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http://dx.doi.org/10.3746/pnf.2013.18.1.001

Influence of Squid Liver Powder on Accumulation of Cadmium in Serum, Kidney and Liver of Mice  

Kim, Byoung-Mok (Division of Metabolism and Functionality Research, Korea Food Research Institute)
Lee, Soo-Young (Department of Marine Food Science and Technolgy, Gangneung-Wonju National University)
Jeong, In-Hak (Department of Marine Food Science and Technolgy, Gangneung-Wonju National University)
Publication Information
Preventive Nutrition and Food Science / v.18, no.1, 2013 , pp. 1-10 More about this Journal
Abstract
In this study, the effect of squid liver powder intake on accumulation of cadmium in mice was investigated. Subjects were divided into 4 groups including the control group (CON), squid liver powder group with lipids not removed (SLP100), and squid liver powder groups with lipids removed (LFSLP50 and LFSLP100). Feed intake and food efficiency ratio of squid liver powder groups was significantly higher than the CON. As a result of investigating cadmium content in hair, serum, liver, and kidney during intake of squid liver powder, all groups showed increase in cadmium accumulation through consistent, long-term intake. Especially, cadmium content in liver and kidney of LFSLP100 was significantly higher than the content of SLP100 and CON. As a result of pathological observation on liver and kidney tissues according to squid liver powder diet, LFSLP100 showed most serious pathological symptoms. In case of kidney tissues, degeneration was significantly more severe in LFSLP100 compared to other groups. Such results suggest that cadmium concentration in human body can be increased by ingestion of whole squid including internal organs and that tissues can be damaged by increased cadmium concentration. More specific and systematic studies are deemed necessary.
Keywords
Todarodes pacificus; squid liver; cadmium accumulation; heavy metal; rats;
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1 Dunnick JK. 1995. NTP technical report on toxicity studies of cadmium oxide (CAS No. 1306-19-0) adiministered by inhalation to F344/N rats and B6C3Fb1s mice. NIH Publication 95: 1-106.
2 Lee IS. 2007. Protective effects of Kamdootang on accumulation of cadmium in rats. MS Thesis. Chungnam National University, Daejeon, Korea. p 15-31.
3 Nechay BR, Saunders JP. 1977. Inhibition of renal adenosine triphosphatase by cadmium. J Pharmacol Exp 200: 623-629.
4 Klassen CD, Liu J, Choudhuri S. 1999. Metallothionein: An intracellular protein to protect against cadmium toxicity. Annu Rev Pharmacol Toxicol 39: 267-294.   DOI   ScienceOn
5 Oteiza PI, Adonaylo VN, Keen CL. 1999. Cadmium-induced testes oxidative damage in rats can be influenced by dietary zinc intake. Toxicol 137: 13-22.   DOI   ScienceOn
6 Rhee SJ, Huang PC. 1989. Metallothionein accumulation in CHO cdr cells in response to lead treatment. Chem Biol Interact 72: 347-361.   DOI   ScienceOn
7 Friedman PA, Gesek FA. 1994. Cadmium uptake by kidney distal convoluted tubule cells. Toxicol Appl Pharmacol 128:257-263.   DOI   ScienceOn
8 Coleman JE, Vallee BL. 1961. Metallo carboxy peptidases stability constants and enzymetic characteristics. J Biol Chem 236: 2244-2249.
9 Parizek J. 1957. The destructive effect of cadmium ion on testicular tissue and its prevention by zinc. J Endocrinol 15:56-63.   DOI   ScienceOn
10 Jeoung IG, Ha KS, Choi JD. 2004. Heavy metals in fish and shellfish at the coastal area of Tongyeoung, Korea. J Ins Marine Industry 17: 39-46.
