Physiol 281:E565-574
|
37 |
Dubouloz F, Deloche O, Wanke V, Cameroni E & De Virgilio C (2005). The TOR and EGO protein complexes orchestrate microautophagy in yeast. Mol Cell 19:15-26
DOI
ScienceOn
|
38 |
Garcia-Martinez JM & Alessi DR (2008). mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serumand glucocorticoid-induced protein kinase 1 (SGK1). Biocheml J 416:375-385
DOI
ScienceOn
|
39 |
Redpath NT, Foulstone EJ & Proud CG (1996). Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathway. EMBO J 15:2291-2297
|
40 |
Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L & Sabatini DM (2008). The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320:1496-1501
DOI
PUBMED
ScienceOn
|
41 |
Haussinger D (1996). The role of cellular hydration in the regulation of cell function. Biochem J 313:697-710
DOI
|
42 |
Nicklin P, Bergman P, Zhang B, Triantafellow E, Wang H, Nyfeler B, Yang H, Hild M, Kung C, Wilson C, Myer VE, MacKeigan JP, Porter JA, Wang YK, Cantley LC, Finan PM & Murphy LO (2009). Bidirectional transport of amino acids regulates mTOR and autophagy. Cell 136:521-534
DOI
ScienceOn
|
43 |
Cruz MC, Cavallo LM, Gorlach JM, Cox G, Perfect JR, Cardenas ME & Heitman J (1999). Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. Mol Cell Biol 19:4101-4112
DOI
|
44 |
Inoki K, Corradetti MN & Guan KL (2005b). Dysregulation of the TSC-mTOR pathway in human disease. Nat Gene 37:19-24
DOI
ScienceOn
|
45 |
Yang Q & Guan KL (2007). Expanding mTOR signaling. Cell Res 17:666-681
DOI
ScienceOn
|
46 |
Hsu YC, Chern JJ, Cai Y, Liu M & Choi KW (2007). Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase. Nature 445:785-788
DOI
ScienceOn
|
47 |
Blommaart EF, Luiken JJ, Blommaart PJ, van Woerkom GM & Meijer AJ (1995). Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes. J Biol Chem 270:2320-2326
DOI
ScienceOn
|
48 |
Iiboshi Y, Papst PJ, Kawasome H, Hosoi H, Abraham RT, Houghton PJ & Terada N (1999). Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation. J Biol Chem 274:1092-1099
DOI
ScienceOn
|
49 |
McDaniel ML, Marshall CA, Pappan KL & Kwon G (2002). Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells. Diabetes 51:2877-2885
DOI
ScienceOn
|
50 |
Byfield MP, Murray JT & Backer JM (2005). hVps34 is a nutrientregulated lipid kinase required for activation of p70 S6 kinase. J Biol Chem 280:33076-33082
DOI
ScienceOn
|
51 |
Oshiro N, Takahashi R, Yoshino K, Tanimura K, Nakashima A, Eguchi S, Miyamoto T, Hara K, Takehana K, Avruch J, Kikkawa U & Yonezawa K (2007). The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1. J Biol Chem 282:20329-20339
DOI
ScienceOn
|
52 |
Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H, Kozma SC, Hafen E, Bos JL & Thomas G (2003). Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell 11:1457-1466
DOI
ScienceOn
|
53 |
Menand B, Desnos T, Nussaume L, Berger F, Bouchez D, Meyer C & Robaglia C (2002). Expression and disruption of the Arabidopsis TOR (target of rapamycin) gene. Proc Natl Acad Sci U S A 99:6422-6427
DOI
ScienceOn
|
54 |
Nobukuni T, Kozma SC & Thomas G (2007). hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling. Curr Opin Cell Biol 19:135-141
DOI
ScienceOn
|
55 |
Roccio M, Bos JL & Zwartkruis FJ (2006). Regulation of the small GTPase Rheb by amino acids. Oncogene 25:657-664
DOI
ScienceOn
|
56 |
Tee AR, Manning BD, Roux PP, Cantley LC & Blenis J (2003). Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 13:1259-1268
DOI
ScienceOn
|
57 |
Heitman J, Movva NR & Hall MN (1991). Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253:905-909
DOI
PUBMED
|
58 |
