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http://dx.doi.org/10.4014/jmb.1709.09042

Lactobacillus plantarum C29 Alleviates TNBS-Induced Memory Impairment in Mice  

Lee, Hae-Ji (Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University)
Jeong, Jin-Ju (Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University)
Han, Myung Joo (Department of Food and Nutrition, Kyung Hee University)
Kim, Dong-Hyun (Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University)
Publication Information
Journal of Microbiology and Biotechnology / v.28, no.1, 2018 , pp. 175-179 More about this Journal
Abstract
In a preliminary study, Lactobacillus plantarum C29 was found to suppress 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice. Therefore, to understand whether an anti-colitic probiotic C29 could attenuate memory impairment, we examined the effects of C29 on TNBS-induced memory impairment in mice. Orally administered Lactobacillus plantarum C29 attenuated TNBS-induced memory impairment in mice in the Y-maze, noble object, and passive avoidance task tests. C29 treatment increased TNBS-suppressed hippocampal brain-derived neurotrophic factor expression and inhibited TNBS-induced hippocampal NF-${\kappa}B$ activation and blood LPS levels. Moreover, C29 restored the TNBS-disturbed gut microbiota composition. These findings suggest that C29 can alleviate memory impairment presumably by restoring the gut microbiota composition.
Keywords
Lactobacillus plantarum; memory impairment; colitis; gut microbiota;
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