Browse > Article
http://dx.doi.org/10.4014/jmb.1709.09001

Kaposi's Sarcoma-Associated Herpesvirus Infection Modulates the Proliferation of Glioma Stem-Like Cells  

Jeon, Hyungtaek (Department of Microbiology and Immunology, Eulji University School of Medicine)
Kang, Yun Hee (Eulji Biomedical Science Research Institute, Eulji University School of Medicine)
Yoo, Seung-Min (Department of Microbiology and Immunology, Eulji University School of Medicine)
Park, Myung-Jin (Divisions of Radiation Cancer Research, Research Center for Radio-Senescence, Korea Institute of Radiological and Medical Sciences)
Park, Jong Bae (Department of System Cancer Science, Graduate School of Cancer Science and Policy, National Cancer Center)
Lee, Seung-Hoon (Department of Neurosurgery, Eulji University School of Medicine)
Lee, Myung-Shin (Department of Microbiology and Immunology, Eulji University School of Medicine)
Publication Information
Journal of Microbiology and Biotechnology / v.28, no.1, 2018 , pp. 165-174 More about this Journal
Abstract
Glioblastoma multiforme is the most lethal malignant brain tumor. Despite many intensive studies, the prognosis of glioblastoma multiforme is currently very poor, with a median overall survival duration of 14 months and 2-year survival rates of less than 10%. Although viral infections have been emphasized as potential cofactors, their influences on pathways that support glioblastoma progression are not known. Some previous studies indicated that human Kaposi's sarcoma-associated herpesvirus (KSHV) was detected in healthy brains, and its microRNA was also detected in glioblastoma patients' plasma. However, a direct link between KSHV infection and glioblastoma is currently not known. In this study, we infected glioblastoma cells and glioma stem-like cells (GSCs) with KSHV to establish an in vitro cell model for KSHV-infected glioblastoma cells and glioma stem-like cells in order to identify virologic outcomes that overlap with markers of aggressive disease. Latently KSHV-infected glioblastoma cells and GSCs were successfully established. Additionally, using these cell models, we found that KSHV infection modulates the proliferation of glioma stem-like cells.
Keywords
KSHV; HHV-8; glioblastoma; glioma stem-like cell; proliferation;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Mao P, Joshi K, Li J, Kim SH, Li P, Santana-Santos L, et al. 2013. Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3. Proc. Natl. Acad. Sci. USA 110: 8644-8649.   DOI
2 Prasad A, Lu M, Lukac DM, Zeichner SL. 2012. An alternative Kaposi's sarcoma-associated herpesvirus replication program triggered by host cell apoptosis. J. Virol. 86: 4404-4419.
3 Li W, Jia X, Shen C, Zhang M, Xu J, Shang Y, et al. 2016. A KSHV microRNA enhances viral latency and induces angiogenesis by targeting GRK2 to activate the CXCR2/AKT pathway. Oncotarget 7: 32286-32305.
4 Wen PY, Kesari S. 2008. Malignant gliomas in adults. N Engl. J. Med. 359: 492-507.   DOI
5 Nieder C, Grosu AL, Astner S, Molls M. 2005. Treatment of unresectable glioblastoma multiforme. Anticancer Res. 25:4605-4610.
6 Huse JT, Holland EC. 2010. Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma. Nat. Rev. Cancer 10: 319-331.   DOI
7 Filatova A, Acker T, Garvalov BK. 2013. The cancer stem cell niche(s): the crosstalk between glioma stem cells and their microenvironment. Biochim. Biophys. Acta 1830: 2496-2508.   DOI
8 Neman J, Jandial R. 2010. Decreasing glioma recurrence through adjuvant cancer stem cell inhibition. Biologics 4:157-162.
9 Zhou ZH, Ping YF, Yu SC, Yi L, Yao XH, Chen JH, et al. 2009. A novel approach to the identification and enrichment of cancer stem cells from a cultured human glioma cell line. Cancer Lett. 281: 92-99.
10 Evers P, Lee PP, DeMarco J, Agazaryan N, Sayre JW, Selch M, et al. 2010. Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma. BMC Cancer 10: 384.   DOI
11 Vidone M, Alessandrini F, Marucci G, Farnedi A, de Biase D, Ricceri F, et al. 2014. Evidence of association of human papillomavirus with prognosis worsening in glioblastoma multiforme. Neuro Oncol. 16: 298-302.
