Browse > Article
http://dx.doi.org/10.3746/pnf.2015.20.2.88

Hypoglycemic Effect of Jicama (Pachyrhizus erosus) Extract on Streptozotocin-Induced Diabetic Mice  

Park, Chan Joo (Department of Food Science and Nutrition, Pusan National University)
Han, Ji-Sook (Department of Food Science and Nutrition, Pusan National University)
Publication Information
Preventive Nutrition and Food Science / v.20, no.2, 2015 , pp. 88-93 More about this Journal
Abstract
The purpose of this research was to investigate the inhibitory effect of jicama extract on ${\alpha}$-glucosidase activity, ${\alpha}$-amylase activity, and postprandial hyperglycemia in streptozotocin (STZ)-induced diabetic mice. Jicama extract showed prominent inhibitory effects against ${\alpha}$-glucosidase and ${\alpha}$-amylase. The $IC_{50}$ values of jicama extract against ${\alpha}$-glucosidase and ${\alpha}$-amylase were $0.083{\pm}0.004$ and $0.091{\pm}0.017mg/mL$, respectively. The increase in postprandial blood glucose levels was more significantly suppressed in the jicama extract-administered group than in the control group of both STZ-induced diabetic and normal mice. Blood glucose levels of the control group increased to $383.75{\pm}11.54$ and $402.50{\pm}15.32mg/dL$ at 30 and 60 min after a meal and decreased to $349.67{\pm}11.62mg/dL$ at 120 min. However, postprandial blood glucose levels were significantly decreased, when diabetic mice were fed with jicama extract ($342.00{\pm}15.73$, $367.00{\pm}13.00$, and $329.67{\pm}12.43mg/dL$ at 30, 60, and 120 min, respectively). Furthermore, the area under the curve was significantly decreased with jicama extract administration in diabetic mice (P<0.05). Therefore, these results indicate that jicama extract may help decrease postprandial blood glucose level by inhibiting ${\alpha}$-glucosidase.
Keywords
jicama extract; postprandial hyperglycemia; diabetic mice;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Baron AD. 1998. Postprandial hyperglycemia and ${\alpha}$-glucosidase inhibitors. Diabetes Res Clin Pract 40: S51-S55.   DOI   ScienceOn
2 Ceriello A, Taboga C, Tonutti L, Quagliaro L, Piconi L, Bais B, Da Ros R, Motz E. 2002. Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation: effects of short- and long-term simvastatin treatment. Circulation 106: 1211-1218.   DOI   ScienceOn
3 Ceriello A. 2005. Postprandial hyperglycemia and diabetes complications: is it time to treat? Diabetes 54: 1-7.   DOI   ScienceOn
4 Shamhart PE, Luther DJ, Adapala RK, Bryant JE, Petersen KA, Meszaros JG, Thodeti CK. 2014. Hyperglycemia enhances function and differentiation of adult rat cardiac fibroblasts. Can J Physiol Pharmacol 92: 598-604.   DOI   ScienceOn
5 Huang W, Huang J, Liu Q, Lin F, He Z, Zeng Z, He L. 2015. Neutrophil-lymphocyte ratio is a reliable predictive marker for early-stage diabetic nephropathy. Clin Endocrinol (Oxf) 82: 229-233.   DOI   ScienceOn
6 Bril V. 2014. Neuromuscular complications of diabetes mellitus. Continuum (Minneap Minn) 20: 531-544.
7 Stitt AW, Lois N, Medina RJ, Adamson P, Curtis TM. 2013. Advances in our understanding of diabetic retinopathy. Clin Sci (Lond) 125: 1-17.   DOI
8 Tan MC, Wong TW, Ng OC, Joseph A, Hejar AR. 2014. Metabolic syndrome components and prevalence of cardiovascular disease among type 2 diabetic patients in Malaysia. Southeast Asian J Trop Med Public Health 45: 226-235.
9 He K, Shi JC, Mao XM. 2014. Safety and efficacy of acarbose in the treatment of diabetes in Chinese patients. Ther Clin Risk Manag 10: 505-511.
10 Prashanth D, Padmaja R, Samiulla DS. 2001. Effect of certain plant extracts on ${\alpha}$-amylase activity. Fitoterapia 72: 179-181.   DOI   ScienceOn
11 Kalra S. 2014. Alpha glucosidase inhibitors. J Pak Med Assoc 64: 474-476.
12 Moorthy NS, Ramos MJ, Fernandes PA. 2012. Studies on ${\alpha}$-glucosidase inhibitors development: magic molecules for the treatment of carbohydrate mediated diseases. Mini Rev Med Chem 12: 713-720.   DOI
13 Nieto C. 1991. Agronomical and bromatological studies in jicama (Polymnia sonchifolia Poep et Endl.). Arch Latinoam Nutr 41: 213-221.
14 Meyer D, Bayarri S, Tarrega A, Costell E. 2011. Inulin as texture modifier in dairy products. Food Hydrocolloids 25: 1881-1890.   DOI   ScienceOn
15 Yun JW. 1996. Fructooligosaccharides-occurrence, preparation, and application. Enzyme Microb Technol 19: 107-117.   DOI   ScienceOn
16 Oku T, Tokunaga T, Hosoya N. 1984. Nondigestiblility of a new sweetener, "Neosugar", in the rat. J Nutr 114: 1574- 1578.   DOI
17 Apolinario AC, de Lima Damasceno BP, de Macedo Beltrao NE, Pessoa A, Converti A, da Silva JA. 2014. Inulin-type fructans: A review on different aspects of biochemical and pharmaceutical technology. Carbohydr Polym 101: 368-378.   DOI   ScienceOn
18 Cherbut C. 2002. Inulin and oligofructose in the dietary fibre concept. Br J Nutr 87: S159-S162.   DOI
19 Edwards CA, Johnson IT, Read NW. 1988. Do viscous polysaccharides slow absorption by inhibiting diffusion or convection? Eur J Clin Nutr 42: 307-312.
20 Lebovitz HE. 1998. Postprandial hyperglycaemic state: importance and consequences. Diabetes Res Clin Pract 40: S27- S28.   DOI   ScienceOn
21 Salimifar M, Fatehi-Hassanabad Z, Fatehi M. 2013. A review on natural products for controlling type 2 diabetes with an emphasis on their mechanisms of actions. Curr Diabetes Rev 9: 402-411.   DOI
22 Kastorini CM, Panagiotakos DB. 2009. Dietary patterns and prevention of type 2 diabetes: from research to clinical practice; a systematic review. Curr Diabetes Rev 5: 221-227.   DOI   ScienceOn
23 Zimmet P, Alberti KGMM, Shaw J. 2001. Global and societal implications of the diabetes epidemic. Nature 414: 782-787.   DOI   ScienceOn
24 Joshi SR, Ramachandran A, Chadha M, Chatterjee S, Rathod R, Kalra S. 2014. Acarbose plus metformin fixed-dose combination in the management of type 2 diabetes. Expert Opin Pharmacother 15: 1611-1620.   DOI   ScienceOn
25 van de Laar FA, Lucassen PL, Akkermans RP, van de Lisdonk EH, Rutten GE, van Weel C. 2005. ${\alpha}$-Glucosidase inhibitors for patients with type 2 diabetes: results from a Cochrane systematic review and meta-analysis. Diabetes Care 28: 154-163.   DOI   ScienceOn
26 Watanabe J, Kawabata J, Kurihara H, Niki R. 1997. Isolation and identification of ${\alpha}$-glucosidase inhibitors from tochucha (Eucommia ulmoides). Biosci Biotechnol Biochem 61: 177-180.   DOI   ScienceOn
27 Kim SK, Choi HJ, Won JF, Park JH, Lee IJ, Park SY. 2009. Introduction of yam bean (Pachyrhizus spp.) in Korea. Korean J Plant Res 22: 546-551.
28 Fernandez MV, Warid WA, Loaiza JM, Montiel A. 1997. Developmental patterns of jicama (Pachyrhizus erosus (L.) Urban) plant and the chemical constituents of roots grown in Sonora, Mexico. Plant Foods Hum Nutr 50: 279-286.   DOI
29 Mussury RM, Scalon SP, Silva MA, Silva TF, Gomes H, Gassi R. 2013. Postharvest conservation of the tuberous roots of Pachyrhizus ahipa (Wedd) Parodi. An Acad Bras Cienc 85: 761-768.   DOI   ScienceOn
30 Kumalasari ID, Nishi K, Harmayani E, Raharjo S, Sugahara T. 2014. Immunomodulatory activity of Bengkoang (Pachyrhizus erosus) fiber extract in vitro and in vivo. Cytotechnology 66: 75-85.   DOI   ScienceOn
31 Bonsu NK, Johnson CS, McLeod KM. 2011. Can dietary fructans lower serum glucose? J Diabetes 3: 58-66.   DOI   ScienceOn
32 Blackburn NA, Redfern JS, Jarjis H, Holgate AM, Hanning I, Scarpello JH, Johnson IT, Read NW. 1984. The mechanism of action of guar gum in improving glucose tolerance in man. Clin Sci (Lond) 66: 329-336.   DOI
33 Pastors JG, Blaisdell PW, Balm TK, Asplin CM, Pohl SL. 1991. Psyllium fiber reduces rise in postprandial glucose and insulin concentrations in patients with non-insulin-dependent diabetes. Am J Clin Nutr 53: 1431-1435.   DOI
34 Ou S, Kwok K, Li Y, Fu L. 2001. In vitro study of possible role of dietary fiber in lowering postprandial serum glucose. J Agric Food Chem 49: 1026-1029.   DOI   ScienceOn
35 Dennis JW, Laferté S, Waghorne C, Breitman ML, Kerbel RS. 1987. Beta 1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis. Science 236: 582-585.   DOI
36 Gruters RA, Neefjes JJ, Tersmette M, de Goede RE, Tulp A, Huisman HG, Miedema F, Ploegh HL. 1987. Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. Nature 330: 74-77.   DOI   ScienceOn
37 Yale JF. 2005. Oral antihyperglycemic agents and renal disease: new agents, new concepts. J Am Soc Nephrol 16: S7-S10.   DOI   ScienceOn