11 Cho YG, Kim GB. 2007. Bioaccumulation of Pb and Cd in blue mussel (Mytilus edulis) and oliver flounder (Paralichthys olivaceus) exposed to rearing media. J Korean Soc Marine Environ Eng 10: 21-28.   과학기술학회마을
12 Bolton JL, Stehr CM, Boyd DT, Burrows DG, Tkalin AV, Lishavskaya TS. 2004. Organic and trace metal contaminants in sediments and English sole tissue from Vancouver Harbour, Canada. Mar Environ Res 57: 19-36.   DOI   ScienceOn
13 Mai K, Li H, Ai Q, Duan Q, Xu W, Zhang C, Zhang L, Tan B, Liufu Z. 2006. Effects of dietary squid viscera meal on growth and cadmium accumulation in tissues of Japanese seabass, Lateolabrax japonicus (Cuvier1828). Aquac Res 37: 1063-1069.   DOI   ScienceOn
14 Park YB. 2010. Characteristics of angiotensin converting enzyme inhibitory peptides from salt-fermented squid liver sauce. J Korean Soc Food Sci Nutr 39: 1654-1659.   과학기술학회마을   DOI   ScienceOn
15 Cherian MG, Goyer RA. 1978. Metallothioneins and their role in the metabolism and toxicity of metals. Life Sci 23: 1-9.
16 Kudo N, Yamashina S, Waku K. 1986. Protection against cadmium toxicity by zinc: Decrease in the Cd-high molecular weight protein fraction in rat liver and kidney on Zn pretreatment. Toxicol 40: 267-277.   DOI   ScienceOn
17 Ellis KJ, Cohn SH, Smith TJ. 1985. Cadmium inhalation exposure estimates: Their significance with respect to kidney and liver cadmium burden. J Toxicol Environ Health 15:173-187.   DOI   ScienceOn
18 Roh JH, Han CK, Seong KS, Lee NH. 2005. Effects of pork on cadmium detoxification in rats. Korean J Food Sci Ani Resour 25: 373-382.   과학기술학회마을
19 Morita S. 1984. Defense mechanisms against cadmium toxicity: I. A biochemical and histological study of the effects of pretreatment with cadmium on the acute oral toxicity of cadmiumin mice. Jpn J Pharmacol 35: 129-141.   DOI
20 Jarup L. 2003. Hazards of heavy metal contamination. Br Med Bull 68: 167-182.   DOI   ScienceOn
21 Wang G, Su MY, Chen YH, Lin FF, Luo D, Gao SF. 2006. Transfer characteristics of cadmium and lead from soil to the edible parts of six vegetable species in southeastern China. Environ Pollut 144: 127-135.   DOI   ScienceOn
22 Arnot JA, Mackay D, Bonnell M. 2008. Estimating metabolic biotransformation rates in fish from laboratory data. Environ Toxicol Chem 27: 341-351.   DOI   ScienceOn
23 Jun JY, Xu XM, Jeong IH. 2007. Heavy metal contents of fish collected from the Korean coast of the east sea. J Korean Fish Soc 40: 362-366.   과학기술학회마을   DOI   ScienceOn
24 Sung DW, Lee YW. 1993. A study on the content of heavy metals of marine fish in Korean coastal water. Korean J Food Hyg 8: 231-240.   과학기술학회마을
25 IARC. 1993. Beryllium, Cadmium, Mercury and Exposures in the Glass Manufacturing Industry. International Agency for Research on Cancer (IARC) Monographs on the Evaluation of Carcinogenic Risks to Humans. Lyon, France. Vol 58, p 41.
26 Nogawa K, Suwazono Y. 2011. Itai-Itai disease. In Encyclopedia of Environmental Health. Elsevier, Burlington, VT, USA. p 308-314.
27 Chan HM, Cherian MG. 1992. Protective roles of metallothionein and glutathione in hepatotoxicity of cadmium. Toxicol 72: 281-290.   DOI   ScienceOn
28 Kagi JHR. 1993. Biological roles and medical implications. In Metallothionein III. Suzuki KY, Imura N, Kimura M, eds. Birkhauser, Basel, Germany. p 29-55.