12 Ranganathan P, Clark PA, Kuo JS, Salamat MS, Kalejta RF. 2012. Significant association of multiple human cytomegalovirus genomic loci with glioblastoma multiforme samples. J. Virol. 86: 854-864.   DOI
13 Merelli E, Bedin R, Sola P, Barozzi P, Mancardi GL, Ficarra G, et al. 1997. Human herpes virus 6 and human herpes virus 8 DNA sequences in brains of multiple sclerosis patients, normal adults and children. J. Neurol. 244: 450-454.   DOI
14 Hawkins C, Croul S. 2011. Viruses and human brain tumors: cytomegalovirus enters the fray. J. Clin. Invest. 121: 3831-3833.   DOI
15 Ganem D . 2010. KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine. J. Clin. Invest. 120: 939-949.   DOI
16 Chan PK, Ng HK, Cheung JL, Cheng AF. 2000. Survey for the presence and distribution of human herpesvirus 8 in healthy brain. J. Clin. Microbiol. 38: 2772-2773.
17 Herman A, Gruden K, Blejec A, Podpecan V, Motaln H, Rozman P, et al. 2015. Analysis of glioblastoma patients' plasma revealed the presence of microRNAs with a prognostic impact on survival and those of viral origin. PLoS One 10: e0125791.   DOI
18 Opsahl ML, Kennedy PG. 2006. Investigating the presence of human herpesvirus 7 and 8 in multiple sclerosis and normal control brain tissue. J. Neurol. Sci. 240: 37-44.
19 Jha HC, Mehta D, Lu J, El-Naccache D, Shukla SK, Kovacsics C, et al. 2015. Gammaherpesvirus infection of human neuronal cells. MBio 6: e01844-e01815.
20 Cho HJ, Song MJ. 2014. A gammaherpesvirus establishes persistent infection in neuroblastoma cells. Mol. Cells 37: 518-525.   DOI
21 Lee MS, Yuan H, Jeon H, Zhu Y, Yoo S, Shi S, et al. 2016. Human mesenchymal stem cells of diverse origins support persistent infection with Kaposi's sarcoma-associated herpesvirus and manifest distinct angiogenic, invasive, and transforming phenotypes. MBio 7: e02109-e02115.
22 Yoo S, Jang J, Kim S, Cho H, Lee MS. 2012. Expression of DcR3 and its effects in Kaposi's sarcoma-associated herpesvirusinfected human endothelial cells. Intervirology 55: 45-52.   DOI
23 Yoo SM, Ahn AK, Seo T, Hong HB, Chung MA, Jung SD, et al. 2008. Centrifugal enhancement of Kaposi's sarcomaassociated virus infection of human endothelial cells in vitro. J. Virol. Methods 154: 160-166.   DOI
24 Lee J, Jeon H, Yoo SM, Park J, Lee MS. 2016. The role of Kaposi's sarcoma-associated herpesvirus infection in the proliferation of human bladder cancer cells. Tumour Biol. 37: 2587-2596.   DOI
25 Lee MS, Jones T, Song DY, Jang JH, Jung JU, Gao SJ. 2014. Exploitation of the complement system by oncogenic Kaposi's sarcoma-associated herpesvirus for cell survival and persistent infection. PLoS Pathog. 10: e1004412.   DOI
26 Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, et al. 2010. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17: 98-110.   DOI
27 Phillips HS, Kharbanda S, Chen R, Forrest WF, Soriano RH, Wu TD, et al. 2006. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 9: 157-173.   DOI
28 Scheurer ME, Bondy ML, Aldape KD, Albrecht T, El-Zein R. 2008. Detection of human cytomegalovirus in different histological types of gliomas. Acta Neuropathol. 116: 79-86.   DOI
29 Chi J, Gu B, Zhang C, Peng G, Zhou F, Chen Y, et al. 2012. Human herpesvirus 6 latent infection in patients with glioma. J. Infect. Dis. 206: 1394-1398.   DOI
30 Yin J, Park G, Kim TH, Hong JH, Kim YJ, Jin X, et al. 2015. Pigment epithelium-derived factor (PEDF) expression induced by EGFRvIII promotes self-renewal and tumor progression of glioma stem cells. PLoS Biol. 13: e1002152.