Dennis PB, Jaeschke A, Saitoh M, Fowler B, Kozma SC & Thomas G (2001). Mammalian TOR: a homeostatic ATP sensor. Science 294:1102-1105
DOI
PUBMED
ScienceOn
|
59 |
Guertin DA & Sabatini DM (2007). Defining the role of mTOR in cancer. Cancer cell 12:9-22
DOI
ScienceOn
|
60 |
Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ & Kim DH (2007). Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol 9:316-323
DOI
ScienceOn
|
61 |
Odorizzi G, Babst M & Emr SD (2000). Phosphoinositide signaling and the regulation of membrane trafficking in yeast. Trends Biochem Sci 25:229-235
DOI
PUBMED
ScienceOn
|
62 |
Saucedo LJ, Gao X, Chiarelli DA, Li L, Pan D & Edgar BA (2003). Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat Cell Biol 5:566-571
DOI
ScienceOn
|
63 |
Pearce LR, Huang X, Boudeau J, Pawlowski R, Wullschleger S, Deak M, Ibrahim AF, Gourlay R, Magnuson MA & Alessi DR (2007). Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J 405:513-522
DOI
ScienceOn
|
64 |
Inoki K, Ouyang H, Li Y & Guan KL (2005a). Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev 69:79-100
DOI
ScienceOn
|
65 |
Brown EJ, Albers MW, Shin TB, Ichikawa K, Keith CT, Lane WS & Schreiber SL (1994). A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 369:756-758
DOI
PUBMED
ScienceOn
|
66 |
Chiu MI, Katz H & Berlin V (1994). RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex. Proc Natl Acad Sci U S A 91:12574-12578
DOI
ScienceOn
|
67 |
Kim DH, Sarbassov DD, Ali SM, Latek RR, Guntur KV, Erdjument-Bromage H, Tempst P & Sabatini DM (2003). GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 11:895-904
DOI
ScienceOn
|
68 |
Long W, Saffer L, Wei L & Barrett EJ (2000). Amino acids regulate skeletal muscle PHAS-I and p70 S6-kinase phosphorylation independently of insulin. Am J Physiol 279:E301-306
|
69 |
Sener A & Malaisse WJ (1980). L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase. Nature 288:187-189
DOI
ScienceOn
|
70 |
Abraham RT & Wiederrecht GJ (1996). Immunopharmacology of rapamycin. Annu Rev Immunol 14:483-510
DOI
ScienceOn
|
71 |
Fingar DC, Salama S, Tsou C, Harlow E & Blenis J (2002). Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev 16:1472-1487
DOI
ScienceOn
|
72 |
May ME & Buse MG (1989). Effects of branched-chain amino acids on protein turnover. Diabetes Metabol Rev 5:227-245
DOI
ScienceOn
|
73 |
Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument- Bromage H, Tempst P & Sabatini DM (2002). mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110:163-175
DOI
ScienceOn
|
74 |
Jacinto E, Loewith R, Schmidt A, Lin S, Ruegg MA, Hall A & Hall MN (2004). Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 6:1122-1128
DOI
ScienceOn
|
75 |
Oldham S, Montagne J, Radimerski T, Thomas G & Hafen E (2000). Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev 14:2689-2694
DOI
ScienceOn
|
76 |
Yan Y & Backer JM (2007). Regulation of class III (Vps34) PI3Ks. Biochem Soc Trans 35:239-241
DOI
ScienceOn
|
77 |
Gulati P, Gaspers LD, Dann SG, Joaquin M, Nobukuni T, Natt F, Kozma SC, Thomas AP & Thomas G (2008). Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. Cell Metab 7:456-465
DOI
ScienceOn
|
78 |
Kim E & Guan KL (2009). RAG GTPases in nutrient-mediated TOR signaling pathway. Cell Cycle 8:[in publication]
|
79 |
Schmelzle T & Hall MN (2000). TOR, a central controller of cell growth. Cell 103:253-262
DOI
ScienceOn
|
80 |
Xu G, Kwon G, Cruz WS, Marshall CA & McDaniel ML (2001). Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells. Diabetes 50:353-360
DOI
ScienceOn
|
81 |
Shah OJ, Anthony JC, Kimball SR & Jefferson LS (2000). 4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle. Am J Physiol 279:E715-729
|