29 Kagi JH, Kojima Y. 1987. Chemistry and biochemistry of metallothionein. Experientia Suppl 52: 25-62.   DOI
30 Brozoska MM, Moniuszko-Jakoniuk J. 2001. Interactions between cadmium and zink in the organism. Food Chem Toxicol 39: 967-980.   DOI   ScienceOn
31 Piscator M. 1962. Proteinuria in chronic cadmium poisoning. Arch Environ Health 12: 345-359.
32 Goyer RA, Tsuchiya R, Leonard DL, Kahy OH. 1972. Aminoaciduria in Japanese workers in the lead and cadmium industries. Am J Clin Pathol 57: 635-642.   DOI
33 Ramirez DC, Gimenez MS. 2002. Lipid modification in mouse peritoneal macrophages after chronic cadmium exposure. Toxicol 172: 1-12.   DOI   ScienceOn
34 Anderson HR, Anderson O. 1988. Effect of cadmium on hepatic lipid peroxidation in mice. Pharmacol Toxicol 63:173-177.   DOI   ScienceOn
35 Basavaraju SR, Jones TD. 1998. Atherosclerotic risks from chemicals: part I. Toxicological observations and mechanisms of atherosclerosis. Arch Environ Contam Toxicol 35: 152-164.   DOI   ScienceOn
36 Liu J, Liu Y, Sultans SH, Klassen CD. 1999. Metallothionein- null mice are highly susceptible to the hematotoxic and immunotoxic effects of chronic $CdCl_2$ exposure. Toxicol Appl Pharmacol 159: 98-108.   DOI   ScienceOn
37 Buchet JP, Lauwerys R, Roles H, Bernard A, Bruaux P, Claeys F, Ducoffre G, DePlaen P, Staessen J, Amery A, Lijnen P, Thijs L, Rondia D, Sartor F, Saint Remy A, Nick L. 1990. Renal effects of cadmium body burden of the general population. Lancet 336: 699-702.   DOI   ScienceOn
38 Jarup L, Hellstrom L, Alfven T, Carlsson MD, Grubb A, Persson B, Pettersson C, Spang G, Schutz A, Elinder CG. 2000. Low level exposure to cadmium and early kidney damage: the OSCAR study. Occup Environ Med 57: 668-672.   DOI   ScienceOn
39 Jarup L, Berglund M, Elinder CG, Nordberg G, Vahter M. 1998. Health effects of cadmium exposure a review of the literature and a risk estimate. Scand J Work Environ Health 24:1-51.   DOI   ScienceOn
40 WHO. 1992. Environmental Health Criteria 134: Cadmium. Geneva International Program on Chemical Safety.
41 Ando M, Matsui S, Jinno H, Takeda M. 1989. Urinary excretion of cyclic AMP in cadmium intoxicated rats. J Toxicol Environ Health 27: 307-315.   DOI   ScienceOn
42 Tanaka T, Hayashi Y, Ishizawa M. 1983. Subcellular distribution and binding of heavy metals in the untreated liver of the squid: comparison with data from the livers of cadmium and silver-exposed rats. Experientia 39: 746-748.   DOI   ScienceOn
43 Li H, Mai K, Qinghui A, Chunxiao Z, Lu Z. 2009. Effects of dietary squid viscera meal on growth and cadmium accumulation in tissues of large yellow croaker, Pseudosciaena crocea R. Front Agric China 3: 78-83.   DOI
44 Kim SU, Hwang YO, Park AS, Park YA, Ham HJ, Choi SM, Kim JH. 2011. Contents of heavy metals (Hg, Pb, Cd, Cu) and risk assessment in commercial cephalopods. J Korean Soc Food Sci Nutr 40: 606-612.   과학기술학회마을   DOI   ScienceOn
45 AOAC. 2000. Official methods of analysis. International 17th ed. Association of Official Analytical Chemist, Horowitz, ML, USA. p 12-20.
46 Choi SI, Lee JH, Lee SR. 1994. Effect of green tea beverage for the removal of cadmium and lead by animal experiments. Korean J Food Sci Technol 26: 745-749.   과학기술학회마을
47 Bremner I. 1987. Cadmium toxicity: Nutritional influence and the role of metallothionein. World Rev Nutr Diet 32:165-197.