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http://dx.doi.org/10.3746/pnf.2014.19.4.363

Zinc Restored the Decreased Vascular Smooth Muscle Cell Viability under Atherosclerotic Calcification Conditions  

Shin, Mee-Young (Department of Food Science and Nutrition, College of Human Ecology, Andong National University)
Kwun, In-Sook (Department of Food Science and Nutrition, College of Human Ecology, Andong National University)
Publication Information
Preventive Nutrition and Food Science / v.19, no.4, 2014 , pp. 363-366 More about this Journal
Abstract
Zinc is considered to be involved in maintaining healthy vascular condition. Atherosclerotic calcification of vascular smooth muscle cells (VSMCs) occurs via the mechanism of cell death; therefore, cell viability is a critical factor for preventing VSMC calcification. In this study, we tested whether zinc affected VSMC viability under both normal physiological non-calcifying (0 mM P) and atherosclerotic calcifying conditions (3 and 5 mM P), since VSMC physiological characters change during the VSMC calcification process. The study results showed that an optimal zinc level ($15{\mu}M$) restored the decreased VSMC viability which was induced under low zinc levels (0 and $1{\mu}M$) and calcifying conditions (3 and 5 mM P) at 9 and 15 days culture. This zinc-protecting effect for VSMC viability is more prominent under atherosclerotic calcifying condition (3 and 5 mM P) than normal condition (0 mM P). Also, the increased VSMC viability was consistent with the decreased Ca and P accumulation in VSMC cell layers. The results suggested that zinc could be an effective biomineral for preventing VSMC calcification under atherosclerotic calcifying conditions.
Keywords
zinc; atherosclerosis; vascular smooth muscle cells (VSMCs); cell viability; VSMC calcification